Kannel WB, Sorlie P, McNamara PM. Prognosis after initial myocardial infarction: the Framingham study. Am J Cardiol. 1979;44:53–9.

Article  CAS  PubMed  Google Scholar 

Virani SS, Alonso A, Benjamin EJ, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141:e139–596.

Article  PubMed  Google Scholar 

Talman V, Ruskoaho H. Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration. Cell Tissue Res. 2016;365:563–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ertl G, Frantz S. Healing after myocardial infarction. Cardiovasc Res. 2005;66:22–32.

Article  CAS  PubMed  Google Scholar 

Frantz S, Hundertmark MJ, Schulz-Menger J, Bengel FM, Bauersachs J. Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies. Eur Heart J. 2022;43(27):2549–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. CardiovascRes. 2007;74:184–95.

Article  CAS  Google Scholar 

Bujak M, Ren G, Kweon HJ, et al. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation. 2007;116:2127–38.

Article  CAS  PubMed  Google Scholar 

Matsui Y, Morimoto J, Uede T. Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction. World J Biol Chem. 2010;1:69–80.

Article  PubMed  PubMed Central  Google Scholar 

Lamouille S, Mallet C, Feige J-J, et al. Activin receptor–like kinase 1 is implicated in the maturation phase of angiogenesis. Blood. 2002;100:4495–501.

Article  CAS  PubMed  Google Scholar 

Oh SP, Seki T, Goss KA, et al. Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000;97:2626–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson DW, Berg JN, Baldwin MA, et al. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. Nat Genet. 1996;13:189–95.

Article  CAS  PubMed  Google Scholar 

Leask A. Getting to the heart of the matter. Circ Res. 2015;116:1269–76.

Article  CAS  PubMed  Google Scholar 

Morine KJ, Qiao X, Paruchuri V, et al. Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure. CardiovascPathol. 2017;31:26–33.

CAS  Google Scholar 

Morine KJ, Qiao X, York S, et al. Bone morphogenetic protein 9 reduces cardiac fibrosis and improves cardiac function in heart failure. Circulation. 2018;138:513–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández B, Durán AC, Fernández MC, et al. The coronary arteries of the C57BL/6 mouse strains: implications for comparison with mutant models. J Anat. 2008;212:12–8.

Article  PubMed  PubMed Central  Google Scholar 

Scalise RFM, De Sarro R, Caracciolo A, et al. Fibrosis after myocardial infarction: an overview on cellular processes, molecular pathways, clinical evaluation and prognostic value. Med Sci. 2021;9:16.

CAS  Google Scholar 

Bhave S, Esposito M, Swain L, et al. Loss of bone morphogenetic protein-9 reduces survival and increases MMP activity after myocardial infarction. JACC Basic Transl Sci. 2023;8:1318–30.

Article  Google Scholar 

Sullivan KE, Quinn KP, Tang KM, et al. Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells. Stem Cell Res Ther. 2014;5:14.

Article  PubMed  PubMed Central  Google Scholar 

David L, Mallet C, Mazerbourg S, et al. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953–61.

Article  CAS  PubMed  Google Scholar 

Scharpfenecker M, Floot B, Russell NS, et al. The TGF-Î2 co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney. RadiotherOncol. 2012;105:313–20.

CAS  Google Scholar 

Wu X, Reboll MR, Korf-Klingebiel M, et al. Angiogenesis after acute myocardial infarction. Cardiovasc Res. 2021;117:1257–73.

Article  CAS  PubMed  Google Scholar 

Sánchez-Elsner T, Botella LM, Velasco B, et al. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-β pathways*. J Biol Chem. 2002;277:43799–808.

Article  PubMed  Google Scholar 

Shao ES, Lin L, Yao Y, et al. Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells. Blood. 2009;114:2197–206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McDonald J, Bayrak-Toydemir P, DeMille D, et al. Curaçao diagnostic criteria for hereditary hemorrhagic telangiectasia is highly predictive of a pathogenic variant in ENG or ACVRL1 (HHT1 and HHT2). Genet Med. 2020;22:1201–5.

Article  CAS  PubMed  Google Scholar 

Hu X, Dai S, Wu W-J, et al. Stromal cell–derived factor-1α confers protection against myocardial ischemia/reperfusion injury. Circulation. 2007;116:654–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saxena A, Fish JE, White MD, et al. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation. 2008;117:2224–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiasa K, Ishibashi M, Ohtani K, et al. Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization. Circulation. 2004;109:2454–61.

Article  CAS  PubMed  Google Scholar 

Yamaguchi J, Kusano KF, Masuo O, et al. Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation. 2003;107:1322–8.

Article  CAS  PubMed  Google Scholar 

Young K, Conley B, Romero D, et al. BMP9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood. 2012;120:4263–73.

Article  CAS  PubMed  PubMed Central  Google Scholar