Wang Y.a· Li R.a· Sun X.a· Liao J.a· Li J.b· Xia H.c· Peng L.a· Qiu W.a· Shu Y.a

Author affiliations

aDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
bDepartment of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
cDepartment of Research and Development, Hugobiotech Co., Ltd., Beijing, China

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Article / Publication Details

First-Page Preview

Received: August 19, 2021
Accepted: November 08, 2021
Published online: March 30, 2022

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

Abstract

Anti-IgLON5 encephalopathy is a new and rare autoimmune encephalitis with unclear pathophysiology. In this study, we reported an unusual case of anti-IgLON5 encephalopathy with concomitant herpes virus encephalitis. A 51-year-old man with HLA-DQB1*05:01 and HLA-DRB1*10:01, who suffered from an episode of acute encephalitis, mental disorders, and memory impairment was admitted to our hospital. Human alpha herpes virus 1, human gamma herpes virus 4 (Epstein-Barr virus), and IgLON5-IgG were detected in the cerebrospinal fluid, indicating anti-IgLON5 encephalopathy with concomitant herpes virus encephalitis of this patient. Brain magnetic resonance imaging revealed T2 hyperintensities in the left temporal lobe and enhancement in the hippocampus. A mild sleep disorder was also found by video polysomnography. The patient was then treated with antiviral drugs, intravenous immunoglobulins, methylprednisolone, and protein A immunoadsorption. After treatment, the patient’s clinical symptoms were partially improved. This is the first reported case of anti-IgLON5 encephalopathy with concomitant herpes virus encephalitis.

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First-Page Preview

Received: August 19, 2021
Accepted: November 08, 2021
Published online: March 30, 2022

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1021-7401 (Print)
eISSN: 1423-0216 (Online)

For additional information: https://www.karger.com/NIM

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