Presented as a paper at the American Academy of Ophthalmology Meeting, November 2021, New Orleans, Louisiana

This article contains additional online-only material. The following should appear online-only: Table 2, Figure 1, Figure 6, and Appendix.

Biostatistical support was provided by research grants from Johnson & Johnson Vision, Santa Ana, California, the National Eye Institute (grant EY014801), National Institutes of Health, Bethesda, Maryland, and Research to Prevent Blindness, Inc., New York, New York.

The sponsors had no role in the design or conduct of this research.

Mr. Feuer has received grant support from Johnson & Johnson Vision. Dr. Ahmed is a consultant for Johnson & Johnson Vision. The other authors report no financial interest in the subject matter of this paper.

Tube shunt implantation and trabeculectomy with mitomycin C had similar rates of surgical failure after 5 years of follow-up in the PTVT Study.

Appendix. Participating Centers and Committees in the Primary Tube Versus Trabeculectomy (PTVT) Study

Clinical Centers:

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine (Miami, Florida): Principal Investigator: Steven Gedde, M.D.; Coinvestigators: Michael Banitt, M.D., Donald Budenz, M.D., M.P.H., Richard Lee, M.D., Ph.D., Paul Palmberg, M.D., Ph.D., Richard Parrish II, M.D., Luis Vazquez, M.D., Ph.D., Sarah Wellik, M.D., Mark Werner, M.D.

Cincinnati Eye Institute (Cincinnati, Ohio): Principal Investigator: Jeffrey Zink, M.D.; Coinvestigator: Anup Khatana, M.D.

Glaucoma Associates of Texas (Dallas, Texas): Principal Investigator: Davinder Grover, M.D., M.P.H.; Coinvestigator: Arvind Neelakantan, M.D.

Moorfields Eye Hospital (London, United Kingdom): Principal Investigator: Keith Barton, M.D.

New York Eye and Ear Infirmary (New York, New York): Principal Investigator: Joseph Panarelli, M.D.; Coinvestigator: Paul Sidoti, M.D., James Tsai, M.D., Kateki Vinod, M.D.

Queen Mary’s Hospital (Sidcup, United Kingdom): Principal Investigator: Saurabh Goyal, M.D.

St. Louis University (St. Louis, Missouri): Principal Investigator: John Lind, M.D.; Coinvestigator: Steven Shields, M.D.

St. Thomas Hospital (London, United Kingdom): Principal Investigator: Kin Sheng Lim, M.D.

University of California, Davis (Sacramento, California): Principal Investigator: James Brandt, M.D.

University of Florida (Gainesville, Florida): Principal Investigator: Mark Sherwood, M.D.

University of Oklahoma (Oklahoma City, Oklahoma): Principal Investigator: Mahmoud Khaimi, M.D.

University of Pennsylvania (Philadelphia, Pennsylvania): Principal Investigator: Prithvi Sankar, M.D.; Coinvestigators: Husam Ansari, M.D., Ph.D., Eydie Miller-Ellis, M.D.

University of Texas Houston (Houston, Texas): Principal Investigator: Robert Feldman, M.D.; Coinvestigators: Laura Baker, Nicholas Bell, M.D.

University of Toronto (Toronto, Canada): Principal Investigator: Iqbal Ahmed, M.D.; Coinvestigator: Donna Williams

University of Virginia (Charlottesville, Virginia): Principal Investigator: Bruce Prum, M.D.

Wilmer Eye Institute, Johns Hopkins University (Baltimore, Maryland): Principal Investigator: Pradeep Ramulu, M.D., Ph.D.; Coinvestigator: Henry Jampel, M.D.

Statistical Coordinating Center, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami (Miami, Florida): William Feuer, M.S., Luz Londono, Joyce Schiffman, M.S., Wei Shi, M.S., Yolanda Silva, Elizabeth Vanner, Ph.D.

Safety and Data Monitoring Committee: Philip Chen, M.D., William Feuer, M.S., Dale Heuer, M.D., Joyce Schiffman, M.S., Kuldev Singh, M.D., M.P.H., Martha Wright, M.D.

Steering Committee: Iqbal Ahmed, M.D., Keith Barton, M.D., James Brandt, M.D., Robert Feldman, M.D., Steven Gedde, M.D., Saurabh Goyal, M.D., Davinder Grover, M.D., M.P.H., Dale Heuer, M.D., Mahmoud Khaimi, M.D., John Lind, M.D., Kin Sheng Lim, M.D., Joseph Panarelli, M.D., Richard Parrish II, M.D., Bruce Prum, M.D., Pradeep Ramulu, M.D., Ph.D., Prithvi Sankar, M.D., Mark Sherwood, M.D., Jeffrey Zink, M.D.

Study Chairmen: Steven Gedde, M.D., Dale Heuer, M.D., Richard Parrish II, M.D.