Dong, X., Han, S., Zylka, M. J., Simon, M. I. & Anderson, D. J. (2001). A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell, 106, 619–632.
Article CAS PubMed Google Scholar
Lembo, P. M., Grazzini, E., Groblewski, T., O’donnell, D., Roy, M. O., Zhang, J., Hoffert, C., Cao, J., Schmidt, R., Pelletier, M., Labarre, M., Gosselin, M., Fortin, Y., Banville, D., Shen, S. H., Ström, P., Payza, K., Dray, A., Walker, P. & Ahmad, S. (2002). Proenkephalin a gene products activate a new family of sensory neuron-specific GPCRs. Nature Neuroscience, 5, 201–209.
Article CAS PubMed Google Scholar
Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X. & Bautista, D. M. (2011). TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nature Neuroscience, 14, 595–602.
Article CAS PubMed PubMed Central Google Scholar
Njoo C., Heinl C. & Kuner R. (2014). In vivo SiRNA transfection and gene knockdown in spinal cord via rapid noninvasive lumbar intrathecal injections in mice. Jounal of Visualized Experimentals, 85, 51229.
Sun, Y. E., Lu, C. E., Lei, Y., Liu, Y., Ma, Z. & Gu, X. (2015). Mas-related G-protein-coupled receptor c agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. International Journal of Clinical and Experimental Medicine, 8, 20178–20187.
CAS PubMed PubMed Central Google Scholar
Prchalová, E., Hin, N., Thomas, A. G., Veeravalli, V., Ng, J., Alt, J., Rais, R., Rojas, C., Li, Z., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., Kopajtic, T., Chatrath, S., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T. (2019). Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. Journal of Medical Chemistry, 62, 8631–8641.
Hin, N., Alt, J., Zimmermann, S. C., Delahanty, G., Ferraris, D. V., Rojas, C., Li, F., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T. (2014). Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Bioorganic and Medical Chemistry, 22, 5831–5837.
Berhane, I., Hin, N., Thomas, A. G., Huang, Q., Zhang, C., Veeravalli, V., Wu, Y., Ng, J., Alt, J., Rojas, C., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., He, S. Q., Peng, Q., Guan, Y., Dong, X., Raja, S. N., Slusher, B. S., Rais, R. & Tsukamoto, T. (2022). Thieno[2,3-d]pyrimidine-based positive allosteric modulators of human mas-related G Protein-Coupled Receptor X1 (MRGPRX1). Journal of Medical Chemistry, 65, 3218–3228.
Jean-Alphonse, F. & Hanyaloglu, A. C. (2011). Regulation of GPCR signal networks via membrane trafficking. Molecular and Cellular Endocrinology, 331, 205–214.
Article CAS PubMed Google Scholar
Huang, Q., Ford, N. C., Gao, X., Chen, Z., Guo, R., Raja, S. N., Guan, Y. & He, S. (2021). Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats. Pain, 162, 1082–1094.
Article CAS PubMed PubMed Central Google Scholar
Swatek, K. N. & Komander, D. (2016). Ubiquitin modifications. Cell Research, 26, 399–422.
Article CAS PubMed PubMed Central Google Scholar
Zhao, B., Tsai, Y. C., Jin, B., Wang, B., Wang, Y., Zhou, H., Carpenter, T., Weissman, A. M. & Yin, J. (2020). Protein engineering in the ubiquitin system: tools for discovery and beyond. Pharmacological Reviews, 72, 380–413.
Article CAS PubMed PubMed Central Google Scholar
Clague, M. J., Urbé, S. & Komander, D. (2019). Breaking the chains: deubiquitylating enzyme specificity begets function. Nature Reviews Molecular Cell Biology, 20, 338–352.
Article CAS PubMed Google Scholar
Garcia-Caballero, A., Gadotti, V. M., Ali, M. Y., Bladen, C., Gambeta, E., Van Humbeck, J. F., Maccallum, J. L. & Zamponi, G. W. (2022). A synthetically accessible small-molecule inhibitor of USP5-Cav3.2 calcium channel interactions with analgesic properties. ACS Chemical Neuroscience, 13, 524–536.
