Shi W.a· Zhang W.b· Wang J.a

Author affiliations

aDepartment of Anesthesiology, Jincheng People’s Hospital, Jincheng, China
bDepartment of Anesthesiology, Changzhi People’s Hospital, Changzhi, China

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Article / Publication Details

First-Page Preview

Received: January 07, 2022
Accepted: March 10, 2022
Published online: May 11, 2022

Number of Print Pages: 11
Number of Figures: 5
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

Abstract

Introduction: Isoflurane-associated perioperative neurocognitive disorders (PNDs) is a common complication that occurs commonly in elderly patients characterized by deterioration of hippocampus-dependent cognitive function. Mounting evidence has shown that hippocampal impairment and inflammatory processes are implicated in the pathogenesis of PNDs. Catalpol has been suggested to play a role in the modulation of neuroprotection and neurotransmission. Therefore, we surmised that catalpol may play a similar role during isoflurane-induced PNDs. Methods: In our current study, aged mice were exposed to isoflurane to develop a mouse model of PNDs and preconditioned with catalpol for 2 weeks before modeling. Three weeks after isoflurane exposure, behavioral, histological, biochemical, electrophysiological, and immunofluorescent assays were performed. Results: Our results showed that catalpol preadministration significantly alleviated cognitive impairment in the Morris water maze, novel object recognition, and Y-maze behavioral tests. Neuropathological analyses showed that catalpol preadministration reduced the loss of neurons and synapses; in line with this, it is revealed that hippocampal synaptic plasticity was restored. Mechanistically, catalpol preadministration suppressed the activation of microglia and decreased the expression of NLRP3 inflammasome. Conclusion: Our results indicate that catalpol preadministration could effectively alleviate cognitive impairment and neuropathological damage in isoflurane-exposed aged mice with its neuroprotective effects via modulation of the NLRP3 inflammatory pathway. Furthermore, the NLRP3 inflammatory pathway was revealed to be involved in these effects.

