Dong, X., Han, S., Zylka, M. J., Simon, M. I. & Anderson, D. J. (2001). A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell, 106, 619–632.

Article  CAS  PubMed  Google Scholar 

Lembo, P. M., Grazzini, E., Groblewski, T., O’donnell, D., Roy, M. O., Zhang, J., Hoffert, C., Cao, J., Schmidt, R., Pelletier, M., Labarre, M., Gosselin, M., Fortin, Y., Banville, D., Shen, S. H., Ström, P., Payza, K., Dray, A., Walker, P. & Ahmad, S. (2002). Proenkephalin a gene products activate a new family of sensory neuron-specific GPCRs. Nature Neuroscience, 5, 201–209.

Article  CAS  PubMed  Google Scholar 

Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X. & Bautista, D. M. (2011). TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nature Neuroscience, 14, 595–602.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Njoo C., Heinl C. & Kuner R. (2014). In vivo SiRNA transfection and gene knockdown in spinal cord via rapid noninvasive lumbar intrathecal injections in mice. Jounal of Visualized Experimentals, 85, 51229.

Sun, Y. E., Lu, C. E., Lei, Y., Liu, Y., Ma, Z. & Gu, X. (2015). Mas-related G-protein-coupled receptor c agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. International Journal of Clinical and Experimental Medicine, 8, 20178–20187.

CAS  PubMed  PubMed Central  Google Scholar 

Prchalová, E., Hin, N., Thomas, A. G., Veeravalli, V., Ng, J., Alt, J., Rais, R., Rojas, C., Li, Z., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., Kopajtic, T., Chatrath, S., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T. (2019). Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. Journal of Medical Chemistry, 62, 8631–8641.

Article  Google Scholar 

Hin, N., Alt, J., Zimmermann, S. C., Delahanty, G., Ferraris, D. V., Rojas, C., Li, F., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T. (2014). Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorganic and Medical Chemistry, 22, 5831–5837.

Article  CAS  Google Scholar 

Berhane, I., Hin, N., Thomas, A. G., Huang, Q., Zhang, C., Veeravalli, V., Wu, Y., Ng, J., Alt, J., Rojas, C., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., He, S. Q., Peng, Q., Guan, Y., Dong, X., Raja, S. N., Slusher, B. S., Rais, R. & Tsukamoto, T. (2022). Thieno[2,3-d]pyrimidine-based positive allosteric modulators of human mas-related G Protein-Coupled Receptor X1 (MRGPRX1). Journal of Medical Chemistry, 65, 3218–3228.

Article  CAS  Google Scholar 

Jean-Alphonse, F. & Hanyaloglu, A. C. (2011). Regulation of GPCR signal networks via membrane trafficking. Molecular and Cellular Endocrinology, 331, 205–214.

Article  CAS  PubMed  Google Scholar 

Huang, Q., Ford, N. C., Gao, X., Chen, Z., Guo, R., Raja, S. N., Guan, Y. & He, S. (2021). Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats. Pain, 162, 1082–1094.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Swatek, K. N. & Komander, D. (2016). Ubiquitin modifications. Cell Research, 26, 399–422.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao, B., Tsai, Y. C., Jin, B., Wang, B., Wang, Y., Zhou, H., Carpenter, T., Weissman, A. M. & Yin, J. (2020). Protein engineering in the ubiquitin system: tools for discovery and beyond. Pharmacological Reviews, 72, 380–413.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clague, M. J., Urbé, S. & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function. Nature Reviews Molecular Cell Biology, 20, 338–352.

Article  CAS  PubMed  Google Scholar 

Garcia-Caballero, A., Gadotti, V. M., Ali, M. Y., Bladen, C., Gambeta, E., Van Humbeck, J. F., Maccallum, J. L. & Zamponi, G. W. (2022). A synthetically accessible small-molecule inhibitor of USP5-Cav3.2 calcium channel interactions with analgesic properties. ACS Chemical Neuroscience, 13, 524–536.

Article  CAS  PubMed  Google Scholar 

Bang, Y., Kwon, Y., Kim, M., Moon, S. H., Jung, K. & Choi, H. J. (2023). Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model. Acta Pharmacologica Sinica, 44, 752–765.

Article  CAS  PubMed  Google Scholar 

Huang, S., Zheng, X., Zhang, X., Jin, Z., Liu, S., Fu, L. & Niu, Y. (2022). Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle. Applied Physiology, Nutrition, and metabolism, 47, 1062–1074.

Article  CAS  PubMed  Google Scholar 

Marei, H., Tsai, W. K., Kee, Y. S., Ruiz, K., He, J., Cox, C., Sun, T., Penikalapati, S., Dwivedi, P., Choi, M., Kan, D., Saenz-Lopez, P., Dorighi, K., Zhang, P., Kschonsak, Y. T., Kljavin, N., Amin, D., Kim, I., Mancini, A. G., Nguyen, T., Wang, C., Janezic, E., Doan, A., Mai, E., Xi, H., Gu, C., Heinlein, M., Biehs, B., Wu, J., Lehoux, I., Harris, S., Comps-Agrar, L., Seshasayee, D., De Sauvage, F. J., Grimmer, M., Li, J., Agard, N. J. & De Sousa, E. M. F. (2022). Antibody targeting of E3 ubiquitin ligases for receptor degradation. Nature, 610, 182–189.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee, K., Kim, M. Y., Ahn, H., Kim, H. S., Shin, H. I. & Jeong, D. (2017). Blocking of the Ubiquitin-Proteasome system prevents inflammation-induced bone loss by accelerating M-CSF receptor c-Fms degradation in osteoclast differentiation. International Journal of Molecular Sciences, 18, 2054

Article  PubMed  PubMed Central  Google Scholar 

Park, J., Cho, J. & Song, E. J. (2020). Ubiquitin-proteasome system (UPS) as a target for anticancer treatment. Archives of Pharmacal Research, 43, 1144–1161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manasanch, E. E. & Orlowski, R. Z. (2017). Proteasome inhibitors in cancer therapy. Nature Reviews Clinical Oncology, 14, 417–433.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akutsu, M., Dikic, I. & Bremm, A. (2016). Ubiquitin chain diversity at a glance. Journal of Cell Science, 129, 875–880.

CAS  PubMed  Google Scholar 

Ohtake, F., Saeki, Y., Ishido, S., Kanno, J. & Tanaka, K. (2016). The K48-K63 branched Ubiquitin chain regulates NF-kappaB signaling. Molecular Cell, 64, 251–266.

Article  CAS  PubMed  Google Scholar 

Vijayaraj, S. L., Feltham, R., Rashidi, M., Frank, D., Liu, Z., Simpson, D. S., Ebert, G., Vince, A., Herold, M. J., Kueh, A., Pearson, J. S., Dagley, L. F., Murphy, J. M., Webb, A. I., Lawlor, K. E. & Vince, J. E. (2021). The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. Nature Communications, 12, 2713.

Article  PubMed  PubMed Central  Google Scholar 

He, X., Zhu, Y., Zhang, Y., Geng, Y., Gong, J., Geng, J., Zhang, P., Zhang, X., Liu, N., Peng, Y., Wang, C., Wang, Y., Liu, X., Wan, L., Gong, F., Wei, C. & Zhong, H. (2019). RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation. The EMBO Journal, 38, e100978.

Article  PubMed  PubMed Central  Google Scholar