Clinical Experience in the Diagnosis and Treatment of Adult Acute Necrotizing Encephalopathy

Wang M.-L.a· Liu R.b· Zhang L.-M.a· Zhao B.a· Jia R.a· Zhao Y.a· Xi Y.-L.a· Ma J.-X.a· Ma H.a

Author affiliations

aDepartment of Neurology, Binzhou Medical University Hospital, Binzhou, China
bDepartment of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China

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Article / Publication Details

First-Page Preview

Abstract of Research Article

Received: November 02, 2021
Accepted: May 06, 2022
Published online: June 27, 2022

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

Abstract

Purpose: We report two cases diagnosed as acute necrotizing encephalopathy (ANE) with acute onset and various clinical manifestations. Methods: The patients’ data were obtained from the medical records of the Binzhou Medical University Hospital in Binzhou, China. The clinical symptoms, laboratory examination, neuroimaging, treatment, and prognosis of the 2 patients were collected and analyzed. Results: We report 2 adult ANE patients with acute onset. The first symptom was fever, followed by symptoms and signs of damage to the central nervous system. The patients were infected with herpes simplex virus and influenza virus, respectively. The main manifestation on brain magnetic resonance imaging was a mixed-signal of a “three-layer structure” in the bilateral thalamus. The first patient died. Based on the experience of the diagnosis and treatment of the first patient, combined with a review of the literature, the second patient was immediately treated with glucocorticoid pulse therapy combined with gamma globulin injection. This patient’s condition was controlled, and the prognosis was good. Conclusions: This study describes the clinical symptoms, laboratory examination, neuroimaging evidence, and treatment experience of ANE in adults. We believe that the progress of the disease may be controlled, and the prognosis may be improved if glucocorticoid pulse therapy combined with gamma globulin injection is used as soon as possible.

© 2022 S. Karger AG, Basel

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First-Page Preview

Abstract of Research Article

Received: November 02, 2021
Accepted: May 06, 2022
Published online: June 27, 2022

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

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