Antibiotics, Vol. 11, Pages 1727: Antifungal Activity of Essential Oil and Plant-Derived Natural Compounds against Aspergillus flavus

Ageratum conyzoidesβ-Caryophyllene; germacrene-D; dimetoxy ageratocromeneWheat; corn; soybean80.8% inhibition at 1 μL/mL (vapor) in wheat grain (12 months); 79.5% and 100% inhibition in corn and soybeans, respectively, with 5 μL EO (disk diffusion assay, 5 days)93.7% reduction with 50 μL in 60 g corn (direct contact) (10 days); >75% reduction with 50 μL in 60 g in soybeans (direct contact) (10 days)[16,17]Ajowan (Trachyspermum ammi L.)p-Cymene; thymolWheat; chickpea46.2% and 65.2% inhibition at 0.8 μL/mL (vapor) in wheat and chickpea, respectively (12 months)100% inhibition at 0.8 μL/mL (vapor) in wheat and chickpea (12 months)[18]Anise (Pimpinella anisum L.)AnetholCorn; wheatMIC: 1000–3000 μg/g (dependent on aw) in corn (11 days); 100% inhibition at 1% (v/w) in wheat (14 days)100% inhibition at 1000 → 3000 μg/g (dependent on aw) in corn (11 days); 100% inhibition at 1% (v/w) in wheat (8 weeks)[6,19]Boldo (Pëumus boldus Mol)α-Terpinolene; α-terperpine; p-cimeneCornMIC: 500–2000 μg/g (dependent on aw) (11 days)100% inhibition at 500–2000 μg/g (dependent on aw) (11 days)[6]Boswellia carterii BirdwPhenylethyl alcohol; benzyl acetatePepper fruits (Piper nigrum L.)65.4% inhibition at 1.75 μL/mL (vapor) (6 months)No record[20]Boswellia serrata3-Carene; β-ocimeneCornNo record95.6% inhibition at 10 μL/g (10 days)[21]Cananga odorataβ-CaryophylleneChickpea77.4% inhibition at 2 μL/mL (vapor) (6 months)No record[22]Caraway (Carum carvi)Limonene; carvoneBread; polenta90% inhibition at 636.47 μL/L (vapor) in bread (14 days)100% inhibition in bread requires > 500 μL/L of EO (vapor) (14 days); 100% inhibition at 4.5 μg/g in polenta (14 days)[23,24]Carum copticump-Cymene; γ-terpinene; thymolCherry tomato58.0% inhibition at 100 μL/mL (vapor) (30 days)No record[25]Chenopodium ambrosioides Linn.α-Terpinene; p-cymene; AscaridolePigeon pea100% inhibition at 0.29 μL/mL (vapor) (6 months)No record[26]Cicuta virosa L. var. latisecta Celakp-Cymene; γ-terpinene; cuminaldehydeCherry tomato89.9% inhibition at 200 μg/mL (vapor) (9 days)No record[27]Cinnamomum glaucescens1,8-Cineole; 2-propenoic acidChickpea71.1% inhibition at 4.5 μL/mL (vapor) (12 months)No record[28]Cinnamon (Cinnamomum verum)Cinnamaldehyde; eugenolMaize extract medium; bread90% inhibition at 820 → 1000 mg/L (depending on temperature and water activity) in maize extract medium (12 days); 90% inhibition at 558.44 μL/L (vapor) in bread (14 days)500–1000 mg/L (depending on temperature and water activity) in maize extract medium (12 days); 100% inhibition at 500 μL/L (vapor) in bread (14 days)[23,29]Cinnamon (Cinnamomum zeglanicum)Cinnamaldehyde; eugenol; phenol, 2-methoxy-4-(2-propenyl)phenolPistachio; finger millet (Eleusine coracana); wheat60–83% inhibition at 0.5 μL/mL (vapor) in finger millet (up to 6 months); 100% inhibition at 2% (v/w) in wheat (14 days) 100% inhibition with 25 mL of 9% (vol/vol) EO solution in 500 g pistachio (3 months); 100% inhibition at 2% (v/w) in wheat (8 weeks)[19,30,31]Citrus reticulataLimonene; geranial; neralTuberous roots of Asparagus racemosus68.6% inhibition at 500 ppm (v/v) (12 months)61.76% inhibition at 500 ppm (v/v) (12 months)[32]Clausena pentaphyllaSabinene; α-terpinolene; methyl eugenolPigeon pea seed100% inhibition at 0.29 μL/mL (vapor) (6 months)No record[33]Clove (Caryophyllus aromaticus)eugenolPistachioNo record100% inhibition with 25 mL of 9% (vol/vol) EO in 500 g pistachio (3 months).