Malignant myoepithelioma (MM) is a rare aggressive breast tumor. Its management is not standardized, in particular because of the clinical polymorphism.

This tumor is classified under metaplastic carcinoma in the last WHO classification of tumors of the breast of 2012. The myoepithelial carcinoma (malignant myoepithélioma) are characterized by a pure proliferation of myoepithelial cells that merges in phenotype with metaplastic carcinoma and has the propensity for metastasis.

Metaplastic breast carcinoma account for 0.2-5% of all invasive breast cancers and encompasses a group of lesions characterized by differentiation of the neoplastic epithelium into squamous cells and /or mesenchymal looking elements, including spindle, chondroid, osseous and rhabdomyoid cells.

There are no definitive criteria to differentiate spindle cell carcinoma and MM but some data suggest that these lesions display distinct clinical behavior.

In this study we have collected only articles on malignant myoepithelioma. The available literature regarding this disease comprises case reports or case series including few patients.

The aim of our study was to identify, assess and review all relevant series and case reports of Malignant breast myoepithelioma published in the past 40 years.

Our specific objectives were to describe i) Individual and clinical characteristics, and ii) the range of therapeutic management and outcomes of patients presenting with Malignant breast myoepithelioma.