Int J Sports Med
DOI: 10.1055/a-2234-0159
Genetics & Molecular Biology
Tao Mei
1
China Institute of Sport and Health Science, Beijing Sport University,
Beijing, China
,
Yanchun Li
1
China Institute of Sport and Health Science, Beijing Sport University,
Beijing, China
,
Xiaoxia Li
2
Department of Teaching Affairs, Shandong Sport University, Jinan,
China
,
Xiaolin Yang
1
China Institute of Sport and Health Science, Beijing Sport University,
Beijing, China
,
Liang Li
3
Academy of Sports, Sultan Idris Education University, Tanjung Malim,
Malaysia
,
Xu Yan
4
Institute for Health and Sport, Victoria University, Melbourne,
Australia
,
Zi-hong He
5
Exercise Biology Research Center, China Institute of Sport Science,
Beijing, China
› Author Affiliations
Funding Information
Fundamental Research Funds for the Central Universities — http://
dx.doi.org/10.13039/501100012226; 2016SYS002
National Key R&D Program of China — 2018YFC2000602
› Further Information
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Abstract
This study develops a comprehensive genotype-phenotype model for predicting the
effects of resistance training on leg press performance. A cohort of physically
inactive adults (N=193) underwent 12 weeks of resistance training, and
measurements of maximum isokinetic leg press peak force, muscle mass, and
thickness were taken before and after the intervention. Whole-genome genotyping
was performed, and genome-wide association analysis identified 85 novel SNPs
significantly associated with changes in leg press strength after training. A
prediction model was constructed using stepwise linear regression, incorporating
seven lead SNPs that explained 40.4% of the training effect variance.
The polygenic score showed a significant positive correlation with changes in
leg press strength. By integrating genomic markers and phenotypic indicators,
the comprehensive prediction model explained 75.4% of the variance in
the training effect. Additionally, five SNPs were found to potentially impact
muscle contraction, metabolism, growth, and development through their
association with REACTOME pathways. Individual responses to resistance training
varied, with changes in leg press strength ranging from −55.83%
to 151.20%. The study highlights the importance of genetic factors in
predicting training outcomes and provides insights into the potential biological
functions underlying resistance training effects. The comprehensive model offers
valuable guidance for personalized fitness programs based on individual genetic
profiles and phenotypic characteristics.
Key words
genome-wide association study -
strength training effects -
isokinetic strength -
personalized exercise -
predictive model
Publication History
Received: 01 July 2023
Accepted: 20 December 2023
Accepted Manuscript online:
20 December 2023
Article published online:
29 January 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart,
Germany
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