[30]Clove (Syzygium aromaticum L.)Benzenemethanol; eugenol; eugeyl acetate; β-caryophylleneCorn; Iranian white cheese; bread; tomato paste100% inhibition at 500–3000 μg/g (dependent on water activity) in corn (11 days); 100% inhibition at 10 μL/L (vapor) in corn (5 days); 100% inhibition at 150 ppm in Iranian white cheese (up to 40 days); 90% inhibition at 674.49 μL/L (vapor) in bread (14 days); 48% inhibition at 500 ppm in tomato paste (2 months)100% inhibition at 1000–2000 μg/g (dependent on water activity) in corn (11 days); 100% inhibition at 10 μL/L (vapor) in corn (5 days); 100% inhibition at 50–150 ppm in Iranian white cheese (up to 40 days); 100% inhibition at 500 μL/L (vapor) in bread (14 days);[6,23,34,35,36]Coleus aromaticusThymol; γ-terpinene; p-cymeneWheat87.37% inhibition at 0.1 μL/mL (vapor) (12 months); No record[16]Commiphora myrrhaα–Elemene; curzerene; furanoeudesma-1,3-dieneChickpea55.4% inhibition at 3 μL/mL (vapor) (6 months)No record[22]Coriander (Coriandrum sativum L.)Linalool; λ-terpineneChickpea65.5% inhibition at 2.5 μL/mL (vapor) (6 months)No record[22]Cymbopogon citratusGeranial; neral; myrceneTuberous root of Asparagus racemosus78.4% inhibition at 500 ppm (v/v) (12 months)100% inhibition at 500 ppm (v/v) on (12 months)[32]Dill (Anethum graveolens L.)Carvone; limonene; apiolCherry tomato88.9% inhibition at 120 μg/mL (vapor) (9 days)No record[37]Fennel (Foeniculum vulgare)Estragole; anetholeTobacco leave51.20–55.35% inhibition at 1.25 μL/mL (vapor) (6 months);100% inhibition at 1.25 μL/mL (vapor) (6 months);[38]Fingerroot (Boesenbergia rotunda)Nerol; L-camphorIn-shell peanutNo record98.3% and 18.0% inhibition at 16% (v/v, in mineral oil) when applied via direct exposure and vapor exposure, respectively (10 days).[39]Hedychium spicatum1,8-CineoleChickpea72.0% inhibition at 2.5 μL/mL (vapor)No record[22]Holy basil (Ocimum sanctum)Eugenol; β-caryophylleneApocynaceae (Rauvolfia serpentina L., medicinal plant)74.0% inhibition at 1 μL/mL (vapor) (6 months)No record[40]Hyptis suaveolensβ -Caryophyllene; caryophyllene oxide; sabineneWheat83.3% inhibition at 1.2 μL/mL (vapor) (12 months)No record[16]Juniper (Juniperus communis L.)α-PinenePolentaNo record100% inhibition at 50 μg/g (14 days)[24]Lemongrass (Cymbopogon citrati [DC] Stapf.)Neral; geranialBread90% inhibition at 134.12 μL/L (vapor) (14 days)100% inhibition at 125 μL/L (vapor) (14 days)[23]Lippia albaMyrcene; neral; geranialGreen gram seed92.5% inhibition at 80 μL/0.25 L (vapor) (6 months)100% inhibition at 80 μL/0.25 L (vapor) (6 months)[41]Litsea cubebaD-Limonene; (Z)-limonene oxide; (E)-limonene oxideLicorice100% inhibition at 5 μL/g (vapor) (20 days);100% inhibition at 5 μL/g (vapor) (20 days);[42]Marjoram (Origanum majorana L.)Terpinen-4-ol; cis-sabinene hydrate; p-cymeneChickpea67.9% inhibition at 3 μL/mL (vapor) (6 months)No record[22]Mentha spicata L.Carvone; limoneneChickpea52.2% inhibition at 1 μL/mL (vapor) (12 months); 100% inhibition at 1 μL/mL (vapor) (12 months);[43]Michelia albaLinaloolBrown rice100% inhibition at 300 μL/L (vapor) (12 weeks)No record[44]Mint (Mentha viridis)Menthone; carvoneWheat; corn100% inhibition at 200 mL/100 g in corn (21 days); 92% inhibition at 2% (v/w) in wheat (14 days)100% inhibition at 300 mL/100 g in corn (21 days); >99% inhibition at 2% (v/w) in wheat (8 weeks)[19,45]Mountain thyme (Hedeoma multiflora Benth) α-Terpinolene; p-cymene; carvacrolCorn100% inhibition at 500–2000 μg/g (dependent on water activity) (11 days);100% inhibition at 1000 μg/g (11 days);[6]Ocimum basilicum L.Methyl eugenolDry fruits (cashew nut, almond, grapes, chironji, groundnut, date palm, and coconut) 53.8–65.5% inhibition at 1 μg/mL (vapor) (6 months)No record[46]Oregano (Origanum vulgare