Yasuda K.a· Yamada S.a· Uenishi S.a,b· Ikeda N.a,c· Tamaki A.a,b· Ohoshi Y.a,b· Tsuji T.a· Takahashi S.a,d,e

Author affiliations

aDepartment of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan
bDepartment of Psychiatry, Hidaka Hospital, Gobo, Japan
cDepartment of Psychiatry, Wakayama Prefectural Mental Health Care Center, Aridagawa, Japan
dClinical Research and Education Center, Asakayama General Hospital, Sakai, Japan
eGraduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Habikino, Japan

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Article / Publication Details

First-Page Preview

Received: June 16, 2021
Accepted: November 18, 2021
Published online: January 14, 2022

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

Abstract

Introduction: The hippocampus is relevant to cognitive function in schizophrenia (SCZ) and mood disorder patients. Although not anatomically uniform, it is clearly divided into subfields. This study aimed to elucidate the relationship between hippocampal subfield volume and cognitive function in patients with SCZ, bipolar disorder (BP), and major depressive disorder (MDD). Methods: The study included 21 patients with SCZ, 22 with BP, and 21 with MDD and 25 healthy controls (HCs). Neurocognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia. We obtained hippocampal subfield volumes using FreeSurfer 6.0. We compared the volumes of the hippocampal subfield between the 4 groups and ascertained correlation between the cognitive composite score and hippocampal subfield volume in each group. Results: The SCZ group had significantly lower cognitive composite score than the BP, MDD, and HC groups. In the SCZ group, the left and right hippocampus-amygdala transition area and right subiculum and right presubiculum volumes were significantly reduced compared to those in the HC group. The left presubiculum volumes in the SCZ group were significantly reduced compared to those in the MDD group. Subfield volumes did not significantly differ between the BP, MDD, and HC groups. Interestingly, in the SCZ group, volumes of the right CA1, right molecular layer of the hippocampus, and right granule cell and molecular layer of the dentate gyrus were significantly correlated with the cognitive composite score. Conclusion: Patients with SCZ had poorer cognitive function, which is related to their hippocampal pathology, than those with mood disorders.

© 2022 S. Karger AG, Basel

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Article / Publication Details

First-Page Preview

Received: June 16, 2021
Accepted: November 18, 2021
Published online: January 14, 2022

Number of Print Pages: 11
Number of Figures: 3
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: https://www.karger.com/NPS

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