Limawararut V, Leibovitch I, Sullivan T, Selva D. Periocular squamous cell carcinoma. Clin Exp Ophthalmol. 2007;35:174–85.

PubMed  Google Scholar 

Wang L, Shan Y, Dai X, You N, Shao J, Pan X, et al. Clinicopathological analysis of 5146 eyelid tumours and tumour-like lesions in an eye centre in South China, 2000-2018: a retrospective cohort study. BMJ Open. 2021;11:e041854.

PubMed  PubMed Central  Google Scholar 

Kaliki S, Bothra N, Bejjanki KM, Nayak A, Ramappa G, Mohamed A, et al. Malignant eyelid tumors in India: a study of 536 Asian Indian patients. Ocul Oncol Pathol. 2019;5:210–9.

PubMed  Google Scholar 

Goepfert H, Dichtel WJ, Medina JE, Lindberg RD, Luna MD. Perineural invasion in squamous cell skin carcinoma of the head and neck. Am J Surg. 1984;148:542–7.

CAS  PubMed  Google Scholar 

Gupta A, Veness M, De’Ambrosis B, Selva D, Huilgol SC. Management of squamous cell and basal cell carcinomas of the head and neck with perineural invasion. Australas J Dermatol. 2016;57:3–13.

PubMed  Google Scholar 

Mohs FE, Lathrop TG. Modes of spread of cancer of skin. AMA Arch Derm Syphilol. 1952;66:427–39.

CAS  PubMed  Google Scholar 

Cottel WI. Perineural invasion by squamous-cell carcinoma. J Dermatol Surg Oncol. 1982;8:589–600.

CAS  PubMed  Google Scholar 

Malhotra R, Huilgol SC, Huynh NT, Selva D. The Australian Mohs database: periocular squamous cell carcinoma. Ophthalmology. 2004;111:617–23.

PubMed  Google Scholar 

Donaldson MJ, Sullivan TJ, Whitehead KJ, Williamson RM. Squamous cell carcinoma of the eyelids. Br J Ophthalmol. 2002;86:1161.

CAS  PubMed  PubMed Central  Google Scholar 

Sun MT, Andrew NH, O’Donnell B, McNab A, Huilgol SC, Selva D. Periocular squamous cell carcinoma: TNM staging and recurrence. Ophthalmology. 2015;122:1512–6.

PubMed  Google Scholar 

Faustina M, Diba R, Ahmadi MA, Esmaeli B. Patterns of regional and distant metastasis in patients with eyelid and periocular squamous cell carcinoma. Ophthalmology. 2004;111:1930–2.

PubMed  Google Scholar 

Xie M, Yu J, Li L, Jia R, Song X, Wang Y, et al. Nomogram for preoperative estimation of orbit invasion risk in periocular squamous cell carcinoma. Front Oncol. 2020;10:564.

Nasser QJ, Roth KG, Warneke CL, Yin VT, El Sawy T, Esmaeli B. Impact of AJCC ‘T’ designation on risk of regional lymph node metastasis in patients with squamous carcinoma of the eyelid. Br J Ophthalmol. 2014;98:498–501.

PubMed  Google Scholar 

Soysal HG, Markoç F. Invasive squamous cell carcinoma of the eyelids and periorbital region. Br J Ophthalmol. 2007;91:325–9.

PubMed  Google Scholar 

Xu S, Sagiv O, Rubin ML, Sa H-S, Tetzlaff MT, Nagarajan P, et al. Validation study of the AJCC cancer staging manual, eighth edition, staging system for eyelid and periocular squamous cell carcinoma. JAMA Ophthalmol. 2019;137:537–42.

PubMed  PubMed Central  Google Scholar 

Panizza B, Warren TA, Solares CA, Boyle GM, Lambie D, Brown I. Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment. Head Neck. 2014;36:1611–8.

PubMed  Google Scholar 

Feasel AM, Brown TJ, Bogle MA, Tschen JA, Nelson BR. Perineural invasion of cutaneous malignancies. Dermatol Surg. 2001;27:531–42.

CAS  PubMed  Google Scholar 

Chen-Tsai CP, Colome-Grimmer M, Wagner RF Jr. Correlations among neural cell adhesion molecule, nerve growth factor, and its receptors, TrkA, TrkB, TrkC, and p75, in perineural invasion by basal cell and cutaneous squamous cell carcinomas. Dermatol Surg. 2004;30:1009–16.

