Liver transplantation continues to be the definitive treatment option for decompensated end-stage liver disease. Since the first successful liver transplant in 1967,1 there have been tremendous medical and surgical advances that have dramatically improved outcomes after liver transplant (LT).2 Despite LT recipients becoming increasingly more ill at the time of transplant, recently reported patient survival rates in the United States are 93.6% at 1 year and 86.9% at 3 years after LT.2 Developments in radiologic techniques and image-guided interventions have significantly enhanced our ability to detect and manage post-LT complications and have contributed to improved outcomes. Successful management of post-LT complications requires a close partnership between surgeons and interventional radiologists (IR) to diagnose and manage complications expeditiously. In this review, we will discuss our approach to managing post-LT vascular and biliary complications using surgical or image-guided interventions.