Neinast M, Murashige D, Arany Z. Branched chain amino acids. Annu Rev Physiol. 2019;81:139–64.

Article  CAS  PubMed  Google Scholar 

Flores-Guerrero JL, Groothof D, Connelly MA, Otvos JD, Bakker SJL, Dullaart RPF. Concentration of branched-chain amino acids is a strong risk marker for incident hypertension. Hypertension (Dallas, Tex: 1979). 2019;74(6):1428–35.

Article  CAS  PubMed  Google Scholar 

Ruiz-Canela M, Toledo E, Clish CB, Hruby A, Liang L, Salas-Salvadó J, et al. Plasma branched-chain amino acids and incident cardiovascular disease in the PREDIMED trial. Clin Chem. 2016;62(4):582–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lanfear DE, Gibbs JJ, Li J, She R, Petucci C, Culver JA, et al. Targeted metabolomic profiling of plasma and survival in heart failure patients. JACC Heart Failure. 2017;5(11):823–32.

Article  PubMed  PubMed Central  Google Scholar 

Yamamoto K, Tsuchisaka A, Yukawa H. Branched-chain amino acids. Adv Biochem Eng Biotechnol. 2017;159:103–28.

CAS  PubMed  Google Scholar 

Gojda J, Cahova M. Gut Microbiota as the link between elevated BCAA serum levels and insulin resistance. Biomolecules. 2021;11(10):1414.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adeva-Andany MM, López-Maside L, Donapetry-García C, Fernández-Fernández C, Sixto-Leal C. Enzymes involved in branched-chain amino acid metabolism in humans. Amino Acids. 2017;49(6):1005–28.

Article  CAS  PubMed  Google Scholar 

Johnson WA, Connelly JL. Cellular localization and characterization of bovine liver branched-chain -keto acid dehydrogenases. Biochemistry. 1972;11(10):1967–73.

Article  CAS  PubMed  Google Scholar 

Paxton R, Harris RA. Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation. J Biol Chem. 1982;257(23):14433–9.

Article  CAS  PubMed  Google Scholar 

Pettit FH, Yeaman SJ, Reed LJ. Purification and characterization of branched chain alpha-keto acid dehydrogenase complex of bovine kidney. Proc Natl Acad Sci USA. 1978;75(10):4881–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Danner DJ, Lemmon SK, Elsas LJ 2nd. Substrate specificity and stabilization by thiamine pyrophosphate of rat liver branched chain alpha-ketoacid dehydrogenase. Biochem Med. 1978;19(1):27–38.

Article  CAS  PubMed  Google Scholar 

Lau KS, Fatania HR, Randle PJ. Regulation of the branched chain 2-oxoacid dehydrogenase kinase reaction. FEBS Lett. 1982;144(1):57–62.

Article  CAS  PubMed  Google Scholar 

Xu J, Jakher Y, Ahrens-Nicklas RC. Brain branched-chain amino acids in maple syrup urine disease: implications for neurological disorders. Int J Mol Sci. 2020;21(20):7490.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burrage LC, Nagamani SC, Campeau PM, Lee BH. Branched-chain amino acid metabolism: from rare Mendelian diseases to more common disorders. Hum Mol Genet. 2014;23(R1):R1–8.

Article  PubMed  PubMed Central  Google Scholar 

Khera AV, Kathiresan S. Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet. 2017;18(6):331–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812–23.

Article  CAS  PubMed  Google Scholar 

Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation. 2005;111(25):3481–8.

Article  PubMed  Google Scholar 

Bhattacharya S, Granger CB, Craig D, Haynes C, Bain J, Stevens RD, et al. Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization. Atherosclerosis. 2014;232(1):191–6.

Article  CAS  PubMed  Google Scholar 

Yang RY, Wang SM, Sun L, Liu JM, Li HX, Sui XF, et al. Association of branched-chain amino acids with coronary artery disease: a matched-pair case-control study. Nutr Metab, Cardiovascular Diseases: NMCD. 2015;25(10):937–42.

