Epithelial ovarian, tubal, and primary peritoneal cancer affects 1 in 70 women in industrialized countries [1]. It is the eighth most frequent cancer [1] worldwide in terms of incidence and mortality, with 313,959 new cases and 207,252 deaths in 2020 [2]. Furthermore, according to the 2014 classification of the International Federation of Gynecology and Obstetrics (FIGO), 75% of the ovarian cancers are diagnosed at an advanced stage (stage IIIC–IV) [3]. In France [1], according to data from the Saint Paul de Vence conference [4], hyperthermic intraperitoneal chemotherapy (HIPEC) can be proposed for the management of primary epithelial ovarian, tubal, and peritoneal cancers of FIGO III stage that are initially unresectable after 3 or 4 cycles of intravenous (IV) chemotherapy during surgery for maximal interval tumor reduction with an operative tumor residue of less than 10 mm.

Moreover, concerning the question of the approach to HIPEC, various medical teams do not issue preferential recommendations. Laparoscopy, a minimally invasive surgery, can be used in this new model. In gynecological surgery, laparoscopy is the standard approach for benign or malignant pathologies [5], [6], [7], [8], [9] as patients have fewer postoperative infections, and overall postoperative morbidity is reduced [5], [6], [7], [8], [9] with earlier discharge and quicker return to normal activities [5,10,11]. For advanced ovarian cancer, laparoscopy is performed for diagnostic purposes and to predict whether complete surgical resection is possible [12,13]. Recently, laparoscopy has been used for tumor reduction surgery [14,15] without compromising survival in patients with small tumors [16], [17], [18], [19]. The main objective of this study was to describe the establishment of HIPEC in an expert gynecological cancer as well as intra- and postoperative results, in particular the approach, duration, complications, and the time between surgery and chemotherapy. The secondary objective was to compare the conventional laparotomy and laparoscopic approaches for HIPEC.