Nakchbandi IA, van der Merwe SW (2009) Current understanding of osteoporosis associated with liver disease. Nat Rev Gastroenterol Hepatol 6:660–670

Article  PubMed  Google Scholar 

Santos LAA, Romeiro FG (2016) Diagnosis and management of cirrhosis-related osteoporosis. BioMed Res Int 2016:1423462

Article  PubMed  PubMed Central  Google Scholar 

Guañabens N, Parés A (2018) Osteoporosis in chronic liver disease. Liver Int 38:776–785

Article  PubMed  Google Scholar 

Jeong HM, Kim DJ (2019) Bone diseases in patients with chronic liver disease. Int J Mol Sci 20:4270

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang YJ, Kim DJ (2021) An overview of the molecular mechanisms contributing to musculoskeletal disorders in chronic liver disease: osteoporosis, sarcopenia, and osteoporotic sarcopenia. Int J Mol Sci 22:2604

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ehnert S, Aspera-Werz RH, Ruoß M, Dooley S, Hengstler JG, Nadalin S, Relja B, Badke A, Nussler AK (2019) Hepatic osteodystrophy-molecular mechanisms proposed to favor its development. Int J Mol Sci 20:2555

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saeki C, Kanai T, Ueda K, Nakano M, Oikawa T, Torisu Y, Saruta M, Tsubota A (2023) Osteosarcopenia predicts poor survival in patients with cirrhosis: a retrospective study. BMC Gastroenterol 23:196

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saeki C, Tsubota A (2021) Influencing factors and molecular pathogenesis of sarcopenia and osteosarcopenia in chronic liver disease. Life (Basel) 11:899

ADS  CAS  PubMed  Google Scholar 

Rosenberg I (1989) Summary comments: Epidemiological and methodological problems in determining nutritional status of older persons. Am J Clin Nutr 50:1231–1233

Article  Google Scholar 

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older People (2010) Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423

Article  PubMed  PubMed Central  Google Scholar 

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M, Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2, Sarcopenia: revised European consensus on definition and diagnosis (2019) Age Ageing 48:16–31

Article  PubMed  Google Scholar 

Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW et al (2014) Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15:95–101

Article  PubMed  Google Scholar 

Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY et al (2020) Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 21:300–307

Article  PubMed  Google Scholar 

Nishikawa H, Shiraki M, Hiramatsu A, Moriya K, Hino K, Nishiguchi S (2016) Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st edition): Recommendation from the working group for creation of sarcopenia assessment criteria. Hepatol Res 46:951–963

Article  PubMed  Google Scholar 

Zeng X, Shi ZW, Yu JJ, Wang LF, Luo YY, Jin SM, Zhang LY, Tan W, Shi PM, Yu H, Zhang CQ, Xie WF (2021) Sarcopenia as a prognostic predictor of liver cirrhosis: a multicentre study in China. J Cachexia Sarcopenia Muscle 12:1948–1958

Article  PubMed  PubMed Central  Google Scholar 

Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E et al (2022) Effect of sarcopenia on survival in patients with cirrhosis: a meta-analysis. J Hepatol 76:588–599

Article  PubMed  Google Scholar 

Saeki C, Oikawa T, Kanai T, Nakano M, Torisu Y, Sasaki N, Abo M, Saruta M, Tsubota A (2021) Relationship between osteoporosis, sarcopenia, vertebral fracture, and osteosarcopenia in patients with primary biliary cholangitis. Eur J Gastroenterol Hepatol 33:731–737

Article  CAS  PubMed  Google Scholar 

Saeki C, Takano K, Oikawa T, Aoki Y, Kanai T, Takakura K, Nakano M, Torisu Y, Sasaki N, Abo M, Matsuura T, Tsubota A, Saruta M (2019) Comparative assessment of sarcopenia using the JSH, AWGS, and EWGSOP2 criteria and the relationship between sarcopenia, osteoporosis, and osteosarcopenia in patients with liver cirrhosis. BMC Musculoskelet Disord 20:615

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bering T, Diniz KGD, Coelho MPP, Vieira DA, Soares MMS, Kakehasi AM, Correia MITD, Teixeira R, Queiroz DMM, Rocha GA, Silva LD (2018) Association between pre-sarcopenia, sarcopenia, and bone mineral density in patients with chronic hepatitis C. J Cachexia Sarcopenia Muscle 9:255–268

