World Health Organization. Deafness and hearing loss. who.int, https: //www.who.int/news-room/fact-sheets/detail/deafness-and-hearing-loss (accessed 1 March 2023).

National Institute on Deafness and Other Communication Disorders, National Institutes of Health. Quick statistics about hearing. nidcd.nih.gov, https: //www.nidcd.nih.gov/health/statistics/quick-statistics-hearing (accessed 1 March 2023).

Mick, P. T. et al. The prevalence of hearing, vision, and dual sensory loss in older Canadians: an analysis of data from the Canadian Longitudinal Study on Aging. Can. J. Aging 40, 1–22 (2021).

Article  PubMed  Google Scholar 

World Health Organization. Integrated people-centred ear and hearing care: policy brief. apps.who.int, https://apps.who.int/iris/handle/10665/339957 (accessed 1 March 2023).

Anderson, D. L. & Noble, W. Couples’ attributions about behaviours modulated by hearing impairment: links with relationship satisfaction. Int. J. Audiol. 44, 197–205 (2005).

Article  PubMed  Google Scholar 

Hétu, R., Jones, L. & Getty, L. The impact of acquired hearing impairment on intimate relationships: implications for rehabilitation. Audiology 32, 363–381 (1993).

Article  PubMed  Google Scholar 

National Research Council (US) Committee on Disability Determination for Individuals with Hearing Impairments. Hearing Loss: Determining Eligibility for Social Security Benefits. (National Academies Press (US), 2004).

Tordrup, D. et al. Global return on investment and cost-effectiveness of WHO’s HEAR interventions for hearing loss: a modelling study. Lancet Glob. Health 10, e52–e62 (2022).

Article  PubMed  Google Scholar 

Monzani, D., Galeazzi, G. M., Genovese, E., Marrara, A. & Martini, A. Psychological profile and social behaviour of working adults with mild or moderate hearing loss. Acta Otorhinolaryngol. Ital. 28, 61–66 (2008).

PubMed  PubMed Central  Google Scholar 

Lin, F. R. & Albert, M. Hearing loss and dementia — who is listening? Aging Ment. Health 18, 671–673 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Dalton, D. S. et al. The impact of hearing loss on quality of life in older adults. Gerontologist 43, 661–668 (2003).

Article  PubMed  Google Scholar 

Hixon, B., Chan, S., Adkins, M., Shinn, J. B. & Bush, M. L. Timing and impact of hearing healthcare in adult cochlear implant recipients: a rural-urban comparison. Otol. Neurotol. 37, 1320–1324 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Nieman, C. L., Marrone, N., Szanton, S. L., Thorpe, R. J. Jr & Lin, F. R. Racial/ethnic and socioeconomic disparities in hearing health care among older Americans. J. Aging Health 28, 68–94 (2016).

Article  PubMed  Google Scholar 

Schuh, M. R. & Bush, M. L. Evaluating equity through the social determinants of hearing health. Ear Hear. 43, 15s–22s (2022).

Article  PubMed  Google Scholar 

World Health Organization. World Report on Hearing. apps.who.int, https: //apps.who.int/iris/handle/10665/339913 (accessed 1 March 2023).

Agrawal, Y., Platz, E. A. & Niparko, J. K. Prevalence of hearing loss and differences by demographic characteristics among US adults: data from the National Health and Nutrition Examination Survey, 1999–2004. Arch. Intern. Med. 168, 1522–1530 (2008).

Article  PubMed  Google Scholar 

Ramage-Morin, P. L., Banks, R., Pineault, D. & Atrach, M. Unperceived hearing loss among Canadians aged 40 to 79. Health Rep. 30, 11–20 (2019).

PubMed  Google Scholar 

Baguant, A., Cole, A., Vilotitch, A., Quatre, R. & Schmerber, S. Difference in cochlear length between male and female patients. Cochlear Implant. 23, 326–331 (2022).

Article  Google Scholar 

Shuster, B. Z., Depireux, D. A., Mong, J. A. & Hertzano, R. Sex differences in hearing: probing the role of estrogen signaling. J. Acoust. Soc. Am. 145, 3656 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Tonelli, M. et al. Associations between hearing loss and clinical outcomes: population-based cohort study. EClinicalMedicine 61, 102068 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Newsted, D. et al. Approach to hearing loss. Can. Fam. Physician 66, 803–809 (2020).

