The Therapeutic Landscape in Chronic Cough

Song WJ, Chang YS, Faruqi S, Kim JY, Kang MG, Kim S et al (2015) The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur Respir J 45(5):1479–81

Article  PubMed  Google Scholar 

Colak Y, Nordestgaard BG, Laursen LC, Afzal S, Lange P, Dahl M (2017) Risk factors for chronic cough among 14,669 individuals from the general population. Chest 152(3):563–73

Article  PubMed  Google Scholar 

Morice AH, Millqvist E, Bieksiene K, Birring SS, Dicpinigaitis P, Domingo Ribas C et al (2020) ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J. https://doi.org/10.1183/13993003.01136-2019

Article  PubMed  PubMed Central  Google Scholar 

Saunders P, Wu Z, Fahy WA, Stewart ID, Saini G, Smith DJF et al (2023) The burden and impact of cough in patients with idiopathic pulmonary fibrosis: an analysis of the prospective observational PROFILE study. Ann Am Thorac Soc 20(9):1267–73

Article  PubMed  Google Scholar 

Key AL, Holt K, Hamilton A, Smith JA, Earis JE (2010) Objective cough frequency in idiopathic pulmonary fibrosis. Cough 6:4

Article  PubMed  PubMed Central  Google Scholar 

van Manen MJG, Birring SS, Vancheri C, Vindigni V, Renzoni E, Russell AM et al (2017) Effect of pirfenidone on cough in patients with idiopathic pulmonary fibrosis. Eur Respir J. https://doi.org/10.1183/13993003.01157-2017

Article  PubMed  PubMed Central  Google Scholar 

Landt E, Colak Y, Lange P, Laursen LC, Nordestgaard BG, Dahl M (2020) Chronic cough in individuals with COPD: a population-based cohort study. Chest 157(6):1446–54

Article  CAS  PubMed  Google Scholar 

Hughes R, Rapsomaniki E, Janson C, Keen C, Make BJ, Burgel PR et al (2022) Frequent productive cough: symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study. Respir Med 200:106921

Article  PubMed  Google Scholar 

Marsden PA, Smith JA, Kelsall AA, Owen E, Naylor JR, Webster D et al (2008) A comparison of objective and subjective measures of cough in asthma. J Allergy Clin Immunol 122(5):903–7

Article  PubMed  Google Scholar 

Agusti A, Bel E, Thomas M, Vogelmeier C, Brusselle G, Holgate S et al (2016) Treatable traits: toward precision medicine of chronic airway diseases. Eur Respir J 47(2):410–9

Article  PubMed  Google Scholar 

Belvisi MG, Birrell MA, Khalid S, Wortley MA, Dockry R, Coote J et al (2016) Neurophenotypes in airway diseases. Insights from translational cough studies. Am J Respir Crit Care Med 193(12):1364–72

Article  CAS  PubMed  PubMed Central  Google Scholar 

Canning BJ, Chang AB, Bolser DC, Smith JA, Mazzone SB, McGarvey L et al (2014) Anatomy and neurophysiology of cough: CHEST guideline and expert panel report. Chest 146(6):1633–48

Article  PubMed  Google Scholar 

Shapiro CO, Proskocil BJ, Oppegard LJ, Blum ED, Kappel NL, Chang CH et al (2021) Airway sensory nerve density is increased in chronic cough. Am J Respir Crit Care Med 203(3):348–55

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazzone SB, McLennan L, McGovern AE, Egan GF, Farrell MJ (2007) Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging. Am J Respir Crit Care Med 176(4):327–32

Article  PubMed  Google Scholar 

Ando A, Smallwood D, McMahon M, Irving L, Mazzone SB, Farrell MJ (2016) Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control. Thorax 71(4):323–9

Article  PubMed  Google Scholar 

Hilton E, Marsden P, Thurston A, Kennedy S, Decalmer S, Smith JA (2015) Clinical features of the urge-to-cough in patients with chronic cough. Respir Med 109(6):701–7

Article  PubMed  Google Scholar 

Young EC, Brammer C, Owen E, Brown N, Lowe J, Johnson C et al (2009) The effect of mindfulness meditation on cough reflex sensitivity. Thorax 64(11):993–8

Article  CAS  PubMed  Google Scholar 

Cho PSP, Fletcher HV, Turner RD, Jolley CJ, Birring SS (2019) Impaired cough suppression in chronic refractory cough. Eur Respir J. https://doi.org/10.1183/13993003.02203-2018

Article  PubMed  PubMed Central  Google Scholar 

Hilton E, Satia I, Holt K, Woodcock AA, Belcher J, Smith JA (2020) The effect of pain conditioning on experimentally evoked cough: evidence of impaired endogenous inhibitory control mechanisms in refractory chronic cough. Eur Respir J. https://doi.org/10.1183/13993003.01387-2020

