Galiè N. Humbert M. Vachiery J.L. et al.

[2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension].

Kardiol Pol. 73: 1127-1206Rudski L.G. Gargani L. Armstrong W.F. et al.

Stressing the Cardiopulmonary Vascular System: The Role of Echocardiography.

J Am Soc Echocardiogr. 31: 527-550.e11Harjola V.P. Mebazaa A. Čelutkienė J. et al.

Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology.

Eur J Heart Fail. 18: 226-241Tuder R.M. Archer S.L. Dorfmüller P. et al.

Relevant issues in the pathology and pathobiology of pulmonary hypertension.

J Am Coll Cardiol. 62: D4-D12Ling Y. Johnson M.K. Kiely D.G. et al.

Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.

Am J Respir Crit Care Med. 186: 790-796Cittadini A. Bossone E. Marra A.M. et al.

[Anabolic/catabolic imbalance in chronic heart failure].

Monaldi Arch Chest Dis. 74: 53-56Bossone E. Arcopinto M. Iacoviello M. et al.

Multiple hormonal and metabolic deficiency syndrome in chronic heart failure: rationale, design, and demographic characteristics of the T.O.S.CA. Registry.

Intern Emerg Med. 13: 661-671Merola B. Cittadini A. Colao A. et al.

Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency.

J Clin Endocrinol Metab. 77: 1658-1661Salzano A. Marra A.M. Ferrara F. et al.

Multiple hormone deficiency syndrome in heart failure with preserved ejection fraction.

Int J Cardiol. 225: 1-3Salzano A. De Luca M. Israr M.Z. et al.

Exercise Intolerance in Heart Failure with Preserved Ejection Fraction.

Heart Failure Clin. 17: 397-413Arcopinto M. Bobbio E. Bossone E. et al.

The GH/IGF-1 axis in chronic heart failure.

Endocr Metab Immune Disord Drug Targets. 13: 76-91Arcopinto M. Isgaard J. Marra A.M. et al.

IGF-1 predicts survival in chronic heart failure. Insights from the T.O.S.CA. (Trattamento Ormonale Nello Scompenso CArdiaco) registry.

Int J Cardiol. 176: 1006-1008Salzano A. Cittadini A. Bossone E. et al.

Multiple hormone deficiency syndrome: a novel topic in chronic heart failure.

Future Sci. 4: FSO311Cittadini A. Marra A.M. Arcopinto M. et al.

Growth hormone replacement delays the progression of chronic heart failure combined with growth hormone deficiency: an extension of a randomized controlled single-blind study.

JACC Heart Fail. 1: 325-330Cittadini A. Saldamarco L. Marra A.M. et al.

Growth hormone deficiency in patients with chronic heart failure and beneficial effects of its correction.

J Clin Endocrinol Metab. 94: 3329-3336Iellamo F. Volterrani M. Caminiti G. et al.

Testosterone therapy in women with chronic heart failure: a pilot double-blind, randomized, placebo-controlled study.

J Am Coll Cardiol. 56: 1310-1316Xanthouli P. Theobald V. Benjamin N. et al.

Prognostic impact of hypochromic erythrocytes in patients with pulmonary arterial hypertension.

Respir Res. 22: 288Marra A.M. Arcopinto M. Bossone E. et al.

Pulmonary arterial hypertension-related myopathy: an overview of current data and future perspectives.

Nutr Metab Cardiovasc Dis. 25: 131-139Argiento P. Chesler N. Mulè M. et al.

Exercise stress echocardiography for the study of the pulmonary circulation.

Eur Respir J. 35: 1273-1278Galiè N. Humbert M. Vachiery J.L. et al.

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).

Eur Heart J. 37: 67-119Condliffe R. Kiely D.G. Peacock A.J. et al.

Connective tissue disease-associated pulmonary arterial hypertension in the modern treatment era.

Am J Respir Crit Care Med. 179: 151-157Farber H.W. Miller D.P. Poms A.D. et al.

Five-Year outcomes of patients enrolled in the REVEAL Registry.

Chest. 148: 1043-1054

Imaging the heart in pulmonary hypertension: an update.

Eur Respir Rev. 24: 653-664Amsallem M. Sternbach J.M. Adigopula S. et al.

Addressing the Controversy of Estimating Pulmonary Arterial Pressure by Echocardiography.

J Am Soc Echocardiogr. 29: 93-102Vonk Noordegraaf A. Westerhof B.E. Westerhof N.

The Relationship Between the Right Ventricle and its Load in Pulmonary Hypertension.

J Am Coll Cardiol. 69: 236-243Yamada Y. Okuda S. Kataoka M. et al.

Prognostic value of cardiac magnetic resonance imaging for idiopathic pulmonary arterial hypertension before initiating intravenous prostacyclin therapy.

Circ J. 76: 1737-1743Soon E. Holmes A.M. Treacy C.M. et al.

Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension.

Circulation. 122: 920-927Al-Naamani N. Palevsky H.I. Lederer D.J. et al.

Prognostic Significance of Biomarkers in Pulmonary Arterial Hypertension.

Ann Am Thorac Soc. 13: 25-30Batt J. Ahmed S.S. Correa J. et al.

Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension.

Am J Respir Cell Mol Biol. 50: 74-86Pagan J. Seto T. Pagano M. et al.

Role of the ubiquitin proteasome system in the heart.

Circ Res. 112: 1046-1058Wei Y. Chen K. Whaley-Connell A.T. et al.

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species.

Am J Physiol Regul Integr Comp Physiol. 294: R673-R680Michell B.J. Griffiths J.E. Mitchelhill K.I. et al.

The Akt kinase signals directly to endothelial nitric oxide synthase.

Curr Biol. 9: 845-848Grinnan D. Farr G. Fox A. et al.

The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension.

J Diabetes Res. 2016: 2481659Jin C. Guo J. Qiu X. et al.

IGF-1 induces iNOS expression via the p38 MAPK signal pathway in the anti-apoptotic process in pulmonary artery smooth muscle cells during PAH.

J Recept Signal Transduct Res. 34: 325-331Baird G.L. Archer-Chicko C. Barr R.G. et al.

Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue disease- and congenital heart disease-associated pulmonary arterial hypertension.

Eur Respir J. 51https://doi.org/10.1183/13993003.00467-2018Smith A.M. Bennett R.T. Jones T.H. et al.

Characterization of the vasodilatory action of testosterone in the human pulmonary circulation.

Vasc Health Risk Manag. 4: 1459-1466

Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension.

Eur J Med Res. 14: 433-442Cittadini A. Salzano A. Iacoviello M. et al.

Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the T.O.S.CA. Registry.

Eur J Prev Cardiol. https://doi.org/10.1093/eurjpc/zwab020Jones R.D. English K.M. Pugh P.J. et al.

Pulmonary vasodilatory action of testosterone: evidence of a calcium antagonistic action.

J Cardiovasc Pharmacol. 39: 814-823Arcopinto M. Salzano A. Giallauria F. et al.

Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the T.O.S.CA. GHD Study.

PLoS One. 12: e0170058Salzano A. Arcopinto M. Marra A.M. et al.

Klinefelter syndrome, cardiovascular system, and thromboembolic disease: review of literature and clinical perspectives.

Eur J Endocrinol. 175: R27-R40

The association of heart failure with insulin resistance and the development of type 2 diabetes.

Am J Hypertens. 18: 731-737Doehner W. Frenneaux M. Anker S.D.

Metabolic impairment in heart failure: the myocardial and systemic perspective.

J Am Coll Cardiol. 64: 1388-1400