Angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) drugs may modify risk associated with SARS-CoV-2. Therefore, we assessed whether baseline therapy with ACEI or ARB (ACEI/ARB) was associated with lower mortality, respiratory failure (non-invasive ventilation or intubation) and renal failure (new renal replacement therapy) in SARS-CoV-2-positive patients. This retrospective registry-based observational cohort study used data from a national database of Emergency Department (ED) patients tested for SARS-CoV-2. Symptomatic ED patients were accrued from January-October 2020, across 197 hospitals in the USA. Multivariable analysis using logistic regression evaluated endpoints among SARS-CoV-2-positive cases, focusing on ACEI/ARB and adjusting for covariates. Model performance was evaluated using the c statistic for discrimination, and Cox plotting for calibration. 13,859 (99.9%) patients had known mortality status, of whom 2,045 (14.8%) died. Respiratory failure occurred in 2,485/13,880 (17.9%) and renal failure in 548/13,813 (4.0%) patients with available data. ACEI/ARB status was associated with a 25% decrease in mortality odds (OR 0.75, 95% CI 0.59-0.94, p = .011, c = .82). ACEI/ARB was not significantly associated with respiratory failure (OR 0.89, 95% CI 0.78-1.06, p = .206) or renal failure (OR 0.75, 95% CI 0.55-1.04, p = .083). Adjusting for covariates, baseline ACEI/ARB was associated with 25% lower mortality in SARS-CoV-2-positive patients. The potential mechanism for ACEI/ARB mortality modification requires further exploration.

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