Burns can be considered a global health problem, which could result in trauma and devitalization of tissues or organs leading to morbidity and mortality.1 As per the World Health Organization (WHO) burns are estimated to cause 180,000 deaths annually. Worldwide, around 11 million burn victims in 2004, needed medical treatment.2 Every year, more than 100,000 people in India suffer mild to severe burns.3 Wound healing is a synchronized mechanism that integrates multiple phases like homeostasis, the Inflammatory phase,4 the proliferative phase,5 and the remodeling phase.6

Ayurveda and Siddha, the most ancient traditional systems of medicine, are explored once again. Future medical systems are also being connected, as natural remedies are taken from mother nature and put together with cutting-edge technology to create a readily available treatment. Plant-based medications despite being around for 5000 years have not been exploited to their true potential until recent years, in developing countries approximately 70–90% population is shifting towards the ancient remedies constituting plant extracts to a major proportion.7

One-third of medications out of 1-3% representing medication for wounds on the skin in the western pharmacopeia are plant-derived.8 Several studies have proved that phytochemicals from plants act through multiple mechanisms leading to the healing and formation of new tissues in the affected area.9

Saponins are glycosidic secondary metabolites present in plant species but also in certain animal sources such as marine crustaceans.10 The role of triterpenoid saponins in wound healing has been thoroughly investigated through various studies. Studies by Kimura et al. with Asiaticoside11 and Madecosside,12 a triterpenoid saponin obtained from Centella asiatica (Umbelliferae), demonstrated its anti-inflammatory effect in rat scald models. The antioxidant and metalloprotease activity of Bacoside A extracted from Bacopa monnieri showed potential in tissue remodeling after burn injury.13 These results concluded the significance of triterpenoid saponins in wound healing caused by burn injury via inhibiting apoptosis14 and ROS-scavenging activity.13

Many phytochemicals that have the potential for wound-healing activity have been discovered and employed in the modern market. Momordica cymbalaria (synonyms; Momordica tuberosa Roxb. Cogn., or Luffa tuberose Roxb.) is a member of the Cucurbitaceae family. Different extract of the crude drug is said to possess anti-diabetic, hypoglycemic,15 anti-diarrheal activity,16 anti-cancer17 and anti-microbial activity,18 anti-ovulatory and abortifacient potential,19 hepatoprotective and antioxidant activity.20

Since the tissue engineering era, scaffold, 3D structures that resemble the extracellular matrix of living tissue have been assessed for different functions including wound healing and regeneration aspects.21 The properties to be considered during the employment of the scaffold in wound healing is a suitable mechanical and physical characteristic and a strong physiological foundation that promotes cell adhesion, proliferation, and/ or differentiation, They must have a degradation profile that corresponds to the time needed for wound healing and be both biocompatible and biodegradable. High porosity, a high surface area to volume ratio, an interconnected architecture, and the flexibility to conform to the contour of the wound.22

The current study was conducted to demonstrate the methanolic effect of MC and the saponins isolated from methanolic extract on burn wound healing and also its antioxidant properties. The study also compares with the scaffold23 (commercial bio-engineered product).