Available online 12 August 2022

Alveolar bone loss is positively associated with the acquisition of COVID-19 disease.

Number of missing teeth is positively associated with severity of COVID-19 disease.

COVID-19 cases demonstrated fewer missing teeth and lack of smoking history vs controls.

Hospitalization among COVID-19 cases was positively associated with number of missing teeth.

Studies have shown that gingival crevices may be a significant route for SARS-CoV-2 entry. However, the role of oral health in the acquisition and severity of COVID-19 is not known.

Design: A retrospective analysis was performed using electronic health record data from a large urban academic medical center between 12/1/2019 and 8/24/2020. A total of 387 COVID-19 positive cases were identified and matched 1:1 by age, sex, and race to 387 controls without COVID-19 diagnoses. Demographics, number of missing teeth and alveolar crestal height were determined from radiographs and medical/dental charts. In a subgroup of 107 cases and controls, we also examined the rate of change in alveolar crestal height. A conditional logistic regression model was utilized to assess association between alveolar crestal height and missing teeth with COVID-19 status and with hospitalization status among COVID-19 cases.

Increased alveolar bone loss, OR=4.302 (2.510 – 7.376), fewer missing teeth, OR=0.897 (0.835 - 0.965) and lack of smoking history distinguished COVID-19 cases from controls. After adjusting for time between examinations, cases with COVID-19 had greater alveolar bone loss compared to controls (0.641+/- 0.613 mm vs 0.260 +/- 0.631 mm, p<0.01.) Among cases with COVID-19, increased number of missing teeth OR=2.1871 (1.146– 4.174) was significantly associated with hospitalization.

Alveolar bone loss and missing teeth are positively associated with the acquisition and severity of COVID-19 disease, respectively.

coronavirus disease 2019

severe acute respiratory syndrome virus 2

angiotensin-converting enzyme 2

transmembrane serine protease 2

alveolar crestal height

cemento-enamel junction

COVID-19

Coronavirus

Bone loss

Periodontal disease(s)/Periodontitis

Periodontal tissues/Periodontium

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