1 . Siegel RL, Miller KD, Fuchs HE, Jemal A. "Cancer Statistics, 2021" . CA Cancer J Clin. 2021; 71(1):7–33.

2 . Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al.. "Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries" . CA: A Cancer Journal for Clinicians. 2021; 71(3):209–49.

3 . Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. "Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries" . CA: A Cancer Journal for Clinicians. 2018; 68(6):394–424.

4 . Zhou J, Zheng R, Zhang S, Zeng H, Wang S, Chen R, et al.. "Colorectal cancer burden and trends: Comparison between China and major burden countries in the world" . Chin J Cancer Res. 2021; 33(1):1–10.

5 . Rawla P, Sunkara T, Barsouk A. "Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors" . Prz Gastroenterol. 2019; 14(2):89–103.

6 . Wang R, Wang M-J, Ping J. "Clinicopathological Features and Survival Outcomes of Colorectal Cancer in Young Versus Elderly: A Population-Based Cohort Study of SEER 9 Registries Data (1988-2011)" . Medicine. 2015; 94(35):e1402–e.

7 . Lee S-Y, Song WH, Oh SC, Min B-W, Lee SI. "Anatomical distribution and detection rate of colorectal neoplasms according to age in the colonoscopic screening of a Korean population" . Ann Surg Treat Res. 2018; 94(1):36–43.

8 . Vuik FER, Nieuwenburg SAV, Bardou M, Lansdorp-Vogelaar I, Dinis-Ribeiro M, Bento MJ, et al.. "Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years" . Gut. 2019; 68(10):1820.

9 . Siegel RL, Fedewa SA, Anderson WF, Miller KD, Ma J, Rosenberg PS, et al.. "Colorectal cancer incidence patterns in the United States, 1974–2013" . JNCI: Journal of the National Cancer Institute. 2017; 109(8).

10 . Siegel RL, Miller KD, Jemal A. "Cancer statistics, 2020" . CA Cancer J Clin. 2020; 70(1):7–30.

11 . Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al.. "Colorectal cancer statistics, 2020" . CA: A Cancer Journal for Clinicians.n/a(n/a).

12 . Wolf AMD, Fontham ETH, Church TR, Flowers CR, Guerra CE, LaMonte SJ, et al.. "Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society" . CA: A Cancer Journal for Clinicians. 2018; 68(4):250–81.

13 . Wong MCS, Huang J, Lok V, Wang J, Fung F, Ding H, et al.. "Differences in Incidence and Mortality Trends of Colorectal Cancer Worldwide Based on Sex, Age, and Anatomic Location" . Clinical Gastroenterology and Hepatology. 2021; 19(5):955–66. e61.

14. Ervik MJ CA, Ferlay J, Rahimi A, Antomi S, Dhivar Det al.. "CanReg5. Lyon, France: International Association of Cancer Registries" ; 2019. Computer Software for Cancer Registries

15 . "Cancer Annual Report [database on the Internet]" . Iraqi Ministry of Health/Iraqi Cancer Board. 2022 [cited 1/7/2021]. Available from: https://moh.gov.iq/upload/upfile/ar/106def1.pdf.

16 . Fritz A, Percy C, Jack A, Shanmugaratnam K, Sobin LH, Parkin DM, et al.. "International classification of diseases for oncology / editors, April Fritz" . [et al.]. 3rd ed ed. Geneva: World Health Organization; 2000.

17 . Clegg LX, Hankey BF, Tiwari R, Feuer EJ, Edwards BK. "Estimating average annual per cent change in trend analysis" . Stat Med. 2009; 28(29):3670–82.

18 . World Cancer Research Fund/American Institute for Cancer Research. "Diet, nutrition, physical activity and cancer: a global perspective" . Continues update project expert report2018.

19 . Almatroudi A. "The incidence rate of colorectal cancer in Saudi Arabia: an observational descriptive epidemiological analysis" . Int J Gen Med. 2020; 13:977.

20 . Sharkas GF, Arqoub KH, Khader YS, Tarawneh MR, Nimri OF, Al-Zaghal MJ, et al.. "Colorectal Cancer in Jordan: Survival Rate and Its Related Factors" . J Oncol. 2017;2017:3180762.

21 . Khanali J, Kolahi A-A. "National and Subnational Cancer Incidence for 22 Cancer Groups, 2000 to 2016: A Study Based on Cancer Registration Data of Iran" . Journal of Cancer Epidemiology. 2021 2021/07/13; 2021:6676666.

22 . Dabbagh R. "Current Trends of Substance Use in Iraq: Examining Data from the 2014 Iraqi National Household Survey of Alcohol and Drug Use" : University of California, Los Angeles; 2017.

23 . Hessami Arani S, Kerachian MA. "Rising rates of colorectal cancer among younger Iranians: is diet to blame?" Curr Oncol. 2017; 24(2):e131–e7.

24 . Siegel RL, Torre LA, Soerjomataram I, Hayes RB, Bray F, Weber TK, et al.. "Global patterns and trends in colorectal cancer incidence in young adults" . Gut. 2019; 68(12):2179.

25 . Campisi J. "Cancer and ageing: rival demons?" Nat Rev Cancer. 2003May; 3(5):339–49.

26 . Krtolica A, Parrinello S, Lockett S, Desprez P-Y, Campisi J. "Senescent fibroblasts promote epithelial cell growth and tumori-genesis: A link between cancer and aging" . Proceedings of the National Academy of Sciences. 2001; 98(21):12072.

27 . United Kingdom Cancer Research. "Bowel cancer incidence statistics" . 2013. Available from: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/bowel-cancer#heading-Six

28 . Aykan NF, Yalçın S, Turhal NS, Özdoğan M, Demir G, Özkan M, et al.. "Epidemiology of colorectal cancer in Turkey: A cross-sectional disease registry study (A Turkish Oncology Group trial)" . Turk J Gastroenterol. 2015Mar; 26(2):145–53.

29 . Kim S-E, Paik HY, Yoon H, Lee JE, Kim N, Sung M-K. "Sex- and gender-specific disparities in colorectal cancer risk" . World journal of gastroenterology. 2015; 21(17):5167–75.

30 . Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al.. "Colorectal cancer statistics, 2020" . CA: A Cancer Journal for Clinicians. 2020; 70(3):145–64.