The design of effective vaccines against the SARS-CoV-2, induces an immune response developing high-affinity antibodies or effector T cells, prevents its severe forms and associated mortality, and offers a promising action to control the COVID-19 pandemic. Several vaccines against COVID-19 are already available and recommended in global immunization programs for the entire population over 5 years of age.1 Vaccination is especially important in vulnerable cohorts, particularly those considered immunocompromised which include a subset of patients with IBD using biologic agents, small molecules, immunomodulators, and/or corticosteroids. Previous studies have shown that immunosuppressive drugs in IBD patients may reduce the effectiveness of some vaccines and therefore the vaccination protocol e.g. hepatitis B or influenza may be accelerated or the dose may be increased in these patients to adjust to this situation.2 Recently, a prospective observational study included in the ENEIDA registry (53,682 patients from 73 centers) reviewed infection rate and severity of infection due to COVID-19 in IBD patients and the results were compared with data of the general population in Spain. This study demonstrated that IBD did not worsen COVID-19 prognosis, even when immunosuppressants and biological drugs were used and age and comorbidity were the prognostic factors for more severe COVID-19 infection in IBD patients.3 At present, international experts recommend the vaccination of IBD patients at the earliest opportunity possible, without delay due to immunosuppressive drugs, and according to national guidelines.4

In Spain, the COVID-19 vaccination campaign started in December 2020 and in February 2021 was extended to the general population after targeting priority groups. The goal of the global vaccination strategy against COVID-19 remains to achieve immunization of up to 90 percent of the population. The vaccines used (4 vaccines approved by European Medicines Agency (EMA): BNT162b2 (Pfizer/BioNTech, US), mRNA-1273 (Moderna, Cambridge, US), AZD1222 (AstraZeneca, UK), and Ad26.COV2-S (Janssen Pharmaceutical Companies of Johnson & Johnson, US) and the time at which the population can be vaccinated depends on their age and associated diseases. In September 2021, an additional dose of vaccine was approved in patients with immunosuppression including IBD patients on biologic agents.1 This study aimed to evaluate the vaccination rate and additional dose willingness in this group of-at risk patients.