To compare visual performance and quality of life (QoL) following bilateral implantation of a new nondiffractive extended depth-of-focus (EDOF) intraocular lens (IOL) and a trifocal IOL.

Department of Ophthalmology, Baskent University Faculty of Medicine, Ankara, Turkey.

Prospective comparative interventional case series.

104 eyes of 52 patients with cataract, bilaterally implanted with a nondiffractive EDOF IOL or a trifocal IOL, were included. Outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), distance corrected intermediate visual acuity and distance corrected near visual acuity, defocus curves, QoL (Visual Function Index 14), quality of vision (Quality of Vision [QoV] index), contrast sensitivity (Pelli-Robson chart), and binocular reading speed.

Twenty-six patients were included in each group. The UDVA and CDVA were better in the EDOF group (0.05 ± 0.04 and 0.01 ± 0.04) than the trifocal group (0.13 ± 0.06 and 0.11 ± 0.07) (P = .02 and .01). Defocus curves showed that visual acuity was better with the EDOF IOL for vergences at 0.00, −0.50, and −1.00 and better with the trifocal IOL for vergences at −2.50, −3.00, −3.50, and −4.00. Contrast sensitivity scores were similar with both IOLs (P = .12). The overall mean QoL scores were lower in the EDOF group, indicating a better QoL (P = .04). The QoV was better in the EDOF group with significantly less glare, halos, and blurry vision (P < .01).

The EDOF IOL performed better at distance, and the trifocal IOL performed better at near. Overall QoL and quality of vision were better with the EDOF IOL.