Steyn FJ, Tolle V, Chen C, Epelbaum J. Neuroendocrine regulation of growth hormone secretion. Compr Physiol. 2016;6:687–735.

Article  PubMed  Google Scholar 

Murray PG, Higham CE, Clayton PE. 60 years of neuroendocrinology: the hypothalamo-GH axis: the past 60 years. J Endocrinol. 2015;226:T123–40.

Article  CAS  PubMed  Google Scholar 

Ojeda SR, Jameson HE. Developmental patterns of plasma and pituitary growth hormone (GH) in the female rat. Endocrinology. 1977;100:881–9.

Article  CAS  PubMed  Google Scholar 

Pivonello R, Auriemma RS, Grasso LF, Pivonello C, Simeoli C, Patalano R, Galdiero M, Colao A. Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities. Pituitary. 2017;20:46–62.

Article  PubMed  Google Scholar 

Dehkhoda F, Lee CMM, Medina J, Brooks AJ. The growth hormone receptor: mechanism of receptor activation, Cell Signaling, and physiological aspects. Front Endocrinol (Lausanne). 2018;9:35.

Article  PubMed  Google Scholar 

List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology. 2014;155:1793–805.

Article  PubMed Central  PubMed  Google Scholar 

Sharma R, Kopchick JJ, Puri V, Sharma VM. Effect of growth hormone on insulin signaling. Mol Cell Endocrinol. 2020;518:111038.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Kopchick JJ, Berryman DE, Puri V, Lee KY, Jorgensen JOL. The effects of growth hormone on adipose tissue: old observations, new mechanisms. Nat Rev Endocrinol. 2020;16:135–46.

Article  PubMed  Google Scholar 

Wasinski F, Klein MO, Bittencourt JC, Metzger M, Donato J Jr. Distribution of growth hormone-responsive cells in the brain of rats and mice. Brain Res. 2021;1751:147189.

Article  CAS  PubMed  Google Scholar 

Furigo IC, Metzger M, Teixeira PD, Soares CR, Donato J Jr. Distribution of growth hormone-responsive cells in the mouse brain. Brain Struct Funct. 2017;222:341–63.

Article  CAS  PubMed  Google Scholar 

Zhai Q, Lai Z, Roos P, Nyberg F. Characterization of growth hormone binding sites in rat brain. Acta Paediatr. 1994;406:92–5.

Article  CAS  Google Scholar 

de Lima JBM, Debarba LK, Rupp AC, Qi N, Ubah C, Khan M, Didyuk O, Ayyar I, Koch M, Sandoval DA, Sadagurski M. ARC(GHR) neurons regulate muscle glucose uptake. Cells. 2021;10:1093.

Article  PubMed Central  PubMed  Google Scholar 

Rogers KV, Vician L, Steiner RA, Clifton DK. The effect of hypophysectomy and growth hormone administration on pre-prosomatostatin messenger ribonucleic acid in the periventricular nucleus of the rat hypothalamus. Endocrinology. 1988;122:586–91.

Article  CAS  PubMed  Google Scholar 

Tannenbaum GS, Guyda HJ, Posner BI. Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain. Science. 1983;220:77–9.

Article  CAS  PubMed  Google Scholar 

Brown-Borg HM. Hormonal control of aging in rodents: the somatotropic axis. Mol Cell Endocrinol. 2009;299:64–71.

Article  CAS  PubMed  Google Scholar 

de Paula DG, Bohlen TM, Zampieri TT, Mansano NS, Vieira HR, Gusmao DO, Wasinski F, Donato J Jr., Frazao R. Distinct effects of growth hormone deficiency and disruption of hypothalamic kisspeptin system on reproduction of male mice. Life Sci. 2021;285:119970.

Article  PubMed  Google Scholar 

Bohlen TM, Zampieri TT, Furigo IC, Teixeira PD, List EO, Kopchick J, Donato J Jr., Frazao R. Central growth hormone signaling is not required for the timing of puberty. J Endocrinol. 2019;243:161–73.

Article  CAS  Google Scholar 

Silveira MA, Zampieri TT, Furigo IC, Abdulkader F, Donato J Jr., Frazao R. Acute effects of somatomammotropin hormones on neuronal components of the hypothalamic-pituitary-gonadal axis. Brain Res. 2019;1714:210–7.