Article  PubMed  PubMed Central  Google Scholar 

Binkley N, Buehring B (2009) Beyond FRAX: it’s time to consider “sarco-osteopenia.” J Clin Densitom 12:413–416

Article  PubMed  Google Scholar 

Hirschfeld HP, Kinsella R, Duque G (2017) Osteosarcopenia: where bone, muscle, and fat collide. Osteoporos Int 28:2781–2790

Article  CAS  PubMed  Google Scholar 

Menon KV, Angulo P, Weston S, Dickson ER, Lindor KD (2001) Bone disease in primary biliary cirrhosis: independent indicators and rate of progression. J Hepatol 35:316–323

Article  CAS  PubMed  Google Scholar 

Guañabens N, Parés A, Ros I, Caballería L, Pons F, Vidal S, Monegal A, Peris P, Rodés J (2005) Severity of cholestasis and advanced histological stage but not menopausal status are the major risk factors for osteoporosis in primary biliary cirrhosis. J Hepatol 42:573–577

Article  PubMed  Google Scholar 

Guañabens N, Cerdá D, Monegal A, Pons F, Caballería L, Peris P, Parés A (2010) Low bone mass and severity of cholestasis affect fracture risk in patients with primary biliary cirrhosis. Gastroenterology 138:2348–2356

Article  PubMed  Google Scholar 

Seki A, Ikeda F, Miyatake H, Takaguchi K, Hayashi S, Osawa T, Fujioka SI, Tanaka R, Ando M, Seki H, Iwasaki Y, Yamamoto K, Okada H (2017) Risk of secondary osteoporosis due to lobular cholestasis in non-cirrhotic primary biliary cholangitis. J Gastroenterol Hepatol 32:1611–1616

Article  CAS  PubMed  Google Scholar 

Fan J, Wang Q, Sun L (2017) Association between primary biliary cholangitis and osteoporosis: meta-analysis. Clin Rheumatol 36:2565–2571

Article  PubMed  Google Scholar 

Tanaka A, Mori M, Matsumoto K, Ohira H, Tazuma S, Takikawa H (2019) Increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan. Hepatol Res 49:881–889

Article  CAS  PubMed  Google Scholar 

Manolagas SC, O’Brien CA, Almeida M (2013) The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol 9:699–712

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benetti A, Crosignani A, Varenna M, Giussani CS, Allocca M, Zuin M, Podda M, Battezzati PM (2008) Primary biliary cirrhosis is not an additional risk factor for bone loss in women receiving regular calcium and vitamin D supplementation: a controlled longitudinal study. J Clin Gastroenterol 42:306–311

Article  PubMed  Google Scholar 

Saeki C, Oikawa T, Ueda K, Nakano M, Torisu Y, Saruta M, Tsubota A (2022) Serum insulin-like growth factor 1 levels, fracture risk assessment tool scores and bone disorders in patients with primary biliary cholangitis. Diagnostics (Basel) 12:1957

Article  CAS  PubMed  Google Scholar 

Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ (2018) The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology 67:328–357

Article  PubMed  Google Scholar 

Kazankov K, Jørgensen SMD, Thomsen KL, Møller HJ, Vilstrup H, George J, Schuppan D, Grønbæk H (2019) The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Nat Rev Gastroenterol Hepatol 16:145–159

Article  CAS  PubMed  Google Scholar 

Vachliotis ID, Anastasilakis AD, Goulas A, Goulis DG, Polyzos SA (2022) Nonalcoholic fatty liver disease and osteoporosis: a potential association with therapeutic implications. Diabetes Obes Metab 24:1702–1720

Article  CAS  PubMed  Google Scholar 

Filip R, Radzki RP, Bieńko M (2018) Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis. Clin Interv Aging 13:1879–1891

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim G, Kim KJ, Rhee Y, Lim SK (2017) Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease. PLoS ONE 12:e0182202

Article  PubMed  PubMed Central  Google Scholar 

Umehara T (2018) Nonalcoholic fatty liver disease with elevated alanine aminotransferase levels is negatively associated with bone mineral density: cross-sectional study in U.S. adults. PLoS ONE 13:e0197900

Article