Document Type : Original Research Article

Authors

1 Department of chemical engineering, AL-Nisour University College, Baghdad, Iraq

2 Department of Pharmacy, Al-Noor University College, Nineveh, Iraq

3 Department of Pharmacy, Al-Hadi University College, Baghdad, 10011, Iraq

4 Department of Pharmacy, Mazaya University College, Iraq

5 Department of Pharmacy, Al-Esraa University College, Baghdad, Iraq

6 Department of Chemistry, College of Pharmacy/ National University of Science and Technology, Dhi Qar, Iraq

Abstract

This method was based on the use of the diazotization method as a simple and sensitive method, easy spectrophotometric way for the determination of Mogadon drug or called Nitrazepam (NZP) in pharmaceutical tablets. This way depends upon the reduction of the nitro to amino group, react with reagent catechol to form a color complex with best maximum absorption at 463 nm. The optimal conditions for an experiment were studied: such as Effect of base volume, Effect of kind and acid volume, contact time, and temperature. The spectrophotometric way has been successfully useful to determine NZP in pharmaceutical tablets. the best absorbance as optimal volume NaOH at 1 mL and 1mL HCL. optimal time required to complete the azo coupling reaction was found to be 3 min. for NZP drug. Where the range concentration 1-20 mg / 10 ml, it was it obeys Lambert Beer Law Correlation coefficient (R2 =0.9982). The selectivity of the suggested way, the influence of number of some materials foreign (like lactose, starch, glucose, dextrose). The data show that the examined interferences non overlap with suggested method. The recovery of NZP drug in tablets to range (96% -100.1 %). The statistical result compared with these found by a way reported in literature. This method simple, sensitive, and selective, can be utilized about control analysis to Determination drug.

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