Therapeutic Management of Malignant Wounds: An Update

Stolnicu S, Barsan I, Bauer O, Moldovan C, Chiriac A, Coros MF, et al. Areolar metastases of skin malignant melanoma - report of a unique case. Breast J. 2017;23:470–1.

Article  PubMed  Google Scholar 

Mihai MM, Ion A, Giurcăneanu C, Nițipir C, Popa A-M, Chifiriuc M-C, et al. The impact of long-term antibiotic therapy of cutaneous adverse reactions to EGFR inhibitors in colorectal cancer patients. J Clin Med. 2021;10:3219.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Probst S, Arber A, Faithfull S. Malignant fungating wounds – the meaning of living in an unbounded body. European Journal of Oncology Nursing. 2013;17:38–45.

Article  PubMed  Google Scholar 

Beers EH. Palliative wound care. Surgical Clinics of North America. 2019;99:899–919.

Article  PubMed  Google Scholar 

Beh SY, Leow LC. Fungating breast cancer and other malignant wounds: epidemiology, assessment and management. Expert Rev Qual Life Cancer Care. 2016;1:137–44.

Article  Google Scholar 

Starace M, Carpanese MA, Pampaloni F, Dika E, Pileri A, Rubino D, et al. Management of malignant cutaneous wounds in oncologic patients. Supportive Care in Cancer. 2022;30:7615–23. This reference is of importance for clinicians, providing retrospective information from a series of patients with such challenging wounds.

Article  PubMed  PubMed Central  Google Scholar 

Isoherranen K, O’Brien JJ, Barker J, Dissemond J, Hafner J, Jemec GBE, et al. Atypical wounds. Best clinical practice and challenges. J Wound Care. 2019;28:S1-92.

Article  PubMed  Google Scholar 

Fauziyah H, Gayatri D. Pain, stress, and sleep quality in chronic wound patients. Enferm Clin. 2018;28:176–9.

Article  Google Scholar 

Vardhan M, Flaminio Z, Sapru S, Tilley CP, Fu MR, Comfort C, et al. The microbiome, malignant fungating wounds, and palliative care. Front Cell Infect Microbiol. 2019;9:379.

Article  Google Scholar 

Maida V. Medical cannabis in the palliation of malignant wounds—a case report. J Pain Symptom Manage. 2017;53:e4-6.

Article  PubMed  Google Scholar 

Luo B, Xiao Y, Jiang M, Wang L, Ge Y, Zheng M. Successful management of exudate and odor using a pouch system in a patient with malignant facial wound: a case report. Asia Pac J Oncol Nurs. 2022;9:236–41. This reference is of outstanding importance because it describes an interesting and inexpensive method of managing malignant wounds. The case report provides details on the successful use of an ostomy pouch on a facial fungating wound caused by maxillary gingival carcinoma.

Article  PubMed  PubMed Central  Google Scholar 

O’Brien C. Malignant wounds. Can Fam Physician. 2012;58:272–4.

PubMed  PubMed Central  Google Scholar 

Yukuyama MN, Guimaraes LMF, Segovia RS, Lameu C, de Araujo GLB, Löbenberg R, et al. Malignant wound – the influence of oil components in flubendazole-loaded nanoemulsions in A549 lung cancer xenograft-bearing mice. J Drug Deliv Sci Technol. 2022;78:103963. This reference is of outstanding importance because it reports on the potential use of flubendazole-loaded nanoemulsions as an advanced strategy for malignant wound prevention and treatment, given the synergistic action observed in vivo between the carried drug and the oil derived from linoleic acid.

Article  CAS  Google Scholar 

Tamai N, Mugita Y, Ikeda M, Sanada H. The relationship between malignant wound status and pain in breast cancer patients. Eur J Oncol Nurs. 2016;24:8–12.

Article  PubMed  Google Scholar 

Tilley C, Lipson J, Ramos M. Palliative wound care for malignant fungating wounds. Nurs Clin North Am. 2016;51:513–31.

Article  PubMed  Google Scholar 

Cornish L. Holistic management of malignant wounds in palliative patients. Br J Community Nurs. 2019;24:S19-23.

Article  PubMed  Google Scholar 

Qiu JM, DelVecchio Good M-J. Making the best of multidisciplinary care for patients with malignant fungating wounds: a qualitative study of clinicians’ narratives. Palliat Med. 2021;35:179–87.

Article  PubMed  Google Scholar 

Bolton L. Evidence corner: evidence-based care for malignant wounds. Wounds. 2016;28:2014–6.

Google Scholar 

Tandler S, Stephen-Haynes J. Fungating wounds: management and treatment options. Brit J Nurs. 2017;26:S6-14.

Article  Google Scholar 

Tilley CP, Fu MR, Qiu JM, Comfort C, Crocilla BL, Li Z, et al. The microbiome and metabolome of malignant fungating wounds. J Wound Ostomy Continence Nurs. 2021;48:124–35. This reference is of importance because it systematically reviews studies published over a 25-year period, emphasizing the role of microbiota in developing or amplifying the severity of malignant wound symptoms.

Article  PubMed  Google Scholar 

Hossain MF. Wound care: a material solution. encyclopedia of renewable and sustainable materials. Elsevier; 2020. p. 915–29

Gethin G, Grocott P, Probst S, Clarke E. Current practice in the management of wound odour: an international survey. Int J Nurs Stud. 2014;51:865–74.

