Background

The skin of atopic dermatitis (AD) patients is characterised by abnormal stratum corneum (SC) lipid levels. Consequently, the lamellar matrices are disrupted and skin barrier function is diminished, increasing skin sensitivity to irritants and allergens.

Objective

To determine whether a cream containing ceramides, triglycerides and cholesterol in a multi-vesicular emulsion can reinforce the skin barrier, and protect against skin irritation.

Methods

A randomized observer-blind intrasubject-controlled study in 34 adults with dry, eczema-prone, skin was conducted. Each participant underwent 4 weeks treatment with the test cream on one forearm and lower leg and a reference emollient cream on the other. Skin properties were determined before and after treatment. Lipid structure was assessed by FTIR spectroscopy using a novel interface.

Results

Skin barrier integrity was greater at sites treated with the Test cream (effect size -161.9 area-under-the-TEWL-curve, 95% CI -205.5, -118.3), and skin sensitivity to sodium lauryl sulfate reduced (-0.5 points [97.57% CI -1.00, -0.25] visual redness and -15.34 g/m2/h [95% CI -20.28, -10.40] TEWL) compared to the reference. Sites treated with the test cream displayed enhanced lipid chain ordering, which was significantly associated with skin barrier integrity (r0.606). Compared to the reference, treatment with the Test cream increased hydration (8.61 capacitance units, 95% CI 6.61 to 10.60) and decreased signs of dryness.

Conclusion

The Test cream facilitates skin barrier restoration and protects the skin from dryness and irritation. Compared to a commonly prescribed emollient in the UK, the Test cream is highly suited to the management of dry, sensitive, skin.