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Article / Publication Details
Abstract
Purpose: To assess the prevalence of complete Retinal pigment epithelium (RPE) and outer retinal atrophy (cRORA) in patients with unilateral exudative Age-Related Macular Degeneration (AMD) of the fellow eye and establish if the presence of non-exudative macular neovascularization (NE-MNV) influences the prevalence of RPE and outer retinal atrophy in eyes with AMD.
Methods: Observational cross-sectional study of 68 patients with unilateral exudative AMD. Demographic and clinical data were collected and multimodal retinal imaging was performed in all patients. Two groups of patients were defined according to the presence (NE-MNV) or absence (No NE-MNV) of NE-MNV in the study eye. We compared the prevalence of tomographic cRORA and fundus autofluorescence (FAF) geographic atrophy (GA) and differences in cRORA greatest linear diameter (GLD) and GA area between groups.
Results: Globally, cRORA was present in 11 eyes (16.2%), FAF GA was present in 10 eyes (14.7%) and NE-MNV was present in 10 eyes (14.7%) of patients with unilateral exudative AMD of the fellow eye. The overall cRORA GLD was 1950.64 ± 1428.31 μm and the mean area of GA was 9.25 ± 7.50 mm2. Regarding comparisons between groups, cRORA was present in 9 eyes (15.5%) without NE-MNV and in 2 eyes (20%) with NE-MNV (p=0.66). Tomographic signs of atrophy were more frequent in eyes with NE-MNV (50% vs. 24.1% in eyes without NE-MNV; p=0.008). No significant differences were found in cRORA GLD (p=0.30) between groups. Eyes with NE-MNV and eyes without NE-MNV had a similar prevalence of FAF GA (2 eyes out of 10 and 8 eyes out of 58, respectively; p=0.64). Eyes with NE-MNV had a smaller mean area of GA (2.07±0.24 mm2 vs. 11.05±7.34 mm2; p=0.01).
Conclusion: In our study, the presence of NE-MNV was not associated with the prevalence of cRORA and/or FAF GA. Nonetheless, eyes with NE-MNV presented smaller areas of GA, which suggests that this type of neovascularization may prevent the progression of RPE and outer retinal atrophy. Longitudinal studies are required to confirm these preliminary results.
S. Karger AG, Basel
Article / Publication Details
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