Article  CAS  PubMed  Google Scholar 

Yang R, Dong J, Zhao H, Li H, Guo H, Wang S, et al. Association of branched-chain amino acids with carotid intima-media thickness and coronary artery disease risk factors. PloS One. 2014;9(6):e99598.

Article  PubMed  PubMed Central  Google Scholar 

Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, et al. Ischaemic stroke. Nat Rev Dis Primers. 2019;5(1):70.

Article  PubMed  Google Scholar 

Tobias DK, Lawler PR, Harada PH, Demler OV, Ridker PM, Manson JE, et al. Circulating branched-chain amino acids and incident cardiovascular disease in a prospective cohort of US women. Circ-Genom Precis Me. 2018;11(4):e002157.

Article  CAS  Google Scholar 

Zhang Y, Duan Y, Jiang M, He X, Xu S, Guo J, et al. Branched-chain amino acids and risk of stroke: a Mendelian randomization study. Front Neurosci. 2023;17:1143718.

Article  PubMed  PubMed Central  Google Scholar 

Kimberly WT, Wang Y, Pham L, Furie KL, Gerszten RE. Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke. Stroke. 2013;44(5):1389–95.

Article  CAS  PubMed  Google Scholar 

Wu Z, Wang J, Zhang H, Pan H, Li Z, Liu Y, et al. Longitudinal association of remnant cholesterol with joint arteriosclerosis and atherosclerosis progression beyond LDL cholesterol. BMC Med. 2023;21(1):42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang Y, Zhang K, Zhu Z, Cui M, An Y, Wang Y, et al. Associations between serum metabolites and subclinical atherosclerosis in a Chinese population: the Taizhou imaging study. Aging. 2020;12(15):15302–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He L, Palos-Jasso A, Yi Y, Qin M, Qiu L, Yang X, et al. Bioinformatic analysis revealed the essential regulatory genes and pathways of early and advanced atherosclerotic plaque in humans. Cells. 2022;11(24):3976.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao S, Zhou L, Wang Q, Cao JH, Chen Y, Wang W, et al. Elevated branched-chain amino acid promotes atherosclerosis progression by enhancing mitochondrial-to-nuclear H(2)O(2)-disulfide HMGB1 in macrophages. Redox Biol. 2023;62:102696.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Zhang R, Mu H, Zhang W, Zeng J, Li H, et al. Oral administration of branched-chain amino acids attenuates atherosclerosis by inhibiting the inflammatory response and regulating the gut microbiota in ApoE-deficient mice. Nutrients. 2022;14(23):5065.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Döring Y, Soehnlein O, Weber C. Neutrophil extracellular traps in atherosclerosis and atherothrombosis. Circ Res. 2017;120(4):736–43.

Article  PubMed  Google Scholar 

Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, et al. Branched-chain amino acid catabolism promotes thrombosis risk by enhancing tropomodulin-3 propionylation in platelets. Circulation. 2020;142(1):49–64.

Article  CAS  PubMed  Google Scholar 

Du X, Li Y, Wang Y, You H, Hui P, Zheng Y, et al. Increased branched-chain amino acid levels are associated with long-term adverse cardiovascular events in patients with STEMI and acute heart failure. Life Sci. 2018;209:167–72.

Article  CAS  PubMed  Google Scholar 

Du X, You H, Li Y, Wang Y, Hui P, Qiao B, et al. Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI. Sci Rep. 2018;8(1):15809.

Article  PubMed  PubMed Central  Google Scholar 

Li T, Zhang Z, Kolwicz SC Jr, Abell L, Roe ND, Kim M, et al. Defective branched-chain amino acid catabolism disrupts glucose metabolism and sensitizes the heart to ischemia-reperfusion injury. Cell Metab. 2017;25(2):374–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang F, Hu G, Chen X, Zhang L, Guo L, Li C, et al. Excessive branched-chain amino acid accumulation restricts mesenchymal stem cell-based therapy efficacy in myocardial infarction. Signal Transduct Target Ther. 2022;7(1):171.

Article  CAS  PubMed  PubMed Central