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Article / Publication Details
Abstract
Aims: To investigate the socio-demographic factors and systemic conditions associated with non-arteritic anterior ischaemic optic neuropathy (NAION).
Methods: This was a nationwide population-based retrospective case-controlled study that recruited 9,261 NAION patients selected from the Taiwan National Health Insurance Research Database. The control group consisted of 9,261 age-, sex-, and index date-matched non-NAION patients recruited from the Taiwan Longitudinal Health Insurance Database, 2000. NAION was designated in the database by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) as “code 377.41: ischaemic optic neuropathy without ICD-9-CM code 446.5: giant cell arteritis”. Associated socio-demographic factors and systemic medical conditions were analysed using the McNemar’s test, and continuous variables were analysed using the paired t-test. The odds ratio (OR) and adjusted OR of developing NAION were compared using univariate logistic regression and multivariable logistic regression analyses, respectively.
Results: Patients with systemic conditions such as diabetes mellitus, hypertension, hyperlipidaemia, chronic kidney disease, and hypotension were more likely to develop NAION than controls (adjusted OR=1.81, 95% CI=1.67–1.97, p
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Article / Publication Details
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