Hunter D.R., Haworth R.A. 1979. The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ release. Arch. Biochem. Biophys. 195 (2), 468–477.

Article  CAS  PubMed  Google Scholar 

Crompton M., Ellinger H., Costi A. 1988. Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem. J. 255, 357–360.

CAS  PubMed  PubMed Central  Google Scholar 

Bernardi P., Broekemeir K.M., Pfeiffer D.R. 1994. Recent progress on regulation of the mitochondrial permeability transition pore; A cyclosporine-sensitive pore in the inner mitochondrial membrane. J. Bioenerg. Biomembr. 26 (5), 509–517. https://doi.org/10.1007/BF00762735

Article  CAS  PubMed  Google Scholar 

Kwong J.Q., Molkentin J.D. 2015. Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell Metab. 21 (2), 206. https://doi.org/10.1016/j.cmet.2014.12.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ford D.A., Han X., Horner C.C., Gross W. 1996. Accumulation of unsaturated acylcarnitine molecular species during acute myocardial ischemia: Metabolic compartmentalization of products of fatty acyl chain elongation in the acylcarnitine pool. Biochemistry. 35 (24), 7903. https://doi.org/10.1021/bi960552n

Article  CAS  PubMed  Google Scholar 

Lesnefsky E.J., Moghaddas S., Tandler B., Kerner J., Hoppel C.L. 2001. Mitochondrial dysfunction in cardiac disease: Ischemia–reperfusion, aging, and heart failure. J. Mol. Cell Cardiol. 33 (6), 1065–1089. https://doi.org/10.1006/jmcc.2001.1378

Article  CAS  PubMed  Google Scholar 

Koves T.R., Ussher J.R., Noland R.C., Slentz D., Mosedale M., Ilkayeva O., Bain J., Stevens R., Dyck J.R., Newgard C.B., Lopaschuk G.D., Muoio D.M. 2008. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7 (1), 45–56. https://doi.org/10.1016/j.cmet.2007.10.013

Article  CAS  PubMed  Google Scholar 

Fromenty B., Robin M.A., Igoudjil A., Mansouri A., Pessayre D. 2004. The ins and outs of mitochondrial dysfunction in NASH. Diabetes Metab. 30 (2), 121–138. https://doi.org/10.1016/s1262-3636(07)70098-8

Article  CAS  PubMed  Google Scholar 

Liepinsh E., Makrecka-Kuka M., Volska K., Kuka J., Makarova E., Antone U., Sevostjanovs E., Vilskersts R., Strods A., Tars K., Dambrova M. 2016. Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. Biochem. J. 473 (9), 1191–1202. https://doi.org/10.1042/BCJ20160164

Article  CAS  PubMed  Google Scholar 

Erfle J.D., Sauer F. 1969. The inhibitory effects of acyl-coenzyme A esters on the pyruvate and alpha-oxoglutarate dehydrogenase complexes. Biochim. Biophys. Acta. 178 (3), 441–452. https://doi.org/10.1016/0005-2744(69)90213-7

Article  CAS  PubMed  Google Scholar 

Lai J.C., Cooper A.J. 1991. Neurotoxicity of ammonia and fatty acids: Differential inhibition of mitochondrial dehydrogenases by ammonia and fatty acyl coenzyme A derivatives. Neurochem. Res. 16 (7), 795–803.

Article  CAS  PubMed  Google Scholar 

Farrell H.M. Jr, Wickham E.D., Reeves H.C. 1995. Effects of long-chain acyl-coenzyme A’s on the activity of the soluble form of nicotinamide adenine dinucleotide phosphate-specific isocitrate dehydrogenase from lactating bovine mammary gland. Arch. Biochem. Biophys. 321 (1), 199–208. https://doi.org/10.1006/abbi.1995.1386

Article  CAS  PubMed  Google Scholar 

Paulson D.J., Shug A.L. 1984. Inhibition of the adenine nucleotide translocator by matrix-localized palmityl-CoA in rat heart mitochondria. Biochim. Biophys. Acta. 766 (1), 70–76. https://doi.org/10.1016/0005-2728(84)90218-4.10

Article  CAS  PubMed  Google Scholar 

Schoënfeld P., Bohnensack R. 1997. Fatty acid-promoted mitochondrial permeability transition by membrane depolarization and binding to the ADP/ATP carrier. FEBS Letters. 420, 167–170.

Article  Google Scholar 

Ciapaite J., Van Eikenhorst D., Bakker S., Diamant M., Heine R.J., Wagner M.J., Westerhoff H.V., Krab K. 2005. Modular kinetic analysis of the adenine nucleotide translocator-mediated effects of palmitoyl-CoA on the oxidative phosphorylation in isolated rat liver mitochondria. Diabetes. 54 (4), 944–951. https://doi.org/10.2337/diabetes.54.4.944

Article  CAS  PubMed  Google Scholar 

Wojtczak L., Wieckowski M.R. 1999. The mechanisMC of fatty acid-induced proton permeability of the inner mitochondrial membrane. J. Bioenerg. Biomembr. 31, 447–455.