Article  CAS  PubMed  Google Scholar 

Wasinski F, Chaves FM, Pedroso JAB, Mansano NS, Camporez JP, Gusmao DO, List EO, Kopchick JJ, Frazao R, Szawka RE, Donato J. Jr. Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice. J Neuroendocrinol. 2021;33:e12957.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Le Greves M, Steensland P, Le Greves P, Nyberg F. Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-D-aspartate receptor subunits gene transcripts in male rats. Proc Natl Acad Sci U S A. 2002;99:7119–23.

Article  PubMed Central  PubMed  Google Scholar 

Mahmoud GS, Grover LM. Growth hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus. J Neurophysiol. 2006;95:2962–74.

Article  CAS  PubMed  Google Scholar 

Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiol Aging. 2012;33:1938–49.

Article  CAS  PubMed  Google Scholar 

Nyberg F, Hallberg M. Growth hormone and cognitive function. Nat Rev Endocrinol. 2013;9:357–65.

Article  CAS  PubMed  Google Scholar 

Ramis M, Sarubbo F, Sola J, Aparicio S, Garau C, Miralles A, Esteban S. Cognitive improvement by acute growth hormone is mediated by NMDA and AMPA receptors and MEK pathway. Prog Neuropsychopharmacol Biol Psychiatry. 2013;45:11–20.

Article  CAS  PubMed  Google Scholar 

Furigo IC, Melo HM, Lyra ESNM, Ramos-Lobo AM, Teixeira PDS, Buonfiglio DC, Wasinski F, Lima ER, Higuti E, Peroni CN, Bartolini P, Soares CRJ, Metzger M, de Felice FG, Donato J. Jr. Brain STAT5 signaling modulates learning and memory formation. Brain Struct Funct. 2018;223:2229–41.

Article  CAS  PubMed  Google Scholar 

Molina DP, Ariwodola OJ, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age (Dordr). 2013;35:1575–87.

Article  CAS  PubMed  Google Scholar 

Le Greves M, Le Greves P, Nyberg F. Age-related effects of IGF-1 on the NMDA-, GH- and IGF-1-receptor mRNA transcripts in the rat hippocampus. Brain Res Bull. 2005;65:369–74.

Article  PubMed  Google Scholar 

Fleming T, Martinez-Moreno CG, Carranza M, Luna M, Harvey S, Aramburo C. Growth hormone promotes synaptogenesis and protects neuroretinal dendrites against kainic acid (KA) induced damage. Gen Comp Endocrinol. 2018;265:111–20.

Article  CAS  PubMed  Google Scholar 

Scheepens A, Sirimanne ES, Breier BH, Clark RG, Gluckman PD, Williams CE. Growth hormone as a neuronal rescue factor during recovery from CNS injury. Neuroscience. 2001;104:677–87.

Article  CAS  PubMed  Google Scholar 

Aberg ND, Brywe KG, Isgaard J. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. ScientificWorldJournal. 2006;6:53–80.

Article  PubMed Central  PubMed  Google Scholar 

Baltazar-Lara R, Zenil JM, Carranza M, Avila-Mendoza J, Martinez-Moreno CG, Aramburo C, Luna M. Growth hormone (GH) crosses the blood-brain barrier (BBB) and induces neuroprotective effects in the embryonic chicken cerebellum after a hypoxic Injury. Int J Mol Sci. 2022;23:11546.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Bianchi VE, Locatelli V, Rizzi L. Neurotrophic and neuroregenerative effects of GH/IGF1. Int J Mol Sci. 2017;18:2441.

Article  PubMed Central  PubMed  Google Scholar 

Hascup KN, Lynn MK, Fitzgerald PJ, Randall S, Kopchick JJ, Boger HA, Bartke A, Hascup ER. Enhanced cognition and Hypoglutamatergic Signaling in a growth hormone receptor knockout mouse model of successful aging. J Gerontol A Biol Sci Med Sci. 2017;72:329–37.

CAS  PubMed  Google Scholar 

Basu A, McFarlane HG, Kopchick JJ. Spatial learning and memory in male mice with altered growth hormone action. Horm Behav. 2017;93:18–30.

Article  CAS  PubMed  Google Scholar 

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Abeta oligomers. J Clin Invest. 2012;122:1339–53.

Article  CAS  PubMed Central  PubMed  Google Scholar 

Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE. Demonstrated brain insulin resistance in Alzheimer’s Disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 2012;122:1316–38.

Article