Available online 29 May 2023
Author links open overlay panel, , , SummaryCannabidiol (CBD) is one of the most important components of the Cannabis sativa plant with delta9-tetrahydrocannabinol (THC). CBD is used both for medical and recreational purposes. It can be of pharmaceutical grade (Epidyolex®), and also self-service purchased in pharmacy, CBD shops and on the internet (non-pharmaceutical). CBD is almost as widespread as it is poorly understood from a pharmacological point of view and particularly in terms of drug interactions. Drug-drug interactions could lead to clinical complications, and we here gather data currently available on pharmacokinetics (PK) drug-drug interactions with CBD through a narrative review. This review shows that several PK drug-drug interactions exist with different class of medications and aims to help clinicians to better know about CBD for their practice as this product is increasingly used.
AbbreviationsANSMAgence nationale de sécurité du médicament et des produits de santé
Cmaxmaximal concentration
SmPCsummary of product characteristics
THCdelta9-tetrahydrocannabinol
Tmaxmaximal time to reach Cmax
UGTuridine diphospho-glucuronosyltransferase
KeywordsCannabidiol
Drug-drug interactions
Pharmacokinetics
Pharmacology
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