Article  CAS  PubMed  Google Scholar 

Sultan A., Sokolove P.M. 2001. Palmitic acid opens a novel cyclosporin A-insensitive pore in the inner mitochondrial membrane. Arch. Biochem. Biophys. 386 (1), 37–51. https://doi.org/10.1006/abbi.2000.2194

Article  CAS  PubMed  Google Scholar 

Mironova G. D., Gateau-Roesch O., Levrat C., Gritsenko E., Pavlov E., Lazareva A.V., Limarenko E., Rey C., Louisot P., Saris N.E. 2001. Palmitic and stearic acids bind Ca2+ with high affinity and form nonspecific channels in black-lipid membranes. Possible relation to Ca2+-activated mitochondrial pores. J. Bioenerg. Biomembr. 33 (4), 319–331. https://doi.org/10.1023/a:1010659323937

Article  CAS  PubMed  Google Scholar 

Mironova G.D., Pavlov E.V. 2021. Mitochondrial cyclosporine A-independent palmitate/Ca2+-induced permeability transition pore (PA-mPT Pore) and its role in mitochondrial function and protection against calcium overload and glutamate toxicity. Cells. 10, 125. https://doi.org/10.3390/cells10010125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fedotcheva N.I., Grishina E.V., Dynnik V.V. 2022. Induction of mitochondrial cyclosporine-dependent pores by acylcarnitines. Influence of the concentration and length of the carbon chain. Biologicheskie membrany (Rus.). 39 (1), 75–82. https://doi.org/10.31857/S0233475522010066

Dynnik V.V., Grishina E.V., Fedotcheva N.I. 2020. The mitochondrial NO-synthase/guanylate cyclase/protein kinase G signaling system underpins the dual effects of nitric oxide on mitochondrial respiration and opening of the permeability transition pore. FEBS J. 287 (8), 1525–1536. https://doi.org/10.1111/febs.15090

Article  CAS  PubMed  Google Scholar 

Berezhnov A.V., Fedotova E.I., Nenov M.N., Kasymov V.A., Pimenov O.Y., Dynnik V.V. 2020. Dissecting cellular mechanisMC of long-chain acylcarnitines-driven cardiotoxicity: Disturbance of calcium homeostasis, activation of Ca2+-dependent phospholipases, and mitochondrial energetics collapse. Int. J. Mol. Sci. 21 (20), 7461. https://doi.org/10.3390/ijMC21207461

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hollander J.M., Thapa D., Shepherd D.L. 2014. Physiological and structural differences in spatially distinct subpopulations of cardiac mitochondria: Influence of cardiac pathologies. Am. J. Physiol. Circ. Physiol. 307, H1–H14. https://doi.org/10.1152/ajpheart.00747.2013

Article  CAS  Google Scholar 

Caro A.A., Cederbaum A.I. 2007. Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1. Arch. Biochem. Biophys. 457 (2), 252–263. https://doi.org/10.1016/j.abb.2006.10.018

Article  CAS  PubMed  Google Scholar 

Saito Y., Watanabe K., Fujioka D., Nakamura T., Obata J., Kawabata K., Watanabe Y., Mishina H., Tamaru S., Kita Y., Shimizu T., Kugiyama K. 2012. Disruption of group IVA cytosolic phospholipase A2 attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway. Am. J. Physiol. Circ. Physiol. 302, H2018–H2030. https://doi.org/10.1152/ajpheart.00955.2011

Article  CAS  Google Scholar 

Asemu G., Dhalla N.S., Tappia P.S. 2004. Inhibition of PLC improves postischemic recovery in isolated rat heart. Am. J. Physiol. Circ. Physiol. 287 (6), H2598–H2605. https://doi.org/10.1152/ajpheart.00506.2004

Article  CAS  Google Scholar 

Hara S., Yoda E., Sasaki Y., Nakatani Y., Kuwata H. 2019. Calcium-independent phospholipase A2γ (iPLA2γ) and its roles in cellular functions and diseases. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids. 1864 (6), 861–868. https://doi.org/10.1016/j.bbalip.2018.10.009

Moon S.H., Jenkins C.M., Liu X., Guan S., Mancuso D.J., Gross R.W. 2012. Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids. J. Biol. Chem. 287 (18), 14 880–14 895. https://doi.org/10.1074/jbc.M111.336776

Article  CAS  Google Scholar 

Kinsey G.R., Blum J.L., Covington M.D., Cummings B.S., McHowat J., Schnellmann R. 2008. Decreased iPLA-2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis. J. Lipid Res. 49 (7), 1477–1487. https://doi.org/10.1194/jlr.M800030-JLR200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kinsey G.R., McHowat J., Patrick K.S., Schnellmann R.G. 2007. Role of Ca2+-independent phospholipase A2gamma in Ca2+-induced mitochondrial permeability transition. J. Pharmacol. Exp. Ther. 321 (2), 707–715. https://doi.org/10.1124/jpet.107.119545

Article  CAS  PubMed  Google Scholar 

Rauckhorst A.J., Broekemeier K.M., Pfeiffer D.R. 2014. Regulation of the Ca2+-independent phospholipase A2 in liver mitochondria by changes in the energetic state. J. Lipid Res. 55 (5), 826–836. https://doi.org/10.1194/jlr.M043307

Article  CAS  PubMed  PubMed Central  Google Scholar 

WilliaMC S.D., Gottlieb R.A. 2002. Inhibition of mitochondrial calcium-independent phospholipase A2 (iPLA2) attenuates mitochondrial phospholipid loss and is cardioprotective. Biochem. J. 362 (Pt 1), 23–32. https://doi.org/10.1042/0264-6021:3620023

Article  Google Scholar 

Moon S.H., Jenkins C.M., Kiebish M.A., SiMC H.F., Mancuso D.J., Gross R.W. 2012. Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release. J. Biol. Chem. 287 (35), 29837–29850.https://doi.org/10.1074/jbc.M112.373654

Article  CAS  PubMed  PubMed Central