PubMed  Google Scholar 

Vural E, Hutcheson J, Korourian S, Kechelava S, Hanna E. Correlation of neural cell adhesion molecules with perineural spread of squamous cell carcinoma of the head and neck. Otolaryngol Head Neck Surg. 2000;122:717–20.

CAS  PubMed  Google Scholar 

Anderson TD, Feldman M, Weber RS, Ziober AF, Ziober BL. Tumor deposition of laminin-5 and the relationship with perineural invasion. Laryngoscope. 2001;111:2140–3.

CAS  PubMed  Google Scholar 

Slater D, Barrett P. Standards and datasets for reporting cancers: dataset for histopathological reporting of primary invasive cutaneous squamous cell carcinoma and regional lymph nodes. The Royal College of Pathologists; 2019. Available from: https://www.rcpath.org/uploads/assets/9c1d8f71-5d3b-4508-8e6200f11e1f4a39/Dataset-for-histopathological-reporting-of-primary-invasive-cutaneous-squamous-cell-carcinoma-and-regional-lymph-nodes.pdf.

Veness MJ, Biankin S. Perineural spread leading to orbital invasion from skin cancer. Australas Radiol. 2000;44:296–302.

CAS  PubMed  Google Scholar 

Liebig C, Ayala G, Wilks JA, Berger DH, Albo D. Perineural invasion in cancer: a review of the literature. Cancer. 2009;115:3379–91.

CAS  PubMed  Google Scholar 

Valenzuela AA, Whitehead KJ, Sullivan TJ. Ocular adnexal pseudo-cyst formation as a characteristic feature of perineural spread in squamous cell carcinoma. Ophthalmic Plast Reconstr Surg. 2006;22:201–5.

PubMed  Google Scholar 

Ampil FL, Hardin JC, Peskind SP, Stucker FJ. Perineural invasion in skin cancer of the head and neck: a review of nine cases. J Oral Maxillofac Surg. 1995;53:34–8.

CAS  PubMed  Google Scholar 

Carter JB, Johnson MM, Chua TL, Karia PS, Schmults CD. Outcomes of primary cutaneous squamous cell carcinoma with perineural invasion: an 11-year cohort study. JAMA Dermatol. 2013;149:35–41.

PubMed  Google Scholar 

Ebenezer GJ, McArthur JC, Thomas D, Murinson B, Hauer P, Polydefkis M, et al. Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies. Brain. 2007;130:2703–14.

PubMed  Google Scholar 

Lee LY, De Paz D, Lin CY, Fan KH, Wang HM, Hsieh CH, et al. Prognostic impact of extratumoral perineural invasion in patients with oral cavity squamous cell carcinoma. Cancer Med. 2019;8:6185–94.

PubMed  PubMed Central  Google Scholar 

Miller ME, Palla B, Chen Q, Elashoff DA, Abemayor E, St John MA, et al. A novel classification system for perineural invasion in noncutaneous head and neck squamous cell carcinoma: histologic subcategories and patient outcomes. Am J Otolaryngol. 2012;33:212–5.

PubMed  Google Scholar 

Sapir E, Tolpadi A, McHugh J, Samuels SE, Elalfy E, Spector M, et al. Skin cancer of the head and neck with gross or microscopic perineural involvement: patterns of failure. Radiother Oncol. 2016;120:81–6.

PubMed  Google Scholar 

Lin C, Tripcony L, Keller J, Poulsen M, Martin J, Jackson J, et al. Perineural infiltration of cutaneous squamous cell carcinoma and basal cell carcinoma without clinical features. Int J Radiat Oncol Biol Phys. 2012;82:334–40.

PubMed  Google Scholar 

Garcia-Serra A, Hinerman RW, Mendenhall WM, Amdur RJ, Morris CG, Williams LS, et al. Carcinoma of the skin with perineural invasion. Head Neck. 2003;25:1027–33.

PubMed  Google Scholar 

Loeffler JS, Larson DA, Clark JR, Weichselbaum RR, Norris CM Jr., Ervin TJ. Treatment of perineural metastasis from squamous carcinoma of the skin with aggressive combination chemotherapy and irradiation. J Surg Oncol. 1985;29:181–3.

CAS  PubMed  Google Scholar 

Han A, Ratner D. What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion? Cancer. 2007;109:1053–9.

PubMed  Google Scholar 

Reule RB, Golda NJ, Wheeland RG. Treatment of cutaneous squamous cell carcinoma with perineural invasion using mohs micrographic surgery: report of two cases and review of the literature. Dermatologic Surg. 2009;35:1559–66.

CAS  Google Scholar 

Panizza B, Solares CA, Redmond M, Parmar P, O’Rourke P. Surgical resection for clinical perineural invasion from cutaneous squamous cell carcinoma of the head and neck. Head Neck. 2012;34:1622–7.

PubMed  Google Scholar 

Campoli M, Brodland DG, Zitelli J. A prospective evaluation of the clinical, histologic, and therapeutic variables associated with incidental perineural invasion in cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2014;70:630–6.

PubMed  Google Scholar 

Conde-Ferreirós A, Corchete LA, Jaka A, Santos-Briz Á, Fuente MJ, Posada R, et al. Patterns of incidental perineural invasion and prognosis in cutaneous squamous cell carcinoma: a multicenter, retrospective cohort study. J Am Acad Dermatol. 2021;84:1708–12.

PubMed  Google Scholar 

Karia PS, Morgan FC, Ruiz ES, Schmults CD. Clinical and incidental perineural invasion of cutaneous squamous cell carcinoma: a systematic review and pooled analysis of outcomes data. JAMA Dermatol. 2017;153:781–8.

PubMed  PubMed Central  Google Scholar 

Ross AS, Whalen FM, Elenitsas R, Xu X, Troxel AB, Schmults CD. Diameter of involved nerves predicts outcomes in cutaneous squamous cell carcinoma with perineural invasion: an investigator-blinded retrospective cohort study. Dermatol Surg. 2009;35:1859–66.

CAS  PubMed  Google Scholar 

Totonchy MB, McNiff JM, Suozzi KC, Leffell DJ, Christensen SR. A histopathologic scoring system for perineural invasion correlates with adverse outcomes in patients with cutaneous squamous cell carcinoma. Dermatol Surg. 2021;47:445–51.

CAS  PubMed  Google Scholar 

Union for International Cancer Control. TNM Classification of malignant tumours. Eighth edition. Oxford: Wiley Blackwell; 2017. Available from: https://www.wiley.com/en-au/TNM+Classification+of+Malignant+Tumours,+8th+Edition-p-9781119263579.

AJCC cancer staging manual. 8th ed. Switzerland: Springer; 2017. Available from: https://link.springer.com/book/9783319406176

Keohane SG, Botting J, Budny PG, Dolan OM, Fife K, Harwood CA, et al. British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma 2020. Br J Dermatol. 2021;184:401–14.

CAS  PubMed  Google Scholar 

Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, et al. European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: part 2. Treatment. Eur J Cancer. 2020;128:83–102.

CAS  PubMed  Google Scholar 

Cancer Council Australia Keratinocyte Cancers Guideline Working Party. Clinical practice guidelines for keratinocyte cancer. Sydney: Cancer Council Australia. Available from: https://wiki.cancer.org.au/australia/Guidelines:Keratinocyte_carcinoma.

National Comprehensive Cancer Network. Squamous Cell Skin Cancer. Version 1. 2022. Available from: https://www.nccn.org/professionals/physician_gls/pdf/squamous.pdf.

Leibovitch I, Huilgol SC, Selva D, Hill D, Richards S, Paver R. Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia II. Perineural invasion. J Am Acad Dermatol. 2005;53:261–6.

PubMed  Google Scholar 

Botha VE, Chow KTK, Salmon PJM, El-Khayat RH, Sun MT, Selva D, et al. Periorbital desmoplastic squamous cell carcinoma. Orbit. 2019;38:240–3.

PubMed  Google Scholar 

Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL. Risk factors for cutaneous squamous cell carcinoma recurrence, metastasis, and disease-specific death: a systematic review and meta-analysis. JAMA Dermatol. 2016;152:419–28.

PubMed  PubMed Central