Al-Sadi RM, Ma TY (2007) IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol 178:4641–4649. https://doi.org/10.4049/jimmunol.178.7.4641

Article  PubMed  CAS  Google Scholar 

Al-Sadi R, Ye D, Boivin M, Guo S, Hashimi M, Ereifej L, Ma TY (2014) Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PLoS ONE 9:e85345. https://doi.org/10.1371/journal.pone.0085345

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ali A, Tan H, Kaiko GE (2020) Role of the intestinal epithelium and its Interaction with the Microbiota in Food Allergy. Front Immunol 11:604054. https://doi.org/10.3389/fimmu.2020.604054

Article  PubMed  PubMed Central  CAS  Google Scholar 

Anderson JM, Van Itallie CM (2009) Physiology and function of the tight junction. Cold Spring Harb Perspect Biol 1:a002584. https://doi.org/10.1101/cshperspect.a002584

Article  PubMed  PubMed Central  Google Scholar 

Anderson RC, Cookson AL, McNabb WC, Park Z, McCann MJ, Kelly WJ, Roy NC (2010) Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation. BMC Microbiol 10:1–11

Article  Google Scholar 

Asri N, Rostami-Nejad M (2019) The facts of Celiac Disease; a Comprehensive Review. Int J Celiac Dis 7:48–52

Google Scholar 

Assémat E, Bazellières E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D (2008) Polarity complex proteins. Biochimica et Biophysica Acta (BBA) -. Biomembranes 1778:614–630. https://doi.org/10.1016/j.bbamem.2007.08.029

Article  CAS  Google Scholar 

Aydemir Y, Erdogan B, Türkeli A (2021) Vitamin D deficiency negatively affects both the intestinal epithelial integrity and bone metabolism in children with celiac Disease. Clin Res Hepatol Gastroenterol 45:101523. https://doi.org/10.1016/j.clinre.2020.08.002

Article  PubMed  CAS  Google Scholar 

Bascuñán KA, Araya M, Roncoroni L, Doneda L, Elli L (2020) Dietary gluten as a conditioning factor of the gut microbiota in Celiac Disease. Adv Nutr 11:160–174. https://doi.org/10.1093/advances/nmz080

Article  PubMed  Google Scholar 

Bazzoun D, Lelièvre S, Talhouk R (2013) Polarity proteins as regulators of cell junction complexes: implications for Breast cancer. Pharmacol Ther 138:418–427. https://doi.org/10.1016/j.pharmthera.2013.02.004

Article  PubMed  PubMed Central  CAS  Google Scholar 

Benjamin J, Makharia G, Ahuja V, Anand Rajan KD, Kalaivani M, Gupta SD, Joshi YK (2012) Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn’s Disease: a randomized controlled trial. Dig Dis Sci 57:1000–1012. https://doi.org/10.1007/s10620-011-1947-9

Article  PubMed  CAS  Google Scholar 

Braga VM, Yap AS (2005) The challenges of abundance: epithelial junctions and small GTPase signalling. Curr Opin Cell Biol 17:466–474. https://doi.org/10.1016/j.ceb.2005.08.012

Article  PubMed  CAS  Google Scholar 

Caio G, Volta U, Sapone A, Leffler DA, De Giorgio R, Catassi C, Fasano A (2019) Celiac Disease: a comprehensive current review. BMC Med 17:142. https://doi.org/10.1186/s12916-019-1380-z

Article  PubMed  PubMed Central  CAS  Google Scholar 

Capaldo CT, Nusrat A (2009) Cytokine regulation of tight junctions. Biochim Biophys Acta 1788:864–871. https://doi.org/10.1016/j.bbamem.2008.08.027

Article  PubMed  CAS  Google Scholar 

Castiglioni VG, Ramalho JJ, Kroll JR, Stucchi R, van Beuzekom H, Schmidt R et al (2022) Identification and characterization of Crumbs polarity complex proteins in Caenorhabditis elegans. J Biol Chem 298:101786. https://doi.org/10.1016/j.jbc.2022.101786

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:1–9. https://doi.org/10.1038/s12276-018-0126-x

Article  PubMed  CAS  Google Scholar 

Chen Q, Chen O, Martins IM, Hou H, Zhao X, Blumberg JB, Li B (2017) Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food Funct 8:1144–1151

Article  PubMed  CAS  Google Scholar 

Chen M, Liu Y, Xiong S, Wu M, Li B, Ruan Z, Hu X (2019) Dietary l-tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model. Food Funct 10:2390–2398. https://doi.org/10.1039/c9fo00123a

Article  PubMed  CAS  Google Scholar 

Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza GR (2006) Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac Disease. Am J Clin Pathol 125:502–511. https://doi.org/10.1309/dtyr-a91g-8r0k-tm8m

Article  PubMed  CAS  Google Scholar 

Cifuentes-Munoz N, El Najjar F, Dutch RE (2020) Viral cell-to-cell spread: Conventional and non-conventional ways. In: Margaret Kielian, Thomas C. Mettenleiter, Marilyn J. Roossinck (eds) Advances in Virus Research, Academic Press, pp. 85–125

Cukrowska B, Sowińska A, Bierła JB, Czarnowska E, Rybak A, Grzybowska-Chlebowczyk U (2017) Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - key players in the pathogenesis of celiac Disease. World J Gastroenterol 23:7505–7518. https://doi.org/10.3748/wjg.v23.i42.7505

Article  PubMed  PubMed Central  CAS  Google Scholar 

Do MH, Lee E, Oh MJ, Kim Y, Park HY (2018) High-glucose or -Fructose Diet cause changes of the gut microbiota and metabolic disorders in mice without body weight change. Nutrients 10. https://doi.org/10.3390/nu10060761

Dong S, Singh TP, Wei X, Yao H, Wang H (2018) Protective effect of 1,25-Dihydroxy vitamin D3 on pepsin-trypsin-resistant Gliadin-Induced tight Junction injuries. Dig Dis Sci 63:92–104. https://doi.org/10.1007/s10620-017-4738-0

Article  PubMed  CAS  Google Scholar 

Elias BC, Suzuki T, Seth A, Giorgianni F, Kal G, She L et al (2009) Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem 284:1559–1569. https://doi.org/10.1074/jbc.M804783200

Article  PubMed  PubMed Central  CAS  Google Scholar 

Elsum I, Yates L, Humbert PO, Richardson HE (2012) The scribble–dlg–lgl polarity module in development and cancer: from flies to man. Essays Biochem 53:141–168. https://doi.org/10.1042/bse0530141

Article  PubMed  CAS  Google Scholar 

Ewaschuk JB, Diaz H, Meddings L, Diederichs B, Dmytrash A, Backer J, Looijer-van Langen M, Madsen KL (2008) Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. Am J physiology-gastrointestinal Liver Physiol 295:G1025–G1034

Article  CAS  Google Scholar 

Fasano A (2012a) Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol 10:1096–1100. https://doi.org/10.1016/j.cgh.2012.08.012

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fasano A (2012b) Zonulin, regulation of tight junctions, and autoimmune Diseases. Ann N Y Acad Sci 1258:25–33. https://doi.org/10.1111/j.1749-6632.2012.06538.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Feigin ME, Muthuswamy SK (2009) Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol 21(5):694–700. https://doi.org/10.1016/j.ceb.2009.07.003

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao Y, Lui W-y, Lee WM, Cheng CY (2016) Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in sertoli cells. Sci Rep 6:28589. https://doi.org/10.1038/srep28589

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL (2013) Cytoskeletal proteins: shaping progression of Hepatitis C Virus-Induced Liver Disease. In: Kwang WJ (ed) International Review of Cell and Molecular Biology. Academic Press, pp 279–319

Groschwitz KR, Hogan SP (2009) Intestinal barrier function: molecular regulation and Disease pathogenesis. J Allergy Clin Immunol 124:3–20. https://doi.org/10.1016/j.jaci.2009.05.038. quiz 21-22

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hartsock A, Nelson WJ (2008) Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 1778:660–669. https://doi.org/10.1016/j.bbamem.2007.07.012

Article  PubMed  CAS  Google Scholar 

Hatzfeld M, Keil R, Magin TM (2017) Desmosomes and intermediate filaments: their consequences for tissue mechanics. Cold Spring Harb Perspect Biol 9. https://doi.org/10.1101/cshperspect.a029157

Hong Y (2018) aPKC: the kinase that phosphorylates cell polarity. F1000Res, 7. https://doi.org/10.12688/f1000research.14427.1

Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H et al (2009) Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J Cell Sci 122:1595–1606. https://doi.org/10.1242/jcs.043174

Article  PubMed  CAS  Google Scholar 

Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T et al (1998) An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol 143:95–106. https://doi.org/10.1083/jcb.143.1.95

Article