NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke

Allen CL, Bayraktutan U (2009) Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int J Stroke 4:461–470

Article  CAS  PubMed  Google Scholar 

Arya P, Kumar U, Sharma S, Durgappa M, Guleria A, Raj R, Pande G, Kumar D (2021) Targeted NMR-based serum metabolic profiling of serine, glycine and methionine in acute-on-chronic liver failure patients: possible insights into mitochondrial dysfunction. Anal Sci Adv 2:536–545

Article  CAS  Google Scholar 

Au A (2018) Metabolomics and lipidomics of ischemic stroke. Adv Clin Chem 85:31–69

Article  CAS  Google Scholar 

Baek SH, Noh AR, Kim KA, Akram M, Shin YJ, Kim ES, Yu SW, Majid A, Bae ON (2014) Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage. Stroke 45:2438–2443

Article  PubMed  PubMed Central  Google Scholar 

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, De Ferranti SD, Floyd J, Fornage M, Gillespie C (2017) Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation 135:e146–e603

Article  PubMed  PubMed Central  Google Scholar 

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R (2018) Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation 137:e67–e492

Article  PubMed  Google Scholar 

Biran V, Cochois V, Karroubi A, Arrang JM, Charriaut-Marlangue C, Heron A (2008) Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain. Brain Pathol 18(1):1–9

Article  CAS  PubMed  Google Scholar 

Carinci M, Vezzani B, Patergnani S, Ludewig P, Lessmann K, Magnus T, Casetta I, Pugliatti M, Pinton P, Giorgi C (2021) Different roles of mitochondria in cell death and inflammation: focusing on mitochondrial quality control in ischemic stroke and reperfusion. Biomedicines 9:169

Article  CAS  PubMed  Google Scholar 

Chan PH (2005) Mitochondrial dysfunction and oxidative stress as determinants of cell death/survival in stroke. Ann N Y Acad Sci 1042:203–209

Article  CAS  PubMed  Google Scholar 

Chei CL, Yamagishi K, Kitamura A, Kiyama M, Imano H, Ohira T, Cui R, Tanigawa T, Sankai T, Ishikawa Y (2013) High-density lipoprotein subclasses and risk of stroke and its subtypes in Japanese population: the Circulatory Risk in Communities Study. Stroke 44:327–333

Article  CAS  PubMed  Google Scholar 

Chen HJ, Shen YC, Lin CY, Tsai KC, Lu CK, Shen CC, Lin YL (2012) Metabolomics study of Buyang Huanwu Tang Decoction in ischemic stroke mice by 1 H NMR. Metabolomics 8:974–984

Article  CAS  Google Scholar 

Chen S, Dong Z, Zhao Y, Sai N, Wang X, Liu H, Huang G, Zhang X (2017) Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain. Sci Rep 7:6932

Article  PubMed Central  Google Scholar 

Demine S, Reddy N, Renard P, Raes M, Arnould T (2014) Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches. Metabolites 4:831–878

Article  CAS  PubMed  PubMed Central  Google Scholar 

Durand P, Prost M, Loreau N, Lussier-Cacan S, Blache D (2001) Impaired homocysteine metabolism and atherothrombotic disease. Lab Invest 81:645–672

Article  CAS  PubMed  Google Scholar 

Fowler B (2005) Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin Vasc Med 5(02):77–86 (Copyright-¬ 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New-áª. Ref Type: Conference Proceeding)

Article  PubMed  Google Scholar 

Gao J, Yang H, Chen J, Fang J, Chen C, Liang R, Yang G, Wu H, Wu C, Li S (2013) Analysis of serum metabolites for the discovery of amino acid biomarkers and the effect of Galangin on cerebral ischemia. Mol BioSyst 9:2311–2321

Article  CAS  PubMed  Google Scholar 

Geisler S, Gostner JM, Becker K, Ueberall F, Fuchs D (2013) Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio. Pteridines 24:27–31

Article  CAS  Google Scholar 

Gibney MJ, Walsh M, Brennan L, Roche HM, German B, Van Ommen B (2005) Metabolomics in human nutrition: opportunities and challenges. Am J Clin Nutr 82:497–503

Article  CAS  PubMed  Google Scholar 

Glushakova OY, Glushakov AV, Miller ER, Valadka AB, Hayes RL (2016) Biomarkers for acute diagnosis and management of stroke in neurointensive care units. Brain Circ 2:28

Article  PubMed  PubMed Central  Google Scholar 

Gowda GN, Zhang S, Gu H, Asiago V, Shanaiah N, Raftery D (2008) Metabolomics-based methods for early disease diagnostics. Expert Rev Mol Diagn 8:617–633