Article CAS PubMed Google Scholar
Bang, Y., Kwon, Y., Kim, M., Moon, S. H., Jung, K. & Choi, H. J. (2023). Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model. Acta Pharmacologica Sinica, 44, 752–765.
Article CAS PubMed Google Scholar
Huang, S., Zheng, X., Zhang, X., Jin, Z., Liu, S., Fu, L. & Niu, Y. (2022). Exercise improves high-fat diet-induced metabolic disorder by promoting HDAC5 degradation through the ubiquitin-proteasome system in skeletal muscle. Applied Physiology, Nutrition, and metabolism, 47, 1062–1074.
Article CAS PubMed Google Scholar
Marei, H., Tsai, W. K., Kee, Y. S., Ruiz, K., He, J., Cox, C., Sun, T., Penikalapati, S., Dwivedi, P., Choi, M., Kan, D., Saenz-Lopez, P., Dorighi, K., Zhang, P., Kschonsak, Y. T., Kljavin, N., Amin, D., Kim, I., Mancini, A. G., Nguyen, T., Wang, C., Janezic, E., Doan, A., Mai, E., Xi, H., Gu, C., Heinlein, M., Biehs, B., Wu, J., Lehoux, I., Harris, S., Comps-Agrar, L., Seshasayee, D., De Sauvage, F. J., Grimmer, M., Li, J., Agard, N. J. & De Sousa, E. M. F. (2022). Antibody targeting of E3 ubiquitin ligases for receptor degradation. Nature, 610, 182–189.
Article CAS PubMed PubMed Central Google Scholar
Lee, K., Kim, M. Y., Ahn, H., Kim, H. S., Shin, H. I. & Jeong, D. (2017). Blocking of the Ubiquitin-Proteasome system prevents inflammation-induced bone loss by accelerating M-CSF receptor c-Fms degradation in osteoclast differentiation. International Journal of Molecular Sciences, 18, 2054
Article PubMed PubMed Central Google Scholar
Park, J., Cho, J. & Song, E. J. (2020). Ubiquitin-proteasome system (UPS) as a target for anticancer treatment. Archives of Pharmacal Research, 43, 1144–1161.
Article CAS PubMed PubMed Central Google Scholar
Manasanch, E. E. & Orlowski, R. Z. (2017). Proteasome inhibitors in cancer therapy. Nature Reviews Clinical Oncology, 14, 417–433.
Article CAS PubMed PubMed Central Google Scholar
Akutsu, M., Dikic, I. & Bremm, A. (2016). Ubiquitin chain diversity at a glance. Journal of Cell Science, 129, 875–880.
Ohtake, F., Saeki, Y., Ishido, S., Kanno, J. & Tanaka, K. (2016). The K48-K63 branched Ubiquitin chain regulates NF-kappaB signaling. Molecular Cell, 64, 251–266.
Article CAS PubMed Google Scholar
Vijayaraj, S. L., Feltham, R., Rashidi, M., Frank, D., Liu, Z., Simpson, D. S., Ebert, G., Vince, A., Herold, M. J., Kueh, A., Pearson, J. S., Dagley, L. F., Murphy, J. M., Webb, A. I., Lawlor, K. E. & Vince, J. E. (2021). The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. Nature Communications, 12, 2713.
Article PubMed PubMed Central Google Scholar
He, X., Zhu, Y., Zhang, Y., Geng, Y., Gong, J., Geng, J., Zhang, P., Zhang, X., Liu, N., Peng, Y., Wang, C., Wang, Y., Liu, X., Wan, L., Gong, F., Wei, C. & Zhong, H. (2019). RNF34 functions in immunity and selective mitophagy by targeting MAVS for autophagic degradation. The EMBO Journal, 38, e100978.
留言 (0)