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Topic: Cancer, Pediatric oncology and onco-haematology
Category: Original article
OBJECTIVE: This study aimed to identify the clinical and prognostic characteristics of young cancer patients who were admitted to our hospital over the past two years.
PATIENTS AND METHODS: The clinical features of young cancer patients who aged 18-45 years and were diagnosed in our hospital between January 2021 and December 2022, were retrospectively analyzed. The log-rank test was employed to compare the survival rates among different groups. The prognostic factors were assessed by the multivariate Cox regression model.
RESULTS: A total of 620 cancer patients who aged 18-45 years were included. Notably, 260 (41.9%) patients were male and 360 (58.1%) were female. The median age was 38 (range, 18-45) years. The most common cancer types were thyroid cancer (182, 29.4%), non-small cell lung cancer (106, 17.1%), and soft tissue sarcoma (88, 14.2%). The median follow-up time was 18.5 (range, 3.4-29.4) months. The median overall survival was not achieved across different groups. The 2-year survival rate of all patients was 96.7%. Patients with distant metastases had worse survival than those without metastases (2-year survival rate, 84.0% vs. 99.4%, p = 0.000). Furthermore, multivariate analysis revealed that metastasis was an independent adverse prognostic factor for survival (hazard ratio 9.8, p = 0.000). A total of 17 cancer patients died, including nine patients with gastric cancer, three patients with colorectal cancer, three patients with hepatocellular carcinoma, one patient with pancreatic cancer, and one patient with glioma.
CONCLUSIONS: Metastasis was noted as an independent unfavorable prognostic factor for survival. Regular screening and timely diagnosis before metastasis are crucial to the therapy of young cancer patients.
To cite this article Wang X. K. Department of Radiology, the Fourth Medical Center, Chinese PLA General Hospital, Beijing, China , Wu Y. Department of General Practice, the Fourth Medical Center, Chinese PLA General, Beijing, China , Zhou M. H. Department 4th of Geriatric Health Care, the Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China WCRJ 2024;
11: e2737
DOI: 10.32113/wcrj_20242_2737
Submission date: 10 Dec 2023
Revised on: 02 Jan 2024
Accepted on: 05 Feb 2024
Published online: 12 Feb 2024
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