Aberrant serine protease activities in atopic dermatitis

New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity.

J. Dermatol. Sci. 70: 3-11

The multifunctional role of filaggrin in allergic skin disease.

J. Allergy Clin. Immunol. 131: 280-291Palmer C.N. Irvine A.D. Terron-Kwiatkowski A. Zhao Y. Liao H. Lee S.P. et al.

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.

Nat. Genet. 38: 441-446Song C.W. Tabachnick J. McCarron Jr, D.J.

A trypsin-like protease in guinea pig skin.

Experientia. 25: 1063-1064

Experimental pruritus in the unaffected skin of patients with different itching dermatoses.

Acta Derm. Venereol. 50: 270-272Voegeli R. Rawlings A.V. Breternitz M. Doppler S. Schreier T. Fluhr J.W.

Increased stratum corneum serine protease activity in acute eczematous atopic skin.

Br. J. Dermatol. 161: 70-77Nomura H. Suganuma M. Takeichi T. Kono M. Isokane Y. Sunagawa K. et al.

Multifaceted analyses of epidermal serine protease activity in patients with atopic dermatitis.

Int J. Mol. Sci. 21Nomura H. Kawakami Y. Yasutomi Y. Morizane S.

Two atopic dermatitis patients in whom dupilumab improved aberrant epidermal protease activities.

J. Cutan. Immunol. Allergy. 2: 87-88Kraut H. Frey E. Werle E.

Der Nachweis eines Kreislaufhormon in der pankreasdruse.

Hoppe-Seyler Z. Physiol. Chem. 189: 97-106Yousef G.M. Diamandis E.P.

The new human tissue kallikrein gene family: structure, function, and association to disease.

Endocr. Rev. 22: 184-204Kalinska M. Meyer-Hoffert U. Kantyka T. Potempa J.

Kallikreins - The melting pot of activity and function.

Biochimie. 122: 270-282Caubet C. Jonca N. Brattsand M. Guerrin M. Bernard D. Schmidt R. et al.

Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7.

J. Invest Dermatol. 122: 1235-1244Nylander-Lundqvist E. Egelrud T.

Formation of active IL-1 beta from pro-IL-1 beta catalyzed by stratum corneum chymotryptic enzyme in vitro.

Acta Derm. Venereol. 77: 203-206Cork M.J. Robinson D.A. Vasilopoulos Y. Ferguson A. Moustafa M. MacGowan A. et al.

New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions.

J. Allergy Clin. Immunol. 118 (): 3-21Rippke F. Schreiner V. Doering T. Maibach H.I.

Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus aureus.

Am. J. Clin. Dermatol. 5: 217-223Komatsu N. Saijoh K. Kuk C. Liu A.C. Khan S. Shirasaki F. et al.

Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients.

Exp. Dermatol. 16: 513-519

Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation.

J. Biol. Chem. 274: 30033-30040Bonnart C. Deraison C. Lacroix M. Uchida Y. Besson C. Robin A. et al.

Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.

J. Clin. Invest. 120: 871-882Sakabe J. Yamamoto M. Hirakawa S. Motoyama A. Ohta I. Tatsuno K. et al.

Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes.

J. Biol. Chem. 288: 17179-17189Yamasaki K. Schauber J. Coda A. Lin H. Dorschner R.A. Schechter N.M. et al.

Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin.

FASEB J. 20: 2068-2080

Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions.

Biol. Chem. 389: 669-680Bin L. Kim B.E. Hall C.F. Leach S.M. Leung D.Y.

Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin.

J. Invest Dermatol. 131: 2213-2222Kamata Y. Yamamoto M. Kawakami F. Tsuboi R. Takeda A. Ishihara K. et al.

Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis.

J. Biol. Chem. 286: 8204-8212Morizane S. Yamasaki K. Kajita A. Ikeda K. Zhan M. Aoyama Y. et al.

TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis.

J. Allergy Clin. Immunol. 130 (): 259-261Morizane S. Yamasaki K. Kabigting F.D. Gallo R.L.

Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid.

J. Invest Dermatol. 130: 1297-1306Briot A. Deraison C. Lacroix M. Bonnart C. Robin A. Besson C. et al.

Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome.

J. Exp. Med. 206: 1135-1147Jang H. Matsuda A. Jung K. Karasawa K. Matsuda K. Oida K. et al.

Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model.

J. Invest Dermatol. Buhl T. Ikoma A. Kempkes C. Cevikbas F. Sulk M. Buddenkotte J. et al.

Protease-activated receptor-2 regulates neuro-epidermal communication in atopic dermatitis.

Front Immunol. 11: 1740Steinhoff M. Neisius U. Ikoma A. Fartasch M. Heyer G. Skov P.S. et al.

Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.

J. Neurosci. 23: 6176-6180Andoh T. Tsujii K. Kuraishi Y.

Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis.

Exp. Dermatol. 24: 978-980Oikonomopoulou K. Hansen K.K. Saifeddine M. Tea I. Blaber M. Blaber S.I. et al.

Proteinase-activated receptors, targets for kallikrein signaling.

J. Biol. Chem. 281: 32095-32112Zhu Y. Underwood J. Macmillan D. Shariff L. O’Shaughnessy R. Harper J.I. et al.

Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.

J. Allergy Clin. Immunol. 140 (): 1310-1322Furio L. de Veer S. Jaillet M. Briot A. Robin A. Deraison C. et al.

Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.

J. Exp. Med. 211: 499-513

Stratum corneum chymotryptic enzyme: a proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation.

Acta Derm. Venereol. 71: 471-474Hansson L. Stromqvist M. Backman A. Wallbrandt P. Carlstein A. Egelrud T.

Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.

J. Biol. Chem. 269: 19420-19426Igawa S. Kishibe M. Minami-Hori M. Honma M. Tsujimura H. Ishikawa J. et al.

Incomplete KLK7 secretion and upregulated lekti expression underlie hyperkeratotic stratum corneum in atopic dermatitis.

J. Invest Dermatol. 137: 449-456Hansson L. Backman A. Ny A. Edlund M. Ekholm E. Ekstrand Hammarstrom B. et al.

Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.

J. Invest Dermatol. 118: 444-449Guo C.J. Mack M.R. Oetjen L.K. Trier A.M. Council M.L. Pavel A.B. et al.

Kallikrein 7 promotes atopic dermatitis-associated itch independently of skin inflammation.

J. Invest Dermatol. 140 (): 1244-1252Stefansson K. Brattsand M. Roosterman D. Kempkes C. Bocheva G. Steinhoff M. et al.

Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases.

J. Invest Dermatol. 128: 18-25Vasilopoulos Y. Cork M.J. Murphy R. Williams H.C. Robinson D.A. Duff G.W. et al.

Genetic association between an AACC insertion in the 3′UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.

J. Invest Dermatol. 123: 62-66Vasilopoulos Y. Sharaf N. di Giovine F. Simon M. Cork M.J. Duff G.W. et al.

The 3′-UTR AACCins5874 in the stratum corneum chymotryptic enzyme gene (SCCE/KLK7), associated with atopic dermatitis; causes an increased mRNA expression without altering its stability.

J. Dermatol. Sci. 61: 131-133Hubiche T. Ged C. Benard A. Leaute-Labreze C. McElreavey K. de Verneuil H. et al.

Analysis of SPINK 5, KLK 7 and FLG genotypes in a French atopic dermatitis cohort.

Acta Derm. Venereol. 87: 499-505Eissa A. Amodeo V. Smith C.R. Diamandis E.P.

Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade.

J. Biol. Chem. 286: 687-706Williams M.R. Nakatsuji T. Sanford J.A. Vrbanac A.F. Gallo R.L.

Staphylococcus aureus induces increased serine protease activity in keratinocytes.

J. Invest Dermatol. 137: 377-384Yasuda T. Fukada T. Nishida K. Nakayama M. Matsuda M. Miura I. et al.

Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.

J. Clin. Invest. 126: 2064-2076Billi A.C. Ludwig J.E. Fritz Y. Rozic R. Swindell W.R. Tsoi L.C. et al.

KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.

J. Clin. Invest. 130: 3151-3157

Netherton syndrome: skin inflammation and allergy by loss of protease inhibition.

Cell Tissue Res. 351: 289-300Descargues P. Deraison C. Bonnart C. Kreft M. Kishibe M. Ishida-Yamamoto A. et al.

Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity.

Nat. Genet. 37: 56-65Fortugno P. Furio L. Teson M. Berretti M. El Hachem M. Zambruno G. et al.

The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitis.

Hum. Mol. Genet. 21: 4187-4200Ramesh K. Matta S.A. Chew F.T. Mok Y.K.

Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation.

Allergy. 75: 403-411Kobashi M. Morizane S. Sugimoto S. Sugihara S. Iwatsuki K.

Expression of serine protease inhibitors in epidermal keratinocytes is increased by calcium but not 1,25-dihydroxyvitamin D3 or retinoic acid.

Br. J. Dermatol. 176: 1525-1532Sugihara S. Sugimoto S. Tachibana K. Kobashi M. Nomura H. Miyake T. et al.

TNF-alpha and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes.

J. Dermatol. Sci. 96: 26-32

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