PubMed  PubMed Central  Google Scholar 

Snoeckx, R. L. et al. GJB2 mutations and degree of hearing loss: a multicenter study. Am. J. Hum. Genet. 77, 945–957 (2005).

Article  PubMed  PubMed Central  Google Scholar 

Anthwal, N. & Thompson, H. The development of the mammalian outer and middle ear. J. Anat. 228, 217–232 (2016).

Article  PubMed  Google Scholar 

Luers, J. C. & Huttenbrink, K. B. Surgical anatomy and pathology of the middle ear. J. Anat. 228, 338–353 (2016).

Article  PubMed  Google Scholar 

Hartwein, J. H. & Rauchfuss, A. The development of the ossicular ligaments in the human middle ear. Arch. Otorhinolaryngol. 244, 23–25 (1987).

Article  PubMed  Google Scholar 

McCarroll, M. N. et al. Graded levels of Pax2a and Pax8 regulate cell differentiation during sensory placode formation. Development 139, 2740–2750 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Sai, X. & Ladher, R. K. FGF signaling regulates cytoskeletal remodeling during epithelial morphogenesis. Curr. Biol. 18, 976–981 (2008).

Article  PubMed  Google Scholar 

Alvarez, Y. et al. Requirements for FGF3 and FGF10 during inner ear formation. Development 130, 6329–6338 (2003).

Article  PubMed  Google Scholar 

Pauley, S. et al. Expression and function of FGF10 in mammalian inner ear development. Dev. Dyn. 227, 203–215 (2003).

Article  PubMed  PubMed Central  Google Scholar 

Riley, B. B. & Phillips, B. T. Ringing in the new ear: resolution of cell interactions in otic development. Dev. Biol. 261, 289–312 (2003).

Article  PubMed  Google Scholar 

Brigande, J. V., Kiernan, A. E., Gao, X., Iten, L. E. & Fekete, D. M. Molecular genetics of pattern formation in the inner ear: do compartment boundaries play a role? Proc. Natl Acad. Sci. USA 97, 11700–11706 (2000).

Article  PubMed  PubMed Central  Google Scholar 

Chatterjee, S., Kraus, P. & Lufkin, T. A symphony of inner ear developmental control genes. BMC Genet. 11, 68 (2010).

Article  PubMed  PubMed Central  Google Scholar 

Bok, J. et al. Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear. Proc. Natl Acad. Sci. USA 108, 161–166 (2011).

Article  PubMed  Google Scholar 

Chang, W., Nunes, F. D., De Jesus-Escobar, J. M., Harland, R. & Wu, D. K. Ectopic noggin blocks sensory and nonsensory organ morphogenesis in the chicken inner ear. Dev. Biol. 216, 369–381 (1999).

Article  PubMed  Google Scholar 

Riccomagno, M. M., Takada, S. & Epstein, D. J. Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes. Dev. 19, 1612–1623 (2005).

Article  PubMed  PubMed Central  Google Scholar 

Zheng, W. et al. The role of Six1 in mammalian auditory system development. Development 130, 3989–4000 (2003).

Article  PubMed  Google Scholar 

Ozaki, H. et al. Six1 controls patterning of the mouse otic vesicle. Development 131, 551–562 (2004).

Article  PubMed  Google Scholar 

Khan, S. & Chang, R. Anatomy of the vestibular system: a review. NeuroRehabilitation 32, 437–443 (2013).

Article  PubMed  Google Scholar 

Driver, E. C. & Kelley, M. W. Development of the cochlea. Development 147, dev162263 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Moser, T. & Starr, A. Auditory neuropathy — neural and synaptic mechanisms. Nat. Rev. Neurol. 12, 135–149 (2016).

Article  PubMed  Google Scholar 

Raphael, R. M. Outer hair cell electromechanics as a problem in soft matter physics: prestin, the membrane and the cytoskeleton. Hear. Res. 423, 108426 (2022).

Article  PubMed  Google Scholar 

Zhou, W., Jabeen, T., Sabha, S., Becker, J. & Nam, J. H. Deiters cells act as mechanical equalizers for outer hair cells. J. Neurosci. 42, 8361–8372 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Maier, E. C. & Whitfield, T. T. RA and FGF signalling are required in the zebrafish otic vesicle to pattern and maintain ventral otic identities. PLoS Genet. 10, e1004858 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Ahmed, M. et al. Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev. Cell 22, 377–390 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Kamaid, A., Neves, J. & Giraldez, F. Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1. J. Neurosci. 30, 11426–11434 (2010).

Article  PubMed  PubMed Central