A scoping review was conducted to explore the characteristics, barriers, and enablers of community engagement in place-based approaches to improving health outcomes in a designated area of poor health and disadvantage. The Joanna Briggs Institute methodology for scoping reviews was used. Forty articles met the inclusion criteria of which 31 were conducted in the United Kingdom, United States, Canada, or Australia, and 70% used qualitative methods. The health initiatives were delivered in multiple settings including neighbourhoods, towns, and regions and with a range of population groups including Indigenous and migrant communities. Trust, power, and cultural considerations were the most significant barriers and enablers to community participation in place-based approaches. Developing trust is key to success in community-led, place-based initiatives.