Chronological Changes in Mucosal Deformity by Endoscopic Suturing after Gastric Endoscopic Submucosal Dissection: A Multicenter Retrospective Analysis

Higuchi K.a· Goto O.a· Takahashi A.b· Akimoto T.a,c· Habu T.a· Ishikawa Y.a· Kirita K.a· Koizumi E.a· Noda H.a· Onda T.a· Omori J.Akimoto N.Kaise M.Yahagi N.Oyama T.b· Iwakiri K.a

Author affiliations

aDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan
bDepartment of Endoscopy, Saku Central Hospital Advanced Care Center, Saku, Japan
cDivision of Research and Department for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan

Log in to MyKarger to check if you already have access to this content.

Buy FullText & PDF Unlimited re-access via MyKarger Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Access via DeepDyve Unlimited fulltext viewing Of this article Organize, annotate And mark up articles Printing And downloading restrictions apply

Select

Subscribe Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use read more

Subcription rates

Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview

Abstract of Research Article

Received: June 01, 2022
Accepted: September 20, 2022
Published online: December 07, 2022

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Abstract

Introduction: Endoscopic suturing of a mucosal defect is expected to prevent postoperative bleeding after endoscopic submucosal dissection (ESD). Endoscopic suturing causes mucosal deformity, which may interfere with endoscopic surveillance thereafter. We retrospectively investigated long-term chronological changes in mucosal suturing by endoscopic suturing. Methods: Forty-three patients who underwent endoscopic hand suturing (EHS) after gastric ESD at three institutions were enrolled. First, our hypothesis that the suturing sites healed via inflammation, disappearance of mucosal inversion, and flattening was validated. Subsequently, the duration required to reach each healing step was evaluated. Results: A total of 137 follow-up endoscopies were assessed, in which all cases showed the hypothesized chronological course on the suturing sites. The 95th percentiles of the duration when showing the disappearance of the inflammatory change and the inverted change were 63 days and 15.5 months after the procedure, respectively. Discussion/Conclusion: The data show that the mucosal deformity induced by EHS disappeared within 16 months. Endoscopic suturing is thus considered to have a negligible effect on endoscopic surveillance following the procedure.

