Lysine-specific histone demethylase 1 inhibition enhances robust fetal hemoglobin induction in human β0-thalassemia/hemoglobin E erythroid cells

Fucharoen S, Weatherall DJ. The hemoglobin E thalassemias. Cold Spring Harb Perspect Med 2012;2:a011734. DOI: https://doi.org/10.1101/cshperspect.a011734

Sripichai O, Fucharoen S. Fetal hemoglobin regulation in beta-thalassemia: heterogeneity, modifiers and therapeutic approaches. Expert Rev Hematol 2016;9:1129-37. DOI: https://doi.org/10.1080/17474086.2016.1255142

Musallam KM, Taher AT, Cappellini MD, Sankaran VG. Clinical experience with fetal hemoglobin induction therapy in patients with beta-thalassemia. Blood 2013;121:2199-212. DOI: https://doi.org/10.1182/blood-2012-10-408021

Shi L, Cui S, Engel JD, Tanabe O. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med 2013;19:291-4. DOI: https://doi.org/10.1038/nm.3101

Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004;119:941-53. DOI: https://doi.org/10.1016/j.cell.2004.12.012

Metzger E, Wissmann M, Yin N, et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 2005;437:436-9. DOI: https://doi.org/10.1038/nature04020

Cui S, Lim KC, Shi L, et al. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood 2015;126:386-96. DOI: https://doi.org/10.1182/blood-2015-02-626259

Rivers A, Vaitkus K, Ruiz MA, et al. RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases gamma-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model. Exp Hematol 2015;43:546-53. DOI: https://doi.org/10.1016/j.exphem.2015.04.005

Rivers A, Vaitkus K, Ibanez V, et al. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis). Haematologica 2016;101:688-97. DOI: https://doi.org/10.3324/haematol.2015.140749

Cui S, Kolodziej KE, Obara N, et al. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic beta-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol 2011;31:3298-311. DOI: https://doi.org/10.1128/MCB.05310-11

Yu L, Jearawiriyapaisarn N, Lee MP, et al. BAP1 regulation of the key adaptor protein NCoR1 is critical for gamma-globin gene repression. Genes Dev 2018;32:1537-49. DOI: https://doi.org/10.1101/gad.318436.118

Pevny L, Placzek M. SOX genes and neural progenitor identity. Curr Opin Neurobiol 2005;15:7-13. DOI: https://doi.org/10.1016/j.conb.2005.01.016

Yi Z, Cohen-Barak O, Hagiwara N, et al. Sox6 directly silences epsilon globin expression in definitive erythropoiesis. PLoS Genet 2006;2:14. DOI: https://doi.org/10.1371/journal.pgen.0020014

Xu J, Sankaran VG, Ni M, et al. Transcriptional silencing of gamma-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev 2010;24:783-98. DOI: https://doi.org/10.1101/gad.1897310

Li J, Lai Y, Luo J, et al. SOX6 downregulation induces γ-globin in human β-thalassemia major erythroid cells. Biomed Res Int 2017;2017:9496058. DOI: https://doi.org/10.1155/2017/9496058

Oh IH, Reddy EP. The myb gene family in cell growth, differentiation and apoptosis. Oncogene 1999;18:3017-33. DOI: https://doi.org/10.1038/sj.onc.1202839

Sankaran VG, Menne TF, Šćepanović D, et al. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci USA 2011;108:1519-24. DOI: https://doi.org/10.1073/pnas.1018384108

Jiang J, Best S, Menzel S, et al. cMYB is involved in the regulation of fetal hemoglobin production in adults, Blood 2006;108:1077-83. DOI: https://doi.org/10.1182/blood-2006-01-008912

留言 (0)

沒有登入
gif