Article  CAS  PubMed  Google Scholar 

Grandizoli CW, Lange MC, Novak F, Campos FR, Barison A (2014) Ischemic stroke progress evaluation by 31P NMR-based metabonomic of human serum. J Braz Chem Soc 25:1143–1149

CAS  Google Scholar 

Guleria A, Kumar A, Kumar U, Raj R, Kumar D (2018) NMR based metabolomics: an exquisite and facile method for evaluating therapeutic efficacy and screening drug toxicity. Curr Top Med Chem 18:1827–1849

Article  CAS  PubMed  Google Scholar 

Gupta S, Sharma U (2021) Metabolomics of neurological disorders in India. Anal Sci Adv 2:594–610

Article  Google Scholar 

Gupta N, Yadav DK, Gautam S, Kumar A, Kumar D, Prasad N (2023) Nuclear magnetic resonance-based metabolomics approach revealed the intervention effect of using Complementary and Alternative Medicine (CAM) by CKD patients. ACS Omega 8:7722–7737

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirasawa N (2019) Expression of histidine decarboxylase and its roles in inflammation. Int J Mol Sci 20:376

Article  PubMed  PubMed Central  Google Scholar 

Holecek M (2020) Histidine in health and disease: metabolism, physiological importance, and use as a supplement. Nutrients 12:848

Article  CAS  PubMed  PubMed Central  Google Scholar 

Howard VJ, Sides EG, Newman GC, Cohen SN, Howard G, Malinow MR, Toole JF (2002) Changes in plasma homocyst (e) ine in the acute phase after stroke. Stroke 33:473–478

Article  CAS  Google Scholar 

Iso H, Sato S, Umemura U, Kudo M, Koike K, Kitamura A, Imano H, Okamura T, Naito Y, Shimamoto T (2002) Linoleic acid, other fatty acids, and the risk of stroke. Stroke 33:2086–2093

Article  CAS  PubMed  Google Scholar 

Jayachitra S, Prasanth A (2021) Multi-feature analysis for automated brain stroke classification using weighted Gaussian naive Bayes classifier. J Circ Syst Comput 30:2150178

Article  Google Scholar 

Jia J, Zhang H, Liang X et al (2021) Application of Metabolomics to the Discovery of Biomarkers for Ischemic Stroke in the Murine Model: a Comparison with the Clinical Results. Mol Neurobiol 58:6415–6426. https://doi.org/10.1007/s12035-021-02535-2

Article  CAS  PubMed  Google Scholar 

Jung JY, Lee HS, Kang DG, Kim NS, Cha MH, Bang OS, Ryu DH, Hwang GS (2011) 1H-NMR-based metabolomics study of cerebral infarction. Stroke 42:1282–1288

Article  CAS  PubMed  Google Scholar 

Koek MM, Jellema RH, van der Greef J, Tas AC, Hankemeier T (2011) Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives. Metabolomics 7:307–328

Article  CAS  PubMed  Google Scholar 

Kumar U, Jain A, Guleria A, Misra DP, Goel R, Danda D, Misra R, Kumar D (2020) Circulatory glutamine/glucose ratio for evaluating disease activity in Takayasu arteritis: a NMR based serum metabolomics study. J Pharm Biomed Anal 180:113080

Article  CAS  PubMed  Google Scholar 

Kusum K, Raj R, Rai S, Pranjali P, Ashish A, Vicente-Muñoz S, Chaube R, Kumar D (2022) Elevated Circulatory Proline to Glutamine Ratio (PQR) in endometriosis and its potential as a diagnostic biomarker. ACS Omega 7(17):14856–14866

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee Y, Khan A, Hong S, Jee SH, Park YH (2017) A metabolomic study on high-risk stroke patients determines low levels of serum lysine metabolites: a retrospective cohort study. Mol BioSyst 13:1109–1120

Article  CAS  PubMed  Google Scholar 

Li N, Kong X, Ye R, Yang Q, Han J, Xiong L (2011) Age-related differences in experimental stroke: possible involvement of mitochondrial dysfunction and oxidative damage. Rejuvenation Res 14:261–273

Article  CAS  PubMed  Google Scholar 

Li Q, Zhang T, Wang J, Zhang Z, Zhai Y, Yang GY, Sun X (2014) Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke. Biochem Biophys Res Commun 444:182–188

Article  CAS  PubMed  Google Scholar 

Li W, Shao

留言 (0)

沒有登入
gif