aTemerty Faculty of Medicine, Department of Anesthesiology and Pain Medicine, University of Toronto

bSchulich Heart Program, Sunnybrook Research Institute, Department of Anesthesia, Sunnybrook Health Sciences Centre

cInstitute of Clinical Evaluative Sciences, Toronto

dDepartment of Medicine, Schulich School of Medicine & Dentistry

eWestern Institute for Neuroscience, Western University, London, Ontario, Canada

Correspondence to Angela Jerath, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada. E-mail: [email protected]