Bone–fat linkage via interleukin-11 in response to mechanical loading

Kinoshita Y, Fukumoto S (2018) X-linked hypophosphatemia and FGF23-related hypophosphatemic diseases: prospect for new treatment. Endocr Rev 39:274–291

Article  PubMed  Google Scholar 

Takashi Y, Kosako H, Sawatsubashi S, Kinoshita Y, Ito N, Tsoumpra MK, Nangaku M, Abe M, Matsuhisa M, Kato S, Matsumoto T, Fukumoto S (2019) Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation. Proc Natl Acad Sci USA 116:11418–11427

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Wei J, Karsenty G (2015) An overview of the metabolic functions of osteocalcin. Rev Endocr Metab Disord 16:93–98

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kido S, Kuriwaka-Kido R, Imamura T, Ito Y, Inoue D, Matsumoto T (2009) Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation. Bone 45:1125–1132

Article  CAS  PubMed  Google Scholar 

Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y (1991) Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Lett 283:199–202

Article  CAS  PubMed  Google Scholar 

Dong B, Hiasa M, Higa Y, Ohnishi Y, Endo I, Kondo T, Takashi Y, Tsoumpra M, Kainuma R, Sawatsubashi S, Kiyonari H, Shioi G, Sakaue H, Nakashima T, Kato S, Abe M, Fukumoto S, Matsumoto T (2022) Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis. Nat Commun 13:7194

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD, MacDougald OA (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci USA 102:3324–3329

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Levi G, Narboux-Nême N, Cohen-Solal M (2022) DLX Genes in the development and maintenance of the vertebrate skeleton: implications for human pathologies. Cells 11:3277

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baron R, Kneissel M (2013) WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med 19:179–192

Article  CAS  PubMed  Google Scholar 

Kim J, Han W, Park T, Kim EJ, Bang I, Lee HS, Jeong Y, Roh K, Kim J, Kim JS, Kang C, Seok C, Han JK, Choi HJ (2020) Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains. Nat Commun 11:5357

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Kuriwaka-Kido R, Kido S, Miyatani Y, Ito Y, Kondo T, Omatsu T, Dong B, Endo I, Miyamoto K, Matsumoto T (2013) Parathyroid hormone (1–34) counteracts the suppression of interleukin-11 expression by glucocorticoid in murine osteoblasts: a possible mechanism for stimulating osteoblast differentiation against glucocorticoid excess. Endocrinology 154:1156–1167

Article  CAS  PubMed  Google Scholar 

Rauch A, Seitz S, Baschant U, Schilling AF, Illing A et al (2010) Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab 11:517–531

Article  CAS  PubMed  Google Scholar 

Tohjima E, Inoue D, Yamamoto N, Kido S, Ito Y, Kato S, Takeuchi Y, Fukumoto S, Matsumoto T (2003) Decreased AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged mice. J Bone Miner Res 18:1461–1470

Article  CAS  PubMed  Google Scholar 

Jenkins BJ, Roberts AW, Greenhill CJ, Najdovska M, Lundgren-May T, Robb L, Grail D, Ernst M (2007) Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood 109:2380–2388

Article  CAS  PubMed  Google Scholar 

Johnstone CN, Chand A, Putoczki TL, Ernst M (2015) Emerging roles for IL-11 signaling in cancer development and progression: focus on breast cancer. Cytokine Growth Factor Rev 26:489–498

Article  CAS  PubMed  Google Scholar 

Girasole G, Passeri G, Jilka RL, Manolagas SC (1994) Interleukin-11: a new cytokine critical for osteoclast development. J Clin Invest 93:1516–1524

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taguchi Y, Yamamoto M, Yamate T, Lin SC, Mocharla H, DeTogni P, Nakayama N, Boyce BF, Abe E, Manolagas SC (1998) Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. Proc Assoc Am Physicians 110:559–574

CAS  PubMed  Google Scholar 

Kespohl B, Schumertl T, Bertrand J, Lokau J, Garbers C (2021) The cytokine interleukin-11 crucially links bone formation, remodeling and resorption. Cytokine Growth Factor Rev 60:18–27

Article  CAS  PubMed  Google Scholar 

Ng B, Widjaja AA, Viswanathan S, Dong J, Chothani SP, Lim S, Shekeran SG, Tan J, McGregor NE, Walker EC, Sims NA, Schafer S, Cook SA (2021) Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis. Sci Rep 11:14088

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Sims NA, Jenkins BJ, Nakamura A, Quinn JM, Li R, Gillespie MT, Ernst M, Robb L, Martin TJ (2005) Interleukin-11 receptor signaling is required for normal bone remodeling. J Bone Miner Res 20:1093–1102

Article  CAS  PubMed  Google Scholar 

Takeuchi Y, Watanabe S, Ishii G, Takeda S, Nakayama K, Fukumoto S, Kaneta Y, Inoue D, Matsumoto T, Harigaya K, Fujita T (2002) Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice. J Biol Chem 277:49011–49018

Article  CAS  PubMed  Google Scholar 

Watanabe Y, Ohshima H, Mizuno K, Sekiguchi C, Fukunaga M, Kohri K, Rittweger J, Felsenberg D, Matsumoto T, Nakamura T (2004) Intravenous pamidronate prevents femoral bone loss and renal stone formation during 90-day bed rest. J Bone Miner Res 19:1771–1778

Article  CAS  PubMed  Google Scholar 

Sibonga J, Matsumoto T, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Young M, Keyak J, Kohri K, Ohshima H, Spector E, LeBlanc A (2019) Resistive exercise in astronauts on prolonged spaceflights provides partial protection against spaceflight-induced bone loss. Bone 128:112037

Article  CAS  PubMed  Google Scholar 

Morey ER, Baylink DJ (1978) Inhibition of bone formation during space flight. Science 201:1138–1141

Article  ADS  CAS  PubMed  Google Scholar 

Kodama Y, Nakayama K, Fuse H, Fukumoto S, Kawahara H, Takahashi H, Kurokawa T, Sekiguchi C, Nakamura T, Matsumoto T (1997) Inhibition of bone resorption by pamidronate cannot restore normal gain in cortical bone mass and strength in tail-suspended rapidly growing rats. J Bone Miner Res 12:1058–1067

Article  CAS  PubMed  Google Scholar 

Robling AG, Turner CH (2009) Mechanical signaling for bone modeling and remodeling. Crit Rev Eukaryot Gene Expr 19:319–338

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoue D, Kido S, Matsumoto T (2004) Transcriptional induction of FosB/∆FosB gene by mechanical stress in osteoblasts. J Biol Chem 279:49795–49803

Article  CAS  PubMed  Google Scholar 

Sasaki F, Hayashi M, Mouri Y, Nakamura S, Adachi T, Nakashima T (2020) Mechanotransduction via the Piezo1-Akt pathway underlies Sost suppression in osteocytes. Biochem Biophys Res Commun 521:806–813

Article  CAS  PubMed  Google Scholar 

Liu D, Genetos DC, Shao Y, Geist DJ, Li J, Ke HZ, Turner CH, Duncan RL (2008) Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts. Bone 42:644–652

Article  CAS  PubMed  Google Scholar 

Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R (2000) Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med 6:985–990

Article  CAS  PubMed  Google Scholar 

Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T (2010) Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts. PLoS ONE 5:e13090

Article  ADS  PubMed  PubMed Central  Google Scholar 

Miyazono K, Maeda S, Imamura T (2005) BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 16:251–263

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif