Oncology Research and Treatment

Wang G. · Guan S. · Yang X. · Sun S. · Huang B. · Li X.

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Article / Publication Details Abstract

Objective The aim of this study was to investigate the impact of valproic acid(VPA) on survival and prognosis of patients with glioma who underwent postoperative radiotherapy. Methods We obtained the case data with brain glioma who underwent postoperative radiotherapy from 2012 January to 2019 December. This cohort was heterogeneous. We conducted single factor analysis and multiple factors analysis of the basic features, pathological classification, therapies of all 185 patients using Kaplan-Meier survival curve, log-rank survival significance test and Cox-regression analysis model. Results By the end of the last follow-up, 94 patients had died and 96 had recurred in all 185 cases.The median follow-up time of this study was 47 months.The median overall survival (OS) and progression-free survival (PFS) times were 34 and 27 months, respectively. The 1-, 3- and 5-year OS rates were 86.49%, 48.11%, and 14.60%, respectively. The 1-, 3- and 5-year progression-free survival rates were 80.00%, 43.78%, and 12.97%, respectively. Univariate analysis revealed that age, pathological grade, and VPA administration were all associated with patients’ prognosis (p

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