1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

2   Department of Genetic Oncology, Division of Hereditary Tumors, Osaka International Cancer Institute, Osaka, Japan

,

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

3   Department of Practical Gastrointestinal Endoscopy, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

,

Hiroko Nakahira

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

4   Department of Gastroenterology, Japan Community Health Care Organization Hoshigaoka Medical Center, Osaka, Japan

,

Yusaku Shimamoto

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

5   Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan

,

Hirohisa Sakurai

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

6   Department of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan

,

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Akira Maekawa

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Sachiko Yamamoto

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Koji Higashino

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Fumie Fujisawa

2   Department of Genetic Oncology, Division of Hereditary Tumors, Osaka International Cancer Institute, Osaka, Japan

,

Yasumasa Ezoe

7   Ishikawa Gastroenterological Medical Clinic, Osaka, Japan

,

Hideki Ishikawa

7   Ishikawa Gastroenterological Medical Clinic, Osaka, Japan

8   Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Michihiro Mutoh

8   Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

,

Masanori Nojima

9   Center for Translational Research, The Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan

,

Ryu Ishihara

1   Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan

Trial Registration: UMIN Japan Registration number (trial ID): UMIN000022525 Type of study: Prospective cohort study