Keywords: Anesthesia, General / methods, Dantrolene / therapeutic us, Diagnosis, Differential, Humans, Malignant Hyperthermia / diagnosis, Malignant Hyperthermia / etiology, Malignant Hyperthermia / physiopathology, Malignant Hyperthermia / therapy
AbstractA 42-year-old man with neck squamous cell carcinoma underwent awake fiberoptic intubation and tumor resection under general anesthesia. He developed malignant hyperthermia several hours into the surgical procedure. This case highlights malignant hyperthermia’s (MH) variable time course, pathognomonic signs, and the need for rapid diagnosis and treatment. Early recognition and treatment led to rapid resolution of MH. Ongoing discussion of MH is imperative because this disease is often difficult to diagnose early in its time course and may be fatal if not treated expeditiously.
Abbreviations: DS - Dantrolene sodium; DSIS - dantrolene sodium injectable suspension; GA - general anesthesia; MH - malignant hyperthermia; EtCO2 - end tidal carbon dioxide; RYR1 - Ryanodine Receptor gene
Key words: Anesthesia, General / methods; Dantrolene / therapeutic use; Diagnosis, Differential; Humans; Malignant Hyperthermia / diagnosis; Malignant Hyperthermia / etiology; Malignant Hyperthermia / physiopathology; Malignant Hyperthermia / therapy
Citation: Victor R, Kelly R, Cockrill R, Katrivesis K, Nelson C, Rajan G. A rare case of late onset malignant hyperthermia. Anaesth. pain intensive care. 2022;26(4):546-550; DOI: 10.35975/apic.v26i4.1963
Received: November 19, 2021; Reviewed: April 25, 2022; Accepted: July 12. 2022
Author BiographiesGovind Rajan
Govind Rajan, The University of California, Irvine Medical Center, 101 The City Dr S, Orange, CA 92868, United States
Robert Victor
Robert Victor, The University of California, Irvine Medical Center, 101 The City Dr S, Orange, CA 92868, United States
Richard Kelly
Richard Kelly, The University of California, Irvine Medical Center, 101 The City Dr S, Orange, CA 92868, United States
Ryan Cockrill
Ryan Cockrill, The University of California, Irvine Medical Center, 101 The City Dr S, Orange, CA 92868, United States
Karen Katrivesis
Karen Katrivesis, The University of California, Irvine Medical Center, 101 The City Dr S, Orange, CA 92868, United States
Corey Nelson
Corey Nelson, The University of California, Irvine Medical Center, 101 The City Dr S, Orange, CA 92868, United States
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