L.)Carvacrol; linalool; 4-terpineol Maize extract medium; bread; corn; soybean90% inhibition at 820 → 1000 mg/L (depending on temperature and water activity) in maize extract medium (12 days); 90% inhibition at 319.85 μL/L (vapor) in bread (14 days); 100% inhibition with 5 μL EO in corn and soybean (disk diffusion assay, 5 days)100% inhibition at >1000 mg/L in maize extract medium (12 days); 100% inhibition at 125 μL/L (vapor) in bread (14 days); >90% and 88.16% inhibition with 200 μL EO in 60 g corn and soybean, respectively (direct contact) (10 days)[17,23,29]Pine (Pinus pinaster)β-Caryophyllene; β-selineneIn-shell peanutNo record98.1% and 12.9% inhibition at 16% (v/v, in mineral oil) when applied via direct exposure and vapor exposure, respectively (10 days)[39]Poleo (Lippia turbinate var. integrifolia (griseb))Peperitenone oxide; limoneneCorn100% inhibition at 500–2000 μg/g (depending on water active) (11 days) 100% inhibition at 500–2000 μg/g (depending on water active) (11 days) [6]Rosewood (Aniba rosaeodora)LinaloolIn-shell peanutNo record98.5% and 17.2% inhibition at 16% (v/v, in mineral oil) when applied via direct exposure and vapor exposure, respectively (10 days)[39]Rosmarinus officinalis L.α-Pinene; 1, 8-cineole; camphorBlack pepper (Piper nigrum)73.5% inhibition at 1.5 μL/mL (vapor) (6 months);No record[47]Styrax tonkinensisBenzoic acid; 6-phenyl-tetrahydro-naphthalineIn-shell peanutNo record95.8% and 20.2% inhibition at 16% (v/v, in mineral oil) when applied via direct exposure and vapor exposure, respectively (10 days).[39]Summer savory (Satureja hortensis)γ-terpinene; carvacrol; thymolTomato paste59% inhibition at 500 ppm (2 months)No record[36]Thyme (Thymus vulgaris L.)Carvacrol; a-terpinolene; thymol; p-cymene; β-phellandrene; linaloolBread; tomato paste; wheat; brown rice; white rice90% inhibition at 474.2 μL/L (vapor) in bread (14 days); 87% inhibition at 500 ppm in tomato paste (2 months); 100% inhibition at 1% (v/w) in wheat (14 days)100% inhibition at 250 μL/L (vapor) in bread (14 days); 100% inhibition at 1% (v/w) on wheat (8 weeks); 72.7% inhibition at 10 μg/mL (vapor) in brown rice; 18.0% inhibition at 10 μg/mL (vapor) in white rice[19,23,36,48]Thyme (Zataria multiflora)Thymol; carvacrolIranian white cheese89.0% inhibition at 600 ppm (up to 40 days)92.9% inhibition at 600 ppm (up to 40 days)[35]Thymus daenensis CelakThymol; carvacrolPistachioNo record100% inhibition with 25 ml of 9% (vol/vol) EO solution in 500 g pistachio (3 months)[30]Turmeric (Curcuma longa L.)Tumerone; ar-turmerone; β-sesquiphellandrene; zingiberene; cycloisolongifoleneCorn~90% inhibition at 4 μg/mL (5 days)~93% inhibition at 4 μg/mL (5 days)[49]Vatica (Vatica diospyroides Symington)Benzyl acetateCorn100% inhibition at 50 μL/L (vapor) (5 days)100% inhibition at 50 μL/L (vapor) (5 days)[34]Ylang ylang (Cananga odorata)Linalool; benzyl acetate; tetradecane; germacrene DIn-shell peanutNo record96.4% and 25.1% inhibition at 16% (v/v, in mineral oil) when applied via direct exposure and vapor exposure, respectively (10 days).[39]Zanthoxylum alatumLinalool; methyl cinnamateBlack pepper (Piper nigrum)87.6% inhibition at 2.5 μL/mL (vapor) (6 months)No record[50]Zanthoxylum molle RehdLimonene; terpinen-4-ol; 2-undecanoneCherry tomato91.7% inhibition at 0.2 μg/mL (vapor) (9 days)No record[51]Zingiber zerumbetα-Caryophyllene; zerumboneCorn100% inhibition at 200 ppm (15 days)100% inhibition at 100 ppm (direct contact) (15 days)[52]Ziziphora clinopodioidesPulegone; piperitenone; p-menth-3-en-8-olCornNo record99.8% inhibition at 6250 μg/mL (29 days)[53]

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