Diaz-Arrastia R, et al. Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup. J Neurotrauma. 2014;31(2):135–58.

Article  PubMed  PubMed Central  Google Scholar 

Barkhoudarian G, Hovda DA, Giza CC. The molecular pathophysiology of concussive brain injury - an update. Phys Med Rehabil Clin N Am. 2016;27(2):373–93.

Article  PubMed  Google Scholar 

Corps KN, Roth TL, McGavern DB. Inflammation and neuroprotection in traumatic brain injury. JAMA Neurol. 2015;72(3):355–62.

Article  PubMed  PubMed Central  Google Scholar 

Giza C, Greco T, Prins ML. Concussion: pathophysiology and clinical translation. Handb Clin Neurol. 2018;158:51–61.

Article  PubMed  Google Scholar 

Faden AI, Loane DJ. Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation? Neurotherapeutics. 2015;12(1):143–50.

Article  CAS  PubMed  Google Scholar 

LoBue C, et al. Traumatic brain injury and risk of long-term brain changes, accumulation of pathological markers, and developing dementia: a review. J Alzheimers Dis. 2019;70(3):629–54.

Article  CAS  PubMed  Google Scholar 

Vaishnavi S, Rao V, Fann JR. Neuropsychiatric problems after traumatic brain injury: unraveling the silent epidemic. Psychosomatics. 2009;50(3):198–205.

Article  PubMed  Google Scholar 

Wilson L, et al. The chronic and evolving neurological consequences of traumatic brain injury. Lancet Neurol. 2017;16(10):813–25.

Article  PubMed  PubMed Central  Google Scholar 

Capettini LS, et al. Role of renin-angiotensin system in inflammation, immunity and aging. Curr Pharm Des. 2012;18(7):963–70.

Article  CAS  PubMed  Google Scholar 

Perrone-Filardi P, et al. Renin-angiotensin-aldosterone system inhibition in patients affected by heart failure: efficacy, mechanistic effects and practical use of sacubitril/valsartan. Position Paper of the Italian Society of Cardiology. Eur J Intern Med. 2022;102:8–16.

Article  CAS  PubMed  Google Scholar 

Savoia C, et al. Angiotensin II and the vascular phenotype in hypertension. Expert Rev Mol Med. 2011;13: e11.

Article  PubMed  Google Scholar 

Thone-Reineke C, Steckelings UM, Unger T. Angiotensin receptor blockers and cerebral protection in stroke. J Hypertens Suppl. 2006;24(1):S115–21.

Article  PubMed  Google Scholar 

Saavedra JM. Angiotensin receptor blockers are not just for hypertension anymore. Physiology (Bethesda). 2021;36(3):160–73.

CAS  PubMed  Google Scholar 

Baron DH, et al. Renin Angiotensin System as a potential treatment target for traumatic brain injury: a systematic review and meta-analysis. J Neurotrauma. 2022;39(7–8):473–86.

Article  PubMed  Google Scholar 

Wright JW, Kawas LH, Harding JW. A role for the brain RAS in Alzheimer’s and Parkinson’s diseases. Front Endocrinol (Lausanne). 2013;4:158.

Article  PubMed  Google Scholar 

Timaru-Kast R, et al. Delayed inhibition of angiotensin II receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma*. Crit Care Med. 2012;40(3):935–44.

Article  CAS  PubMed  Google Scholar 

Villapol S, et al. Candesartan, an angiotensin II AT(1)-receptor blocker and PPAR-gamma agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology. 2012;37(13):2817–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sparks MA, et al. Classical Renin-Angiotensin system in kidney physiology. Compr Physiol. 2014;4(3):1201–28.

Article  PubMed  PubMed Central  Google Scholar 

Carney EF. Hypertension: New non-RAS peptide modulates the vasoregulatory effects of angiotensin II. Nat Rev Nephrol. 2015;11(6):317.

Article  PubMed  Google Scholar 

Chopra S, Baby C, Jacob JJ. Neuro-endocrine regulation of blood pressure. Indian J Endocrinol Metab. 2011;15(Suppl 4):S281–8.

PubMed  PubMed Central  Google Scholar 

Lin S, et al. Role of the ACE2Ang(17)Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review). Mol Med Rep. 2017;16(4):4403–12.

Article  CAS  PubMed  Google Scholar 

Padda RS, et al. Angiotensin-(1–7): a novel peptide to treat hypertension and nephropathy in diabetes? J Diabetes Metab. 2015;6(10).

Xu P, Sriramula S, Lazartigues E. ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good. Am J Physiol Regul Integr Comp Physiol. 2011;300(4):R804–17.

Article  CAS  PubMed  Google Scholar 

Gebre AK, et al. Targeting renin-angiotensin system against Alzheimer’s disease. Front Pharmacol. 2018;9:440.

Article  PubMed  PubMed Central  Google Scholar 

Xu J, et al. The ACE2/angiotensin-(1–7)/mas receptor axis: pleiotropic roles in cancer. Front Physiol. 2017;8:276.

Article  PubMed  PubMed Central  Google Scholar 

Paul M, Poyan Mehr A, Kreutz R. Physiology of local renin-angiotensin systems. Physiol Rev. 2006;86(3):747–803.

Article  CAS  PubMed  Google Scholar 

Bader M. Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy. Annu Rev Pharmacol Toxicol. 2010;50:439–65.

Article  CAS  PubMed  Google Scholar 

Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. Am J Cardiol. 2002;89(2A):3A-9A; discussion 10A.

Article  CAS  PubMed  Google Scholar 

Halbach O, von Bohlen und Albrecht D. The CNS renin-angiotensin system. Cell Tissue Res. 2006;326(2):599–616.

Article  Google Scholar 

Vadhan JD, Speth RC. The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI). Pharmacol Ther. 2021;218:107684.

Article  CAS  PubMed  Google Scholar 

Lenkei Z, et al. Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review. Front Neuroendocrinol. 1997;18(4):383–439.

Article  CAS  PubMed  Google Scholar 

Zhuo J, et al. Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors. J Hypertens. 1998;16(12 Pt 2):2027–37.

Article  CAS  PubMed  Google Scholar 

Sernia C. Location and secretion of brain angiotensinogen. Regul Pept. 1995;57(1):1–18.

Article  CAS  PubMed  Google Scholar 

Stornetta RL, et al. Astrocytes synthesize angiotensinogen in brain. Science. 1988;242(4884):1444–6.

Article  CAS  PubMed  Google Scholar 

Lippoldt A, et al. Cellular localization of angiotensin type 1 receptor and angiotensinogen mRNAs in the subfornical organ of the rat brain. Neurosci Lett. 1993;150(2):153–8.

Article  CAS  PubMed  Google Scholar 

Imboden H, et al. Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia. Regul Pept. 2009;154(1–3):23–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patil J, et al. Intraneuronal angiotensinergic system in rat and human dorsal root ganglia. Regul Pept. 2010;162(1–3):90–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wright JW, Harding JW. Brain renin-angiotensin–a new look at an old system. Prog Neurobiol. 2011;95(1):49–67.

Article  CAS  PubMed  Google Scholar 

Moffett RB, Bumpus FM, Husain A. Cellular organization of the brain renin-angiotensin system. Life Sci. 1987;41(16):1867–79.

Article  CAS  PubMed  Google Scholar 

Lavoie JL, et al. Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. Hypertension. 2004;43(5):1116–9.

Article  CAS  PubMed