© 2022 S. Karger AG, Basel

References Park YM, Cho E, Kang HY, Kim JM. The effectiveness and safety of endoscopic submucosal dissection compared with endoscopic mucosal resection for early gastric cancer: a systematic review and metaanalysis. Surg Endosc. 2011 Aug;25(8):2666–77. Oyama T, Yahagi N, Ponchon T, Kiesslich T, Berr F. How to establish endoscopic submucosal dissection in Western countries. World J Gastroenterol. 2015 Oct 28;21(40):11209–20. Isomoto H, Shikuwa S, Yamaguchi N, Fukuda E, Ikeda K, Nishiyama H, et al. Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study. Gut. 2009 Mar;58(3):331–6. Yano T, Tanabe S, Ishido K, Suzuki M, Kawanishi N, Yamane S, et al. Different clinical characteristics associated with acute bleeding and delayed bleeding after endoscopic submucosal dissection in patients with early gastric cancer. Surg Endosc. 2017 Nov;31(11):4542–50. Suzuki H, Takizawa K, Hirasawa T, Takeuchi Y, Ishido K, Hoteya S, et al. Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: ‘real-world evidence’ in Japan. Dig Endosc. 2019 Jan;31(1):30–9. Goto O, Fujishiro M, Oda I, Kakushima N, Yamamoto Y, Tsuji Y, et al. A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding. Dig Dis Sci. 2012 Feb;57(2):435–9. Sato C, Hirasawa K, Koh R, Ikeda R, Fukuchi T, Kobayashi R, et al. Postoperative bleeding in patients on antithrombotic therapy after gastric endoscopic submucosal dissection. World J Gastroenterol. 2017 Aug 14;23(30):5557–66. Azumi M, Takeuchi M, Koseki Y, Kumagai M, Kobayashi Y, Takatsuna M, et al. The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection. Gastric Cancer. 2019 May;22(3):567–75. Kataoka Y, Tsuji Y, Hirasawa K, Takimoto K, Wada T, Mochizuki S, et al. Endoscopic tissue shielding to prevent bleeding after endoscopic submucosal dissection: a prospective multicenter randomized controlled trial. Endoscopy. 2019 Jul;51(07):619–27. Akimoto T, Goto O, Nishizawa T, Yahagi N. Endoscopic closure after intraluminal surgery. Dig Endosc. 2017 Jul;29(5):547–58. Kantsevoy SV, Bitner M, Mitrakov AA, Thuluvath PJ. Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos). Gastrointest Endosc. 2014 Mar;79(3):503–7. Goto O, Sasaki M, Akimoto T, Ochiai Y, Kiguchi Y, Mitsunaga Y, et al. Endoscopic hand-suturing for defect closure after gastric endoscopic submucosal dissection: a pilot study in animals and in humans. Endoscopy. 2017 Aug;49(08):792–7. Goto O, Sasaki M, Ishii H, Horii J, Uraoka T, Takeuchi H, et al. A new endoscopic closure method for gastric mucosal defects: feasibility of endoscopic hand suturing in an ex vivo porcine model (with video). Endosc Int Open. 2014 Jun;02(02):E111–6. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2014 (ver. 4). Gastric Cancer. 2017 Jan;20(1):1–19. Furuhata T, Kaise M, Hoteya S, Iizuka T, Yamada A, Nomura K, et al. Postoperative bleeding after gastric endoscopic submucosal dissection in patients receiving antithrombotic therapy. Gastric Cancer. 2017 Jan;20(1):207–14. Higuchi K, Goto O, Koizumi E, Kirita K, Noda H, Akimoto T, et al. Usefulness of the flexible traction method in gastric endoscopic submucosal dissection: an in-vivo animal study. Surg Endosc. 2020 Dec;34(12):5632–9. Goto O, Oyama T, Ono H, Takahashi A, Fujishiro M, Saito Y, et al. Endoscopic hand-suturing is feasible, safe, and may reduce bleeding risk after gastric endoscopic submucosal dissection: a multicenter pilot study (with video). Gastrointest Endosc. 2020 May;91(5):1195–202. Akimoto T, Goto O, Sasaki M, Mizutani M, Tsutsumi K, Kiguchi Y, et al. Endoscopic suturing promotes healing of mucosal defects after gastric endoscopic submucosal dissection: endoscopic and histologic analyses in in vivo porcine models (with video). Gastrointest Endosc. 2020 May;91(5):1172–82. Kakushima N, Fujishiro M, Kodashima S, Kobayashi K, Tateishi A, Iguchi M, et al. Histopathologic characteristics of gastric ulcers created by endoscopic submucosal dissection. Endoscopy. 2006 Apr;38(4):412–5. Kim JL, Kim SG, Lee A, Choi J, Chung H, Cho SJ. Long-term natural history after endoscopic resection for gastric dysplasia. Surg Endosc. 2021 Sep;35(9):5247–55. Nasu J, Doi T, Endo H, Nishina T, Hirasaki S, Hyodo I. Characteristics of metachronous multiple early gastric cancers after endoscopic mucosal resection. Endoscopy. 2005 Oct;37(10):990–3. Yoon SB, Park JM, Lim CH, Kim JS, Cho YK, Lee BI, et al. Incidence of gastric cancer after endoscopic resection of gastric adenoma. Gastrointest Endosc. 2016 Jun;83(6):1176–83. Moon HS, Yun GY, Kim JS, Eun HS, Kang SH, Sung JK, et al. Risk factors for metachronous gastric carcinoma development after endoscopic resection of gastric dysplasia: retrospective, single-center study. World J Gastroenterol. 2017 Jun 28;23(24):4407–15. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2018 (5th edition). Gastric Cancer. 2021 Jan;24(1):1–21. Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, et al. A scoring system to stratify curability after endoscopic submucosal dissection for early gastric cancer: “eCura system”. Am J Gastroenterol. 2017 Jun;112(6):874–81. Abe S, Oda I, Mori G, Nonaka S, Suzuki H, Yoshianaga S. Complete endoscopic closure of a large gastric defect with endoloop and endoclips after complex endoscopic submucosal dissection. Endoscopy. 2015;47(S 01):E374–5. Ego M, Abe S, Nonaka S, Suzuki H, Yoshinaga S, Oda I, et al. Endoscopic closure utilizing endoloop and endoclips after gastric endoscopic submucosal dissection for patients on antithrombotic therapy. Dig Dis Sci. 2021 Jul;66(7):2336–44. Goda Y, Kobara H, Kobayashi N, Nishiyama N, Fujihara S, Tada N, et al. Long-term outcomes of over-the-scope clip for refractory gastrointestinal diseases. Minim Invasive Ther Allied Technol. 2022 Apr;31(4):628–34. Mori H, Kobara H, Fujihara S, Nishiyama N, Rafiq K, Oryu M, et al. Feasibility of pure EFTR using an innovative new endoscopic suturing device: the double-arm-bar suturing system (with video). Surg Endosc. 2014 Feb;28(2):683–90. Article / Publication Details

First-Page Preview

Abstract of Research Article

Received: June 01, 2022
Accepted: September 20, 2022
Published online: December 07, 2022

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: https://www.karger.com/DIG

Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

留言 (0)

沒有登入
gif