Article  PubMed  Google Scholar 

McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J et al (2022) Efficacy and safety of gefapixant, a P2X(3) receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials. Lancet. 399(10328):909–23

Article  PubMed  Google Scholar 

Smith JA, Holt K, Dockry R, Sen S, Sheppard K, Turner P et al (2021) Performance of a digital signal processing algorithm for the accurate quantification of cough frequency. Eur Respir J. https://doi.org/10.1183/13993003.04271-2020

Article  PubMed  PubMed Central  Google Scholar 

Schelfhout J, Nguyen AM, Birring SS, Bacci ED, Vernon M, Muccino DR et al (2022) Validation and meaningful change thresholds for an objective cough frequency measurement in chronic cough. Lung. 200(6):717–24

Article  PubMed  PubMed Central  Google Scholar 

Birring SS, Prudon B, Carr AJ, Singh SJ, Morgan MD, Pavord ID (2003) Development of a symptom specific health status measure for patients with chronic cough: leicester cough questionnaire (LCQ). Thorax. 58(4):339–43

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen AM, Schelfhout J, Muccino D, Bacci ED, La Rosa C, Vernon M et al (2022) Leicester cough questionnaire validation and clinically important thresholds for change in refractory or unexplained chronic cough. Ther Adv Respir Dis 16:17534666221099736

Article  PubMed  PubMed Central  Google Scholar 

Martin Nguyen A, Bacci ED, Vernon M, Birring SS, Rosa C, Muccino D et al (2021) Validation of a visual analog scale for assessing cough severity in patients with chronic cough. Ther Adv Respir Dis 15:17534666211049744

Article  PubMed  PubMed Central  Google Scholar 

Gibson P, Wang G, McGarvey L, Vertigan AE, Altman KW, Birring SS et al (2016) Treatment of unexplained chronic cough: chest guideline and expert panel report. Chest 149(1):27–44

Article  PubMed  PubMed Central  Google Scholar 

Morice AH, Menon MS, Mulrennan SA, Everett CF, Wright C, Jackson J et al (2007) Opiate therapy in chronic cough. Am J Respir Crit Care Med 175(4):312–5

Article  CAS  PubMed  Google Scholar 

King J, Wingfield-Digby J, Hennessey S, Smith JA, Marsden PM (2022) Real world effectiveness and tolerability of low-dose opiates for refractory/unexplained chronic cough (RCC/UCC) in a tertiary clinic [abstract]. Eur Respir J 60:1159

Google Scholar 

Al-Sheklly B, Mitchell J, Issa B, Badri H, Satia I, Collier T et al (2017) Randomised control trial quantifying the efficacy of low dose morphine in a responder group of patients with refractory chronic cough [abstract]. Thorax 72:A24–A2

Google Scholar 

Wu Z, Banya W, Chaudhuri N, Jakupovic I, Maher TM, Patel B et al (2022) PAciFy cough-a multicentre, double-blind, placebo-controlled, crossover trial of morphine sulphate for the treatment of pulmonary fibrosis cough. Trials 23(1):184

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu Z, Spencer LG, Banya W, Chaudhuri N, Rivera-Ortega P, Jakupovic I et al (2023) Morphine sulfate for the treatment of cough in Idiopathic pulmonary fibrosis the PAciFy cough randomized clinical trial [abstract]. Eur Respir J 62:OA4195

Google Scholar 

Mintz S, Lee JK (2006) Gabapentin in the treatment of intractable idiopathic chronic cough: case reports. Am J Med 119(5):e13-5

Article  CAS  PubMed  Google Scholar 

Van de Kerkhove C, Goeminne PC, Van Bleyenbergh P, Dupont LJ (2012) A cohort description and analysis of the effect of gabapentin on idiopathic cough. Cough. 8(1):9

Article  PubMed  PubMed Central  Google Scholar 

Ryan NM, Birring SS, Gibson PG (2012) Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet 380(9853):1583–9

Article  CAS  PubMed  Google Scholar 

Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL (2006) Efficacy of speech pathology management for chronic cough: a randomised placebo controlled trial of treatment efficacy. Thorax 61(12):1065–9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chamberlain Mitchell SA, Garrod R, Clark L, Douiri A, Parker SM, Ellis J et al (2017) Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial. Thorax 72(2):129–36

Article  PubMed  Google Scholar 

Jeyakumar A, Brickman TM, Haben M (2006) Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. Laryngoscope 116(12):2108–12

Article  CAS 

留言 (0)

沒有登入
gif