© 2022 S. Karger AG, Basel

References Dai JW, Hong LQ, Han MF, Lin L, Duan ZW. Effects of propofol and gas anesthesia on cognitive impairment in elderly patients after surgery. J Biol Regul Homeost Agents. 2020;34(2):629–33. Liang LQ, Jiao YQ, Guo SL. Effects of sevoflurane inhalation anesthesia on cognitive and immune function in elderly patients after abdominal operation. Eur Rev Med Pharmacol Sci. 2018;22(24):8932–8. Olotu C. Postoperative neurocognitive disorders. Curr Opin Anaesthesiol. 2020;33(1):101–8. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, et al. Perioperative neurocognitive disorder: state of the preclinical science. Anesthesiology. 2020;132(1):55–68. Belrose JC, Noppens RR. Anesthesiology and cognitive impairment: a narrative review of current clinical literature. BMC Anesthesiol. 2019;19(1):241. Shen Y, Zhang Y, Chen L, Du J, Bao H, Xing Y, et al. Chemokine CXCL13 acts via CXCR5-ERK signaling in hippocampus to induce perioperative neurocognitive disorders in surgically treated mice. J Neuroinflammation. 2020;17(1):335. Fu Q, Li J, Qiu L, Ruan J, Mao M, Li S, et al. Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice. Int Immunopharmacol. 2020;82:106317. Subramaniyan S, Terrando N. Neuroinflammation and perioperative neurocognitive disorders. Anesth Analg. 2019;128(4):781–8. Zuo Y, Yin L, Cheng X, Li J, Wu H, Liu X, et al. Elamipretide attenuates pyroptosis and perioperative neurocognitive disorders in aged mice. Front Cell Neurosci. 2020;14:251. Zhang W, Xiong BR, Zhang LQ, Huang X, Zhou WC, Zou Q, et al. Disruption of the GABAergic system contributes to the development of perioperative neurocognitive disorders after anesthesia and surgery in aged mice. CNS Neurosci Ther. 2020;26(9):913–24. Wang X, Chen L, Xu Y, Wang W, Wang Y, Zhang Z, et al. Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation. Eur J Pharmacol. 2021;892:173734. Block ML. Neuroinflammation: modulating mighty microglia. Nat Chem Biol. 2014;10(12):988–9. Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16(3):278–90. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK. Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI Insight. 2017;2(7):e91229. Chen Q, Qi X, Zhang W, Zhang Y, Bi Y, Meng Q, et al. Catalpol inhibits macrophage polarization and prevents postmenopausal atherosclerosis through regulating estrogen receptor alpha. Front Pharmacol. 2021;12:655081. Chi X, Wang S, Baloch Z, Zhang H, Li X, Zhang Z, et al. Research progress on classical traditional Chinese medicine formula Lily Bulb and Rehmannia Decoction in the treatment of depression. Biomed Pharmacother. 2019;112:108616. Kim SH, Yook TH, Kim JU. Rehmanniae radix, an effective treatment for patients with various inflammatory and metabolic diseases: results from a review of Korean publications. J Pharmacopuncture. 2017;20(2):81–8. Si Y, Zhang Y, Han L, Chen L, Xu Y, Sun F, et al. Dexmedetomidine acts via the JAK2/STAT3 pathway to attenuate isoflurane-induced neurocognitive deficits in Senile mice. PLoS One. 2016;11(10):e0164763. Wang YL, Wu HR, Zhang SS, Xiao HL, Yu J, Ma YY, et al. Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation. Transl Psychiatry. 2021;11(1):353. Hu WH, Mak SH, Zheng ZY, Xia YJ, Xu ML, Duan R, et al. Shexiang Baoxin Pill, a traditional Chinese herbal formula, rescues the cognitive impairments in APP/PS1 transgenic mice. Front Pharmacol. 2020;11:1045. Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F. Pridopidine reverses phencyclidine-induced memory impairment. Front Pharmacol. 2018;9:338. Xie Z, Lu H, Yang S, Zeng Y, Li W, Wang L, et al. Salidroside attenuates cognitive dysfunction in senescence-accelerated mouse prone 8 (SAMP8) mice and modulates inflammation of the gut-brain axis. Front Pharmacol. 2020;11:568423. Roy A, Kundu M, Jana M, Mishra RK, Yung Y, Luan CH, et al. Identification and characterization of PPARα ligands in the hippocampus. Nat Chem Biol. 2016;12(12):1075–83. Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, et al. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008;4(1):42–50. Dinda B, Dinda M, Kulsi G, Chakraborty A, Dinda S. Therapeutic potentials of plant iridoids in Alzheimer’s and Parkinson’s diseases: a review. Eur J Med Chem. 2019;169:185–99. Wu X, Wang J, Song L, Guan Y, Cao C, Cui Y, et al. Catalpol weakens depressive-like behavior in mice with streptozotocin-induced hyperglycemia via PI3K/AKT/Nrf2/HO-1 signaling pathway. Neuroscience. 2021;473:102–18. Li DQ, Bao YM, Li Y, Wang CF, Liu Y, An LJ. Catalpol modulates the expressions of Bcl-2 and Bax and attenuates apoptosis in gerbils after ischemic injury. Brain Res. 2006;1115(1):179–85. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International study of post-operative cognitive dysfunction. Lancet. 1998;351(9106):857–61. Wen C, Xie T, Pan K, Deng Y, Zhao Z, Li N, et al. Acetate attenuates perioperative neurocognitive disorders in aged mice. Aging. 2020;12(4):3862–79. Fanselow MS, Dong HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron. 2010;65(1):7–19. Hara Y, Rapp PR, Morrison JH. Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age. 2012;34(5):1051–73. Liu Y, Zhang Y, Zheng X, Fang T, Yang X, Luo X, et al. Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice. J Neuroinflammation. 2018;15(1):112. Wang DS, Terrando N, Orser BA. Targeting microglia to mitigate perioperative neurocognitive disorders. Br J Anaesth. 2020;125(3):229–32. Saxena S, Kruys V, Vamecq J, Maze M. The role of microglia in perioperative neuroinflammation and neurocognitive disorders. Front Aging Neurosci. 2021;13:671499. Choi YH. Catalpol attenuates lipopolysaccharide-induced inflammatory responses in BV2 microglia through inhibiting the TLR4-mediated NF-κB pathway. Gen Physiol Biophys. 2019;38(2):111–22. Xia H, Wang D, Guo X, Wu K, Huang F, Feng Y. Catalpol protects against spinal cord injury in mice through regulating microRNA-142-mediated HMGB1/TLR4/NF-κB signaling pathway. Front Pharmacol. 2020;11:630222. Liu P, Gao Q, Guan L, Hu Y, Jiang J, Gao T, et al. Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice. Acta Biochim Biophys Sin. 2021;53(5):528–37. Article / Publication Details

First-Page Preview

Received: January 07, 2022
Accepted: March 10, 2022
Published online: May 11, 2022

Number of Print Pages: 11
Number of Figures: 5
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

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