Article  PubMed  Google Scholar 

Gethin G, Vellinga A, McIntosh C, Sezgin D, Probst S, Murphy L, et al. Systematic review of topical interventions for the management of odour in patients with chronic or malignant fungating wounds. J Tissue Viability. 2023;32:151–7. This reference is of importance because it provides an updated overview of topical interventions in the management of odour in patients with malignant wounds, especially highlighting the roles of metronidazole and silver.

Article  CAS  PubMed  Google Scholar 

Fromantin I, Seyer D, Watson S, Rollot F, Elard J, Escande MC, et al. Bacterial floras and biofilms of malignant wounds associated with breast cancers. J Clin Microbiol. 2013;51:3368–73.

Article  PubMed  PubMed Central  Google Scholar 

Johnson T, Gómez B, McIntyre M, Dubick M, Christy R, Nicholson S, et al. The cutaneous microbiome and wounds: new molecular targets to promote wound healing. Int J Mol Sci. 2018;19:2699.

Article  PubMed  PubMed Central  Google Scholar 

Powers JG, Higham C, Broussard K, Phillips TJ. Wound healing and treating wounds. J Am Acad Dermatol. 2016;74:607–25.

Article  PubMed  Google Scholar 

Tsichlakidou A, Govina O, Vasilopoulos G, Kavga A, Vastardi M, Kalemikerakis I. Intervention for symptom management in patients with malignant fungating wounds - a systematic review. J BUON. 2019;24:1301–8.

PubMed  Google Scholar 

Ramasubbu DA, Smith V, Hayden F, Cronin P. Systemic antibiotics for treating malignant wounds. Cochrane Datab System Rev. 2017;8:CD011609.

Google Scholar 

Adderley UJ, Holt IG. Topical agents and dressings for fungating wounds. Cochrane Datab System Rev. 2014;2014:CD003948.

Google Scholar 

Villela-Castro DL, de Santos VLCG, Woo K. Polyhexanide versus metronidazole for odor management in malignant (fungating) wounds. J Wound Ostom Contin Nurs. 2018;45:413–8.

Article  Google Scholar 

Firmino F, Villela-Castro DL, Santos J dos, Conceição de Gouveia Santos VL. Topical management of bleeding from malignant wounds caused by breast cancer: a systematic review. J Pain Symptom Manage. 2021;61:1278–86.

da Costa Ferreira SA, Serna González CV, Thum M, da Costa Faresin AA, Woo K, de Gouveia Santos VLC. Topical therapy for pain management in malignant fungating wounds: a scoping review. J Clin Nurs. 2023;32:3015–29.

Article  PubMed  Google Scholar 

Ghaly P, Kim YD, Iliopoulos J, Ahmad M. The management of malignant lower limb ulcers: clinical considerations. Br J Nurs. 2020;29:S34-40.

Article  PubMed  Google Scholar 

Hoshi M, Oebisu N, Iwai T, Ieguchi M, Nakamura H. Clinical course of soft tissue sarcomas presenting as malignant wounds. J Orthop Sci. 2019;24:1088–93.

Article  PubMed  Google Scholar 

Woo KY, Krasner DL, Kennedy B, Wardle D, Moir O. Palliative wound care management strategies for palliative patients and their circles of care. Adv Skin Wound Care. 2015;28:130–40.

Article  PubMed  Google Scholar 

Nicodème M, Dureau S, Chéron M, Kriegel I, Trenchand M, Bauër P, et al. Frequency and management of hemorrhagic malignant wounds: a retrospective, single-center, observational study. J Pain Symptom Manage. 2021;62:134–40. This reference is of importance because, after gathering observations from 90 patients, it concluded that malignant wounds with minor or hemorrhagic bleeding tend to be associated with a poor prognosis, suggesting the necessity of using hemostatic dressings in affected patients.

Article  PubMed  Google Scholar 

Akhmetova A, Saliev T, Allan IU, Illsley MJ, Nurgozhin T, Mikhalovsky S. A comprehensive review of topical odor-controlling treatment options for chronic wounds. J Wound Ostom Contin Nurs. 2016;43:598–609.

Article  Google Scholar 

Vowden K, Vowden P. Wound dressings: principles and practice. Surgery (Oxford). 2017;35:489–94.

Article  Google Scholar 

Wang Y, Yang Y, Shi Y, Song H, Yu C. Antibiotic-free antibacterial strategies enabled by nanomaterials: progress and perspectives. Adv Mater. 2020;32:1904106.

Article  CAS  Google Scholar 

Winardi A, Irwan AM. Topical treatment for controlling malignant wound odour. EWMA Journal. 2019;20.

Gherasim O, Puiu RA, Bîrcă AC, Burdușel A-C, Grumezescu AM. An updated review on silver nanoparticles in biomedicine. Nanomaterials. 2020;10:2318.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saikaly SK, Khachemoune A. Honey and wound healing: an update. Am J Clin Dermatol. 2017;18:237–51.

Article  PubMed  Google Scholar 

Yilmaz AC, Aygin D. Honey dressing in wound treatment: a systematic review. Complement Ther Med. 2020;51:102388.

Article  PubMed  Google Scholar 

Johnston M, McBride M, Dahiya D, Owusu-Apenten R, Singh Nigam P. Antibacterial activity of Manuka honey and its components: an overview. AIMS Microbiol. 2018;4:655–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Finlayson K, Teleni L, McCarthy A. Topical opioids and antimicrobials for the management of pain, infection, and infection-related odors in malignant wounds: a systematic review. Oncol Nurs Forum. 2017;44:626–32.

Article  PubMed 

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