Advances in Extracellular Vesicles as Mediators of Cell-to-Cell Communication in Pregnancy

Professor Carlos Salomon (PhD, DMedSc, MSc, BSc (Hons)) Professor Salomon is the head of the Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, NHMRC Investigator Fellow and is considered a worldwide authority on Extracellular Vesicles biomarkers for complications of pregnancies and ovarian cancer (165 publications, H index 51, i10-index = 121). In the last 10 years, Professor Salomon’s primary research and commercialisation activities have focused on the identification and validation of biomarkers, and development of In Vitro Multivariate Index Assays for clinically relevant complications (including ovarian cancers, and obstetrical syndromes) and their translation into clinical applications. He is a pioneer on investigation the release of extracellular vesicles (EVs) by the placenta and tumour cells and their utility as a biomarker for a wide range of pregnancy complications and ovarian cancer (OC). Prior to his research program, the field had little understanding of the changes in circulating EVs and their content across gestation and in OC progression. In pioneering this research, his program recruited, and collected biological samples, from over 20,000 participants in multiples studies in the USA, India, Chile, UK, and Australia in the last 10 years. He has optimised methods to isolate total and placenta and tumour-derived EVs present in circulation, and profiled their content by quantitative proteomic analysis, and miRNA sequencing; identifying for the first time, molecules within EVs associated with different complications of pregnancies, and at early stages of oncogenic transformation in OC.

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