Godswill James Udom, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University Oye-Ekiti, PMB 373, Oye-Ekiti, NigeriaFollow
Uduak Peter Ise, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Bingham University, Karu, Nigeria
Omoirri Moses Aziakpono, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Federal University Oye-Ekiti, PMB 373, Oye-Ekiti, Nigeria
Ayodeji Aturamu, Department of Human Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
Mba Ogbonnaya, Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Akwa, Nigeria
Israel Kevin Umana, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Elele, Nigeria
Jude Efiom Okokon, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Nigeria

Introduction: Dr Iguedo Goko Cleanser® is a herbal formulation (HF) widely marketed in southern Nigeria and purported to be very efficacious for the management of various diseases including giardiasis, toilet infections, hypertension, diabetes, ulcer, impotence, low libido, low sperm count amongst others. Medicinal plants reportedly produce an array of adverse reactions capable of inducing harmful conditions, including death. Aim: This study evaluated the subchronic toxicity concern of HF on testicular function and gonadal histoarchitecture in Wistar rats. Methods: Thirty Wistar rats of both sexes were randomly divided into six groups (5/group) and were orally administered HF for 60 days. The control groups received 5 mL/kg of distilled water; the treatment groups were administered 476.24 and 158.75 mg/kg body weight of HF each for both male and female rats. Using standard procedures, semen analysis was done for all male rats. Animals were anaesthetised and sacrificed on the 62nd day; the gonads were eviscerated, weighed and fixed in 10% buffered formalin for histopathological examinations. Results: Significant (p

Udom, Godswill James; Ise, Uduak Peter; Aziakpono, Omoirri Moses; Aturamu, Ayodeji; Ogbonnaya, Mba; Umana, Israel Kevin; and Okokon, Jude Efiom (2023) "Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats," BioMedicine: Vol. 13 : Iss. 2 , Article 5.
DOI: 10.37796/2211-8039.1404