Introduction: To analyze the Choroidal Vascularity Index (CVI) versus Choroidal Thickness (CT) as biomarkers in acute Central Serous Chorioretinopathy (CSCR). Methods: In this multicenter retrospective, cross-sectional, non-interventional study carried out at Puerta de Hierro-Majadahonda University Hospital, Madrid, Spain; Jules Gonin Lausanne, Switzerland and Pittsburg University, USA. 40 eyes from 40 patients with acute CSCR, 40 eyes from 40 patients with keratoconus (KC) and 40 eyes from 40 healthy patients were included. The variables analyzed were age, CT, CVI, and the presence of neurosensory retinal detachment. CT and the CVI were obtained from a 12 mm horizontal single-line b-scan (Triton SS-OCT, Topcon Co, Japan). Blinded measurements of the subfoveal CT were performed manually by two independent investigators. The images of the choroid were automatically binarized using a validated algorithm and a percentage of vascularity was calculated. Results: There were no significant differences in age between the three groups (ANOVA p=0.092). There were statistically significant differences in CT and the CVI (ANOVA p

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