Spontaneous downbeat nystagmus and ocular flutter are rare clinical signs. Such findings are commonly related to cerebellar pathology, predominantly ischemia. In a significant percentage of patients, the cause may not be found. If these signs are associated with ataxia, cognitive decline, and seizure, anti-glutamic acid decarboxylase-associated neurological syndrome must be suspected. Background history of tumor has to be enquired. Treatment with immune modulation helps in partial recovery of such cases.

S.S. contributed in study concept and design, first draft, and literature review; A.V.R.T in study concept and design, first draft and literature review; M.G. in study concept and design, first draft, and literature review; S.N. in study concept and design, first draft and literature review, and critical review of manuscript for intellectual content; G.B.K. in study concept and design, interpreted the data, and critical review of manuscript for intellectual content; and S.A. in interpretation of the data and revision of the manuscript for intellectual content.

Article published